Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.

The invention disclosed herein concerns screening and early detection of a variety of disease conditions in seemingly healthy subjects, enabling early intervention and treatment.

The present disclosure provides systems and method for electric plasma synthesis of nitric oxide. In particular, the present disclosure provides a nitric oxide (NO) generation system configured to produce a controllable output of therapeutic NO gas at the point of care.

A method and apparatus deliver a variable flow of oxygen to a patient. The apparatus may include a flow control valve, a pressure sensor to detect a patient's breathing pressure and ambient pressure, an oxygen flow analyzer to measure oxygen flow to the patient, and a processor to analyze the breathing pressure values, ambient pressure value, and oxygen flow rate values and to determine when a patient is inhaling. When the processor determines the patient is inhaling, the processor calculates an optimal oxygen flow rate to deliver to a patient, which may depend on a pre-selected flow rate and an oxygen backlog, and the processor sends a signal to the flow control valve to deliver the optimal oxygen flow rate to the patient.

Systems and methods for generating and delivering nitric oxide are provided. In one aspect, a nitric oxide generator includes an inlet arranged to receive a gas including nitrogen and oxygen, an outlet, a pair of electrodes arranged downstream of the inlet and configured to generate nitric oxide from the gas, a pressure regulator configured to selectively adjust a pressure of the gas surrounding the electrodes, an accumulator in communication with the pressure regulator, a nitric oxide sensor arranged to measure a concentration of nitric oxide at the outlet, and a controller in communication with the pair of electrodes, the pressure regulator, and the nitric oxide sensor. The controller is configured to selectively instruct the pressure regulator to adjust the pressure of the gas surrounding the electrodes in response to the concentration of nitric oxide measured at the outlet by the nitric oxide sensor.

A side-stream respiration monitoring system that is configured to generate an alignment signal and assess information that is derived in part from the alignment signal to align in a time domain the respiration flow and composition information. The system includes an analyzer that is fluidly connected to a flow sensor that is disposed in a respiration flow path. The system includes a controller that is configured to initiate delivery of the alignment signal to the flow sensor during a portion of at least one breath cycle. The controller is configured to determine a flow rate of respiration flow and at least a portion of a composition of the respiration flow on a breath-by-breath basis and temporally associate the respiration flow value and the determined portion(s) of the composition of the respiration flow as a function of information associated with the alignment signal generated by the analyzer.

A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i].sup.T) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i].sup.T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

An additive gas delivery apparatus for delivery of additive gas to inspirational gas can be set to deliver the additive gas according to a dosing setting in normal therapy, and can be set to deliver according to a backup dosing setting in response disruption of signals representing data for controlling the delivery of additive gas according to the dosing setting in normal therapy. An additive gas delivery apparatus has an inlet for the additive gas and an integrated inlet for gas for oxygenating the patient that are connected to a backup line to mix the additive gas and gas for oxygenating the patient to a set concentration of additive gas in the gas mixture at an integrated backup outlet of the additive gas delivery apparatus.

A respiratory therapy system can have a flow generator adapted to provide gases to a patient. A gas passageway can be located in-line with the flow generator. The gas passageway can have a first portion adapted to receive a first gas and a second portion adapted to receive a second gas. The gas passageway can have a static mixer downstream of the first and second portions.