An injectate delivery device for expanding tissue is provided. The injectate delivery device comprises: at least one fluid delivery tube comprising a proximal end, a distal end and a lumen therebetween; at least one fluid delivery element in fluid communication with the at least one fluid delivery tube lumen; a radially expanding element comprising the at least one fluid delivery element; a supply of vacuum constructed and arranged to cause tissue to tend toward the at least one fluid delivery element; and at least one control constructed and arranged to perform a function. The at least one control can be constructed and arranged to expand the radially expandable element and activate the supply of vacuum. Systems and method of injectate delivery are also provided.

Catheters with deployable instruments (e.g., needles) can damage tissue if the instrument unintentionally deploys during use. Described herein are devices and methods for controlling the position of a deployable catheter instrument. In one embodiment, a catheter can include an instrument slidably disposed within an inner lumen of the catheter and coupled to at least one protrusion, as well as a retraction stop coupled to the catheter. The catheter can further include a biasing element coupled to the instrument that can urge the instrument proximally such that the at least one protrusion abuts against the retraction stop, as well as an advancing mechanism to selectively engage the instrument and urge it distally. In some embodiments, the biasing element can be omitted and a deployment stop can be included distal to the retraction stop. These configurations can prevent unintentional instrument deployment and provide greater positioning precision during instrument deployment.

A tubular body includes an elongated inner layer that demarcates a main lumen; a wire reinforcing layer that is formed by winding a reinforcing wire around the inner layer; a resinous elongated sub-tube that is arranged so as to extend along a longitudinal direction of the main lumen outside the wire reinforcing layer and demarcates a sub-lumen having a smaller diameter than the main lumen; a resinous outer layer that sheaths the wire reinforcing layer and the sub-tube; and a retaining wire. An operating wire is movably inserted through the sub-lumen, and has a tip connected to a distal portion of the tubular body. An operating part is operated to pull the operating wire to bend the distal portion of the tubular body. The retaining wire is sheathed by the outer layer, and winds together the sub-tube and the wire reinforcing layer. In a medical instrument (catheter), the retaining wire is in contact with a peripheral surface of the sub-tube on both an external diameter side and an outer surface of the wire reinforcing layer.

An injection device is described including a detection unit that includes an electrode that detects electrical characteristics of a biological tissue, a follow-up mechanism that follows motions of the biological tissue, and a puncture unit capable of puncturing the biological tissue. The injection device is configured to administer a predetermined substance to the biological tissue through a hollow portion defined in the puncture unit. A position of the puncture unit is specified based on a position of the electrode. The follow-up mechanism includes a spiral portion spirally extending around the puncture unit, and being stretchable and compressible along an extending direction of the puncture unit. Electrodes are disposed on an annular distal-end projected plane of the spiral portion, as seen from a distal end side of the puncture unit, along a circumferential direction of the puncture unit.

Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.

A biologics delivery device and method of use for promoting angiogenesis in occluded vessels and ischemic tissue of a patient are provided, wherein the biologics delivery device includes a catheter having a proximal end, a distal region having a distal end, and a side wall defining a catheter lumen; an expandable member disposed in the distal region, the expandable member configured to support a subintimal space in an occluded blood vessel of a patient, and to transition between a collapsed state and an expanded state; and a hollow needle having a penetration tip deployable from inside the catheter lumen to outside the catheter lumen, and into tissue surrounding the occluded blood vessel, wherein the expandable member in the expanded state allows the flow of oxygenated blood to the occluded blood vessel. Methods of using the inventive biologics delivery device also are provided to deposit the biologic from a subintimal space to tissue surrounding the occluded blood vessel.

Provided is an endoscope sheath including: a sheath body having an elongated rotating section and a stationary section, which are coupled to each other in a relatively rotatable manner about a longitudinal axis; a first passage along the axis; a second passage parallel to the first passage; an outlet through which a proximal end of an injection needle inserted in the second passage is pulled outside, the outlet being capable of changing a pullout position of the proximal end of the needle relative to the stationary section in the circumferential direction; and holders provided in the stationary section and separated by intervals in the circumferential direction, each holder securing an injector having the needle to the stationary section at a position where the needle protrudes from the distal end of the body and releasing the injector at a position where the needle is accommodated inside the body.

Embodiments of the present invention provide a device and a method for at least one disease by delivering an effective amount of energy and/or formulation to tissue on or near to a body lumen wall. The formulation can include at least one of a gas, a vapor, a liquid, a solution, an emulsion, a suspension of one or more ingredients, or a combination thereof. The amounts of the formulation and/or energy delivered can be effective to injure or damage tissue, nerves, and/or nerve endings to relieve disease symptoms.

The present invention describes a method for performing a prostate surgical treatment, said method comprising: arranging a catheter 1 inside of a urethra of a patient and anchored against the bladder neck of the patient subsequent to the filling of the balloon stopper unit 5 with a fluid when the balloon stopper unit 5 is arranged inside of the bladder of a patient;
said method also comprising injecting at least one anesthetic agent and adrenaline or injecting botulinum toxin (Botox) and/or penicillin to the prostate via the injection tube 9 and the hollow tip 10 at an intended position of the prostate.

Moreover, the present invention also refers to a kit comprising a catheter 1 according to the present invention and one or more syringe(s) 1000 containing adrenaline and at least one anesthetic agent and/or at least a syringe 1000 or vial containing botulinum toxin (Botox) and/or penicillin.

A medical device (10) and method for infusing a drug or like substance in vivo within tissue of an organ of a patient are provided. The device (10) includes an outer cannula (12) having a distal and proximal ends (14, 16) and a plurality of microcannulas (20, 22, 24) extending within a length of the outer cannula (12). Each of the microcannulas (20, 22, 24) having a distal end (28) and a proximal end (26) and being movable relative to the outer cannula (12) in a lengthwise direction between retracted and extended positions such that, in the retracted position, the distal ends (28) of the microcannulas (20, 22, 24) are located within the outer cannula (12) and, in the extended position, the distal ends (28) of the microcannulas (20, 22, 24) extend beyond the distal end (14) of the outer cannula (12) in a splayed configuration.