A method of removing tissue in a body lumen includes advancing a tissue-removing catheter over a guidewire in the body lumen to position a distal end of the catheter adjacent the tissue and a proximal end portion of the catheter outside of the body lumen. The catheter includes an elongate body, a tissue removing element mounted on a distal end portion of the elongate body, and an inner liner disposed within the elongate body. The inner liner defines a guidewire lumen in which the guidewire is disposed during the advancement of the catheter. The method further includes rotating the elongate body and tissue-removing element of the catheter to remove the tissue. Detecting wear of the inner liner caused by the elongate body contacting the inner liner during use.

In some examples, a catheter may include an elongate body and a push assembly. The elongate body may include an inner liner defining an entry port into a lumen defined by the elongate body, and an outer jacket. The push assembly may an anchor member positioned at a distal end of an elongate member. Distal to a proximal end of the elongate body, a first portion of the push assembly, comprising the anchor member, may be positioned between a portion of the inner liner and a portion of the outer jacket. The anchor member may extend only partially around an outer perimeter of the inner liner when the catheter is assembled. Proximal to the proximal end of the elongate body, a second portion of the push assembly, proximal to the first portion, may be positioned outside of the outer jacket and the inner liner.

An intraluminal sensing device includes a catheter or a guidewire with a flexible elongate member that is positioned within a body lumen of a patient. The device also includes a sensor disposed at a distal portion of the flexible elongate member. The sensor obtains medical data associated with the body lumen while the flexible elongate member is positioned within the body lumen. The sensor is an ultrasound transducer, a pressure sensor, a flow sensor, and/or a temperature sensor. The device further includes a radiopaque marker coupled to the flexible elongate member. The radiopaque marker is an ultraviolet (UV) radiation-cured product of a mixture that includes a radiopaque material, an electromagnetic-radiation-curable adhesive, and a photoinitiator. The solution of the mixture is applied directly to the flexible elongate member and UV radiation-cured to form the radiopaque marker. The radiopaque marker is a band extending around a perimeter of the flexible elongate member.

Methods of delivering cells and other therapeutic agents to organs and extravascular sites using an endoluminal delivery device are provided that allow for retention of the cells or agents at the delivery site at significantly improved levels as compared to needle delivery. Optimal delivery rates using the endoluminal delivery device are also provided. The methods allow for delivery of a variety of therapeutic agents to organs including heart, kidney and pancreas.

Disclosed herein are compositions of matter for inclusion in a medical device for visualization purposes. Such compositions may include a radiopaque metal, such as tungsten, within a functionalized hydrophobic polymer. Methods of making devices incorporating such elements are also disclosed.

A catheter (1) has a distal side and a proximal side and includes a tip part (10) and a main body part (20) disposed proximal to the tip part (10), the main body part (20) includes a first layer (21) and a second layer (22), the first layer (21) contains 60% by mass or more of an ethylene-tetrafluoroethylene copolymer, the second layer (22) is disposed inside of the first layer (21) in a radial direction of the catheter (1) and contains 60% by mass or more of a polyamide resin, and a cantilever bending load of the tip part (10) is smaller than a cantilever bending load of the main body part (20).

A coaxial multilumen annulus plane catheter, including an outer pigtail catheter enclosing one or two additional lumens, each housing either a slidable shaped wire or a second pigtail catheter shaped to fit into a wide range of annulus diameters and/or depths. In embodiments, the device may include a catheter delivery handle with thumb/finger-actuated sliders that extend or retract the shaped wires and are sized to enable side-to-side or radial motion, imparting a torque to the pre-shaped wires which translates the length of the wires to enable individually controlled rotation or sweep of each wire to accommodate different annulus diameters. The delivery handle includes hemostasis controls and flush ports. In other embodiments, a handle is obviated by direct lumen axial and rotational control at a proximal end.

Disclosed herein are vascular access systems and methods thereof. For example, a vascular access system includes a port configured for subdermal implantation and a single-use access device. The port can include a port hub and a catheter tube. The port hub can include an access funnel and a septum defining a pair of port-hub lumens. The catheter tube can include a septum defining a pair of catheter-tube lumens fluidly coupled to the pair of port-hub lumens. The access device can include a bifurcated hub and a pair of cannulas. The pair of cannulas defines a pair of cannula lumens coupled to a pair of access device-hub lumens of the bifurcated hub. The pair of cannulas can be configured to simultaneously insert into the access funnel and couple the pair of cannula lumens to the pair of catheter-tube lumens when the pair of cannulas is fully seated in the port hub.

The present invention relates to a system SY for determining a position of an RF transponder circuit RTC respective an ultrasound emitter unit UEU. The RF transponder circuit RTC emits RF signals that are modulated based on received ultrasound signals that are emitted or reflected by the ultrasound emitter unit UEU. The position of the RF transponder circuit RTC respective the ultrasound emitter unit UEU is determined based on a time difference ΔT1 between the emission of an ultrasound signal by the ultrasound emitter unit UEU and the detection by the RF detector unit RFD of a corresponding modulation in the RF signal emitted or reflected by the RF transponder circuit (RTC).

A system for creating separation between biological surfaces may comprise a hollow body configured for delivery of a fluid to a target location, a fluid supply in fluid-communication with the hollow body, a control element configured to control the delivery of a fluid through the hollow body, at least one first sensor configured to measure at least one parameter of the fluid flowing through the hollow body, at least one second sensor configured to measure at least one parameter of an environment of the hollow body, a feedback control module configured to receive information from one or more of the at least one first sensor or the at least one of the second sensor to control at least one operational function of the system.