A gastrointestinal device for treating obesity includes a three-dimensional porous structure configurable between a compressed pre-deployment configuration to facilitate delivery and an expanded post-deployment configuration. The porous structure includes a first opening at its proximal end and a larger second opening at its distal end. The porous structure also includes a sleeve coupled to its distal end. Optionally, the device further includes a suture at the proximal end of the wire mesh structure to facilitate retrieval and an anti-migration component positioned at the junction of the porous structure with the sleeve. The porous structure is deployed in a patient's stomach such that the anti-migration component sits proximal to the patient's pylorus and prevents migration of the entirety of the device into and through the pylorus. The sleeve extends through the pylorus, into the duodenum and ends in the duodenum or jejunum. Food enters the device from the first opening at the proximal end of the porous structure, passes through the porous structure and sleeve, and exits at the distal end of the sleeve. The device treats obesity by providing a relatively immovable volume occupying structure in the stomach and a bypass for food past the pylorus and proximal portion of the small intestine. Optionally, the device further acts to slow the passage of food through the digestive tract. Patients with the device experience satiety more quickly and have a prolonged sensation of satiety.

An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.

In some examples, a catheter includes an elongated body comprising proximal and distal portions. The distal portion of the elongated body comprises an inner liner that includes a proximal liner section and a distal liner section that include different materials, and an outer jacket positioned over the inner liner. The distal liner section has a first hardness and the proximal liner section has a second hardness, where the first hardness is less than the second hardness.

An introducer assembly includes a catheter having a proximal end, a distal end extending to a distal tip of the introducer assembly, and an outer catheter wall. The catheter includes a medical device holding portion proximate the distal end, a guide wire lumen extending between the proximal and distal ends, and a side opening extending through the outer wall to the guide wire lumen. The side opening and the guide wire lumen are simultaneously open and the guide wire lumen and side opening are able to receive a guide wire therethrough. The catheter is flexible at least in the location of the side opening. The catheter also includes a plurality of one stiffening mandrel lumens extending from the proximal end and a plurality of stiffening mandrels.

The present invention relates to a pose estimation method of an interventional medical device using a single-view X-ray image which is captured using a bendable interventional medical device equipped with a plurality of radiopaque markers and using an X-ray source. The pose estimation method includes an operation (a) of defining a circle assuming that the interventional medical device is bent at a constant curvature, an operation (b) of extracting a position value of the marker from an X-ray image obtained by the X-ray source projecting X-rays onto the markers, and an operation (c) of setting a projection plane and estimating a shape of the circle using a position value of the marker extracted from a projected image obtained by perspective-projecting the circle onto the projection plane and using the position value of the marker extracted from the X-ray image.

An implant comprises a wall that surrounds a lumen. A delivery tool comprises a catheter, a control assembly, and an ultrasound tool. The catheter is transluminally advanceable into a subject, and has a distal opening. The implant can be delivered via the catheter. The control assembly can advance at least a portion of the wall out of the distal opening, and can steer the catheter to place the portion against a site of a tissue of the subject, the site disposed distally from the portion and opposite the distal opening. The ultrasound tool can (i) position an ultrasound transceiver within the lumen and facing the portion, and (ii) facilitate imaging of the site by transmitting ultrasound energy through the portion. An anchor driver can anchor the implant to the tissue by driving an anchor through the portion and into the site. Other embodiments are also described.

A mixed reality (MR) visualization system includes an MR device comprising a holographic display configured to display a holographic image to an operator, a hand-held ultrasound imaging device configured to obtain a real-time ultrasound image of a subject's anatomy, and a computing device communicatively coupled to the MR device and the hand-held ultrasound imaging device. The computing device includes a non-volatile memory and a processor. The computing device is configured to receive the real-time ultrasound image, determine a real-time 3D position and orientation of the hand-held ultrasound imaging device, generate a modified real-time ultrasound image by modifying the real-time ultrasound image to correspond to the real-time 3D position and orientation of the hand-held ultrasound imaging device, and transmit the modified real-time ultrasound image to the MR device for display as the holographic image positioned at a predetermined location relative to the hand-held ultrasound imaging device.

A catheter including an inner liner, a reinforcement layer disposed about the inner liner and having a distal edge separated a predetermined axial distance in a proximal direction from the distal end of the inner liner. The reinforcement layer having a discrete annealed section with an altered crystalline structure having modified (e.g., increased) stiffness relative to non-annealed sections of the reinforcement layer. A marker band is positioned over or adjacent to the distal edge of the reinforcement layer. An outer jacket is disposed about an interim assembled structure including the inner liner, the reinforcement layer, and the marker band to form an assembled structure. During manufacture, heat is applied to reflow together individual components of the assembled structure producing an integral composite catheter shaft.

An example catheter caliper according to the present disclosure includes a tube having a plurality of markers at predetermined intervals and a wire extending from the tube, wherein the catheter caliper is configured to be received into the vasculature of a patient. Other example catheter calipers and example methods of using the catheter caliper is also disclosed.

The invention relates to a system for assisting in navigating a medical device (1) in a region of a patient body, such as a cardiac chamber. The system comprises a unit (5) for providing a three-dimensional model of the region and an ultrasound probe (2) for acquiring image signals of the region of the patient body. At least one an ultrasound sensor (6) is attached to the medical device (1) for sensing ultrasound signals emitted by the 5 ultrasound probe (2) and a tracking unit (7) determines a relative position of the at last one ultrasound sensor (6) with respect to the live images and/or the ultrasound probe (2) on the basis of the sensed ultrasound signals. Further, a mapping unit (8) maps the determined relative position of the at least one ultrasound sensor (6) onto the model to generate a visualization of region of the patient body.