The present embodiments provide systems and methods suitable for delivering an agent including a plurality of particles to a target site. In example embodiments, a system suitable for delivering an agent to a target site includes a catheter having a first wall defining a lumen sized for delivery of the agent to the target site. The catheter has a distal end terminating with a primary opening of the lumen, an opposing proximal end, and a longitudinal axis extending between the distal end and the proximal end. At least one secondary opening is formed at the distal end, wherein the secondary opening is configured to allow fluid to flow through the secondary opening to create a steady flow of fluid at an angle with respect to the longitudinal axis and prevent the plurality of particles from flowing through the secondary opening.

The subject guide catheter extension system with a micro-catheter delivery catheter includes an outer sheath, an inner member extending within the sheath, and a mechanism for engagement/disengagement of the inner member to/from the sheath. Several mechanisms of engagement/disengagement between the inner and outer members are provided including a friction mechanism, threaded mechanism, pull away sheath, and engagement/disengagement mechanism for pusher's handles. The sheath and the inner member are modified for different engagement/disengagement mechanisms operation. A micro-catheter delivery system provides for an improved atraumatic crossability to the treatment site in an expedited and simplified fashion. During a procedure, a guidewire along with a guide catheter are advanced to the vicinity of the treatment site within a blood vessel. Subsequent thereto, the subject guide catheter extension system is manipulated to advance the micro-catheter along the guidewire inside the guide catheter towards and beyond the site of interest. Once the micro-catheter is in place, the outer sheath slides along the micro-catheter until reaching the lesion, and then the inner member is removed from the sheath, and the sheath then is ready for passing the treatment catheter (stent/balloon) towards the lesion to be treated.

Devices, systems, and methods for aiding insertion of a surgical implant by providing a threaded guide tube configured to engage a threaded surgical instrument such that an end-effector of a robot may provide force to drive the surgical implant into a patient. In addition, devices, systems, and methods relating to a dilator system for use with a robotic system that allows independent and separate control of tools within the dilator system.

The designs and methods disclosed herein are for a clot retrieval catheter that can have a proximal elongate body with a large bore lumen and a distal tip expandable to a diameter larger than the outer sheath through which it is delivered. The distal tip can have a flexible metallic support frame to provide radial scaffolding and the ability for further flexible expansion when ingesting a clot. The support frame can be designed so that the expanding movement is focused in a portion of the circumference though a plurality of deformable cells that can collapse to be almost flat and parallel to the longitudinal axis for deliverability, but expand to a very steep angle for good resistance to collapse under aspiration. The designs can be sufficiently flexible to navigate tortuous anatomy but recover to maintain the inner diameter of the lumen when displaced in a vessel.

An introducer assembly includes a plurality of selectable side holes through which a fluid can be delivered. In some examples, an introducer assembly includes an outer elongated body defining a plurality of outer body side holes and an inner elongated body defining a plurality of inner body side holes. The inner elongated body is configured to rotate relative to the outer elongated body between a first rotational orientation in which a first subset of outer body side holes aligns with a first subset of inner body side holes and the inner elongated body blocks fluid flow out of the outer elongated body through a second subset of outer body side holes, and a second rotational orientation in which the second subset of outer body side holes aligns with a second subset of inner body side holes and inner elongated body blocks fluid the first subset of outer body side holes.

Arterial access sheaths for delivering a treatment, such as a transcatheter aortic valve treatment, having markers configured to illustrate orientation of the distal end region of the sheath. Related systems, devices, and methods are provided.

A method, system and apparatus for performing an interventional procedure, the method includes retrograde advancement of a first guidewire into the femoral artery and advancing a sheath system over the guidewire and inserting the distal end of a sheath system through an incision and into the femoral artery of the patient. The sheath system comprises a retrograde sheath having an antegrade sheath removably connected thereto, wherein the retrograde sheath comprises a lumen extending between a retrograde sheath distal end and a retrograde sheath proximal end and wherein the antegrade sheath comprises a lumen extending between an antegrade sheath distal end and an antegrade sheath proximal end, the access sheath system further comprising separable section connecting the retrograde sheath to the antegrade sheath. The method further includes separating the retrograde sheath from the antegrade sheath via the tear away section, and performing an antegrade interventional procedure.

A system for delivering a fluid to a Eustachian tube (ET) of a patient includes a guide member and a tubular member. The guide member includes a shaft having a proximal portion, a distal portion, and a bend at the distal portion. The bend is configured to provide access to an opening in the ET. The system further includes a tubular member comprising a proximal end, a distal end, and a lumen extending therebetween. The tubular member is sized to fit within the ET. One or both of the tubular member and the guide member comprises a first stop member configured to engage the other of the tubular member or the guide member. The first stop member is configured to restrict a distal advancement of the tubular member relative to the guide member.

A slave-end apparatus for an interventional robot includes: a body, and a front clamper, a first drive mechanism, a second drive mechanism and a third drive mechanism that are mounted on the body; wherein in a case that the first guide wire runs into the second catheter, the second catheter runs into the first catheter, and the first guide wire, the second catheter and the first catheter are move along on the body to a desired position, the front clamper and the second drive mechanism take over to clamp the first catheter and the second catheter, the third catheter is caused to run into the second catheter and the second guide wire is caused to run into the third catheter, and the third catheter and the second guide wire are respectively clamped by the second drive mechanism and the third drive mechanism and move on the body.

A medical device system may include a sheath, a pusher wire, and a locking element. The sheath may have a first outer diameter adjacent to the proximal end and an enlarged outer diameter region having a second outer diameter greater than the first adjacent to the intermediate region. The pusher wire may be slidably disposed within a lumen of the sheath. The locking element may have a lumen extending therethrough. The locking element may have a first inner diameter adjacent to the distal end and a second inner diameter smaller than the first adjacent to the intermediate region. The locking element may configured to freely slide over a region of the sheath having the first diameter. When the locking element is disposed over the enlarged outer diameter region of the sheath having the second outer diameter, the locking element may be configured to depress the sheath radially inwards.