A guide wire includes a core shaft having an elongated outer shape, a first coil body disposed to surround a distal end portion of the core shaft, a second coil body disposed radially outside from the first coil body, and a distal tip fixing a distal end of the core shaft and a distal end of the first coil body. In the longitudinal direction of the core shaft, a distal end of the second coil body is positioned between the distal end of the first coil body and a proximal end of the first coil body, a proximal end of the second coil body is positioned on the more proximal end side than the proximal end of the first coil body, and bending stiffness of the first coil body is smaller than bending stiffness of the second coil body.

Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

There is described a pressure guidewire. It comprises a sensor housing and a sensor assembly embedded in the sensor housing and comprising a pressure sensor. There is a band to support the pressure sensor assembly, the band being embedded inside the sensor housing and fixed to the pressure sensor assembly for holding the pressure sensor inside the sensor housing.

One aspect provides a medical guidewire including a core wire extending from a proximal tip of a proximal end section to a distal tip of a distal end section. A polymer layer covers a perimeter surface of at least a portion of the distal end section, the polymer layer covering the distal tip and extending proximally to a proximal end portion defining a proximal edge. A strengthening feature is disposed about a perimeter surface of at least the core wire at the proximal end portion of the polymer layer, the strengthening feature beginning at a location proximally spaced from the proximal edge of the polymer layer and extending distally at least until the proximal edge of the polymer layer, the strengthening feature to prevent damage to the proximal end portion of the polymer layer.

A composite wire, such as a guide wire, may include a principal section with a relatively large outer diameter, as well as one or more reduced sections with smaller outer diameters. The relatively small outer diameter of each reduced section may be defined by an inner element of the composite wire, while the relatively large outer diameter of the principal section may be defined by one or more outer elements that reside on, and may surround, the inner element. The inner and outer elements may be formed from materials that impart the composite wire with one or more desired characteristics, such as a stiffness, hardness and flexibility. In specific embodiments, the inner element may comprise a standard, small diameter guide wire, while the outer element comprises a polymer.

A guidewire for backloading and inserting a percutaneous pump affixed to a cannula includes a proximal section made of a first material, with a first diameter, a rounded proximal end, and a distal end. The guidewire also includes a distal section made of a second material, with a second diameter which is greater than the first diameter, a distal end, and a proximal end abutting the distal end of the proximal section. The first material of the proximal section is selected to be softer than a material of the percutaneous pump to reduce damage to the pump during backloading. The distal section of the guidewire is configured to be stiffer than the proximal section to insert the percutaneous pump in a desired location without damaging the guidewire.

A catheter assembly for use in a percutaneous heart pump is provided. The catheter assembly may include a GWG that includes a hypotube and a sleeve section coupled to a distal end of the hypotube. The sleeve section is configured to extend across a distal septum of the percutaneous heart pump when the GWG is inserted into the percutaneous heart pump, and facilitate reducing deformation of the distal septum while the sleeve section extends across the distal septum.

Provided is a medical guidewire that ensures adhesion of a coating layer and exhibits excellent smoothness. A medical guidewire including includes a wire body that is flexible and long, an intermediate layer that has at least one layer and covers a surface of the wire body, and an outermost layer that covers a surface of the intermediate layer. The intermediate layer is colored by including a pigment, and a concentration of the pigment is 50 wt % or more and 90 wt % or less with respect to the intermediate layer as a whole.

Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing an intravascular device having a distal portion with a lumen extending therein; inserting the device into the vascular lumen; positioning the distal portion in the vascular wall; and directing the distal portion within the vascular wall.

Shapeable guide wire devices and methods for their manufacture. Guide wire devices include an elongate shaft member having a shapeable distal end section that is formed from a linear pseudoelastic nickel-titanium (Ni—Ti) alloy that has linear pseudoelastic behavior without a phase transformation or onset of stress-induced martensite. Linear pseudoelastic Ni—Ti alloy, which is distinct from non-linear pseudoelastic (i.e., superelastic) Ni—Ti alloy, is highly durable, corrosion resistant, and has high stiffness. The shapeable distal end section is shapeable by a user to facilitate guiding the guide wire through tortuous anatomy. In addition, linear pseudoelastic Ni—Ti alloy is more durable tip material than other shapeable tip materials such as stainless steel.