Medical devices and systems for treating a stricture along the biliary and/or pancreatic tract are disclosed. An example medical device may include a guidewire for use along the biliary and/or pancreatic tract. The guidewire may include an elongate core member having a proximal end region and a distal end region. A coil member may be disposed along the distal end region. An actuation member may be coupled to the coil member. The actuation member may be configured to shift the coil member between a first configuration and a compressed configuration. The coil member may be configured to be advanced across a biliary and/or pancreatic stricture when in the compressed configuration. A sleeve may be disposed over the coil member.

A guide wire includes an elongated wire body having flexibility; a distal member that covers a distal portion of the wire body and is configured to have a resin material; and a hydrophilic lubricant layer that is formed so as to cover a proximal end of the distal member and is configured to have a hydrophilic material. In addition, the hydrophilic lubricant layer has a tapered shape whose outer diameter gradually decreases toward a proximal side. In addition, the maximum outer diameter of the hydrophilic lubricant layer is smaller than the maximum outer diameter of the distal member. In addition, a proximal portion of the distal member has a tapered shape whose outer diameter gradually decreases toward the proximal side, and a distal end of the hydrophilic lubricant layer is positioned at the tapered portion of the distal member.

A dilation apparatus comprises an elongate member and a dilation assembly that is slidable along the elongate member. The dilation assembly comprises a platform and an inflatable dilator. The platform and the elongate member cooperate to absorb inflation forces from the dilator directed toward the longitudinal axis of the elongate member, such that the dilation forces are exerted against tissue asymmetrically relative to the longitudinal axis of the elongate member. The dilation apparatus may be used to dilate the ethmoid infundibulum in a human patient. Various devices may be used to maintain the dilated state of an ethmoid infundibulum, including a wedge, a mesh, and a tether. An illuminator may be configured to reach around an uncinate process, retract the uncinate process, and then illuminate the ethmoid infundibulum to provide improved visualization of the ethmoid infundibulum.

A guidewire system may include a guidewire having a relatively stiff proximal section and a relatively flexible distal section joined by a transition region, and a TAVI device slidably disposed on the guidewire. The guidewire may include an expandable element disposed about the transition region. The expandable element may be configured to expand from a collapsed configuration to an expanded configuration. The guidewire may include an expandable element disposed at the distal end. The distal section may be pre-configured to form more than one distal loop. A method of protecting an apex of a left ventricle during a TAVI procedure may include inserting a guidewire into the left ventricle, positioning a transition region adjacent the apex, expanding an expandable element such that the expandable element spans the apex, advancing a TAVI device distally over the guidewire to an aortic valve, and performing a TAVI procedure at the aortic valve.

A guide wire includes an elongated core wire possessing a distal portion at which is located a reshaping portion that is configured to be reshaped. The reshaping portion includes a first material portion made of a first material and a second material portion which is made of a second material different than the first material. The first material portion is joined to the second material portion at a joint surface which extends in the longitudinal direction of the core wire.

A guidewire assembly having selectively adjustable stiffness and tip curvature includes a hollow guidewire having a distal portion terminating at a distal tip, a curvature-modifying element anchored to the distal tip, and a stiffness-modifying element displaceable within the hollow guidewire towards and away from the distal tip so as to vary a stiffness of the distal portion. The stiffness-modifying element and the curvature-modifying element are frictionally linked such that movement of the stiffness-modifying element from a current position over a first range of motion causes corresponding displacement of the curvature-modifying element, thereby modifying a state of curvature of at least part of the distal portion of the guidewire. Movement of the stiffness-modifying element beyond the first range of motion displaces the stiffness-modifying element relative to the curvature-modifying element.

A catheter comprises a hollow sheath, a guidewire extendable through the hollow sheath, where the guidewire comprises a controllably bendable tip portion, a hollow tubular intermediate portion connected to the tip portion, an electrical connection portion connected to the hollow tubular portion, at least a first wire extending through the hollow tubular portion and connected at a first end thereof to a first circumferential conductor and at a second end thereof to a surface of the tip end, and a power supply connector, therein the electrical connection portion is received in the power supply connector and a first terminal in the power supply connector contacts the first circumferential conductor.

An articulated medical device having a hollow core, capable of large degrees of maneuverability through small spaces of a patient to reach a target with minimal invasiveness, and once the medical device has reached the target, allowing a medical tool to be guided through the hollow chamber for facilitating medical procedures, including endoscopes, cameras, and catheters, at the target.

A double guide wire includes two guidewires deployed concentrically, one within the other. Each guidewire is formed as an elongated flexible shaft having a distal portion including a deflectable helical coil terminating at a distal tip. The first guidewire is implemented as a hollow guidewire having a central lumen extending along its length, while the second guidewire is configured as a smaller gauge guidewire deployed within the central lumen of the first guidewire. An adjuster mechanism allows the inner guidewire to be advanced and retracted relative to the outer guidewire, transforming the guidewire between: a first state in which the distal tip of the second guidewire is adjacent to the distal tip of the first guidewire; and a second state in which at least part of the distal portion of the inner guidewire is advanced beyond the distal tip of the first guidewire.

Guidewires and thin-film catheter-sheaths, fabricated using vacuum deposition techniques, which are monolayer or plural-layer members having ultra-thin wall thicknesses to provide very-low profile delivery assemblies for introduction and delivery of endoluminal devices.