A guide wire of the present disclosure includes a core shaft having a distal end portion decreasing in diameter, a coil body wound to cover the distal end portion, and a distal end fixing portion fixing the core shaft and the coil body to each other. The distal end portion includes a small diameter portion, a large diameter portion, and a tapered portion between the small diameter portion and the large diameter portion. The core shaft and the coil body are fixed at a portion excluding the tapered portion. A first bending rigidity FR1 of the large diameter portion, a second bending rigidity FR2 of the small diameter portion, and a length L of the tapered portion satisfy the following expressions (1) and (2). In the following expressions (1) and (2), the unit of L is mm (millimeter).

A guidewire for vascular access has an elastically articulatable tip configured to minimize risk of vessel wall damage during initial insertion of the guidewire into the vasculature of a patient. The guidewire may have a local flexible portion in a tip segment of the guidewire and/or a core thereof.

A drug eluting guide wire comprises a body aperture having low friction characteristics. The guide wire includes an effective leading end segment that is formed along its outer surface with a rapid action body aperture drug eluting agent serving as a vasilodating substance. The low friction characteristics are achieved by the leading end segment of the wire being covered with a low friction lubricating substance such as hydrogel that is loaded with a drug eluting substance in the form of isoprenaline in constituting the segment. Isoprenaline serves a constricted body aperture rapid action relaxing function in amongst others, or at least the case of the guide wire, is used to access a kidney along a ureter in response to temporarily paralyzing the smooth muscles of the ureteric wall resulting in widening of the lumen of the ureter.

An improved guidewire may include an elongate shaft including a distal section and a proximal section extending proximally from the distal section. The elongate shaft includes a coiled portion disposed within the distal section. The coiled portion is curved in a first direction in a first plane. The elongate shaft includes a reverse curve portion curved in a second direction opposite the first direction. The reverse curve portion is disposed proximal of the coiled portion. A kit for forming the improved guidewire may include a guidewire having a coiled portion and a forming tool configured to form a reverse curve portion in the guidewire proximal of the coiled portion.

A guidewire having a first end and a second end, and comprising two or more guidewire modules. Each guidewire module has a first end and a second end. Each guidewire module is configured to be attachable to a second guidewire module by at least one of: attaching the first end of the guidewire module with the second end of the second guidewire module, and attaching the second end of the guidewire module with the first end of the second guidewire module.

A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

A steerable transseptal punch system and method of using the steerable transseptal punch system to access the left atrium.

Guidewires and methods of use of guidewires having improved atraumatic tips that can distribute force to lessen trauma as well as anchor the guidewire to facilitate improved catheter exchange.

A modular guidewire system includes at least one guidewire module having a solid polygonal shaped prism extending from a body of the guidewire module at a first end and a recess having a polygonal prism shape at a second end. The modular guidewire system also includes at least one guidewire tip module having a tip at a first end and connecting end at a second end, the connecting end including a solid polygonal shaped prism extending from a body of the guidewire tip module or a recess having a polygonal prism shape. A first guidewire module is attachable to a first guidewire tip module by inserting the solid polygonal shaped prism of the guidewire module into the polygonal prism shaped recess of the guidewire tip module, or inserting the solid polygonal shaped prism of the guidewire tip module into the polygonal prism shaped recess of the guidewire module.

Intravascular devices, systems and methods of fabricating the same are provided. In one embodiment, an intravascular system includes an intravascular guidewire that includes a flexible elongate member having a proximal portion and a distal portion, at least one electronic component secured to the distal portion of the flexible elongate member, and a locking section integral with a metal core of the flexible elongate member at the proximal portion of the flexible elongate member. The metal core has a first diameter. The locking section includes a first subsection and a second subsection. The first subsection has a second of diameter smaller than the first diameter and the second subsection transitions between the first diameter and the second diameter.