The invention provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device includes an elongate shaft having a distal region and a coil disposed along the distal region. The coil is formed from a winding member having a first filar region and a second filar region. The winding member has a first cross-sectional diameter along the first filar region, a second cross-sectional diameter different from the first cross-sectional diameter along the second filar region, a first centroid at a first position along the first filar region and a second centroid at a second position along the second filar region. The first centroid and the second centroid are axially-aligned.

A biopsy device, comprising a flexible coaxial structure, comprising an obturator within a sheath, the obturator being adapted to be displaced with respect to the sheath along the coaxial axis by a force applied at a proximal end; a disruptor, at a distal end of the obturator, adapted to disrupt a tissue surface to free cells therefrom, having a first position covered within the sheath and a second position freely extending beyond the sheath; an element, having a fixed position on the obturator, and a close clearance with respect to an inner surface of the sheath, such that a retraction of the obturator within the sheath causes an associated change in pressure in a space between the obturator distal to the element and the sheath, to thereby draw fluid proximate to an end of the sheath within the sheath.

Provided is a medical wire including: a main wire-strand portion that is formed of a plurality of main wire strands and that extends over the entire length of the medical wire; and at least one sub wire-strand portion that is disposed at an outer circumference of the main wire-strand portion, that is secured to the main wire-strand portion, and that is formed of a sub wire strand, wherein the diameter of the sub wire strand is at least twice the diameter of the main wire strand, and a first region having a relatively small lateral cross-sectional area and a second region having a lateral cross-sectional area that is greater than that of the first region are included.

A guide extension catheter includes a push member and a distal shaft coupled to and extending distally from the push member. The distal shaft includes a shaft wall and a passageway. The shaft wall includes a helically-shaped proximal end and a distal end. The helically-shaped proximal end coils helically about a first central longitudinal axis of the passageway of the distal shaft. The helically-shaped proximal end of the shaft wall defines a helically-shaped entry port of the distal shaft. The distal shaft may include a helically-shaped collar coupled to the helically-shaped proximal end of the distal shaft, the collar defining the helically-shaped entry port of the distal shaft.

A manipulation rope having an excellent torque transmittability is provided. A manipulation rope 2 is a rope 2 that is advantageously used as a manipulation rope for a medical instrument, and includes a side wire 6 or a side strand which is an outermost layer, the side wire 6 or the side strand having a spiral shape in which a flatness that is an aspect ratio obtained by a major axis being divided by a minor axis is greater than 1.00 and not greater than 1.10. An elongation of the rope at a time when a tensile load that is 1.0% of a breaking load is applied, is preferably not less than 0.04% and preferably not greater than 0.10%.

A guidewire having a first region having a first property, a second region having a second property different than the first property and a joint formed by a niobium coated nickel titanium alloy sleeve joined onto a first section of the first region and a second section of the second region. A method of joining two metal components for forming a guidewire is also provided including placing a first and second metal component into a sleeve, the first sleeve composed of a nickel titanium alloy and having niobium deposited thereon, and increasing the temperature of the first sleeve so the niobium reacts to form a joint joining the first and second components.

A catheter (100) includes a resin-made distal tip (80) linked to a distal end of a catheter body (10), and the distal tip (80) has a distal lumen (81) having an open distal end. The distal lumen (81) communicates with a lumen (31). The catheter (100) is an inactive type microcatheter in which an outer diameter of the distal end of the catheter body (10) is 0.6 mm or smaller and a maximum outer diameter of the distal tip (80) is 0.6 nun or smaller. A dimension of a marker (70) in an axial direction of the catheter body (10) is smaller than the maximum outer diameter of the distal tip (80), and the length of the distal tip (80) in the axial direction of the distal tip (80) is 3 times to 18 times the maximum outer diameter of the distal tip (80).

A manipulation rope having an excellent torque transmittability is provided. A manipulation rope is a rope that is advantageously used as a manipulation rope for a medical instrument, and includes a side wire or a side strand which is an outermost layer, the side wire or the side strand having a forming rate that is greater than 100% and not greater than 110%. The side wire or the side strand having been formed has a spiral shape in which a flatness that is an aspect ratio obtained by a major axis being divided by a minor axis is preferably not less than 1.01 and preferably not greater than 1.10. Further, an elongation of the rope at a time when a tensile load that is 1.0% of a breaking load is applied, is preferably not less than 0.04% and preferably not greater than 0.10%.

A connection structure includes a multi-thread coil formed by winding first metal element wires formed of a first metal and second metal element wires formed of a second metal arranged between a first metal body including the first metal and a second metal body including the second metal. The first metal body is connected to the first metal element wires of the multi-thread coil, and the second metal body is connected to the second metal element wires of the multi-thread coil. The connection structure imparts improved flexibility to the connection between the first and second metal bodies, and an appropriate connection can be provided even when the first and second metal bodies are made of dissimilar metals.

Devices, systems, and methods for articulating elongate flexible structures such as catheters optionally include an array of fluid-expandable bodies such as balloons. The array can be formed using separate strings of balloons formed along single-lumen balloon tube material. The balloon strings can be twisted together to form a multi-channel bundle, or the balloon strings may be circumferentially separated, each extending axially. Regardless, the balloons along a common lumen may be aligned so as to bend the catheter in a desired lateral direction. The fluid-expandable bodies may include an elastomeric bladder with a fiber braid so that inflation of the bladder shortens the assembly and applies axial tension to articulate the catheter. The elongate flexible structures may be pre-biased so as to form a bend when in a relaxed configuration, with the structures being articulatable from the bend.