The disclosure relates to devices and methods for the treatment of edema using a purge-free system. The invention provides devices and methods useful for treating edema by means of an indwelling catheter that is placed in a blood vessel of a patient and used to pump blood to cause a decrease in pressure at an outlet of a lymphatic duct. The catheter pumps blood by means of an impeller but is purge-free in that the catheter does not include a system for purging or flushing catheter components with a purge fluid. The purge-free catheter avoids blood-related mechanical complications such as clotting or thrombosis by means of an impermeable sleeve or shroud that protects moving parts of the impeller drive system.

Systems for imparting pulsatile energy to cardiovascular tissue are provided. Aspects of the systems include a console assembly comprising a potential source, a manifold assembly operably connected to an output of the console assembly, wherein the manifold assembly comprises an oscillator configured to generate pulse energy from energy transmitted from the potential source and a catheter assembly operably connected to an output of the manifold assembly. Catheter assemblies of the present invention include a connector operably connecting the catheter assembly to the manifold assembly and configured to transduce a first pulse energy generated by the manifold assembly to a second pulse energy, a catheter comprising a fluidic passage operably connected to the output of the connector and configured to transmit the second pulse energy and a heart-tissue-conforming element configured to receive the second pulse energy transmitted through the fluidic passage of the catheter to apply pulsatile energy to cardiovascular tissue. Also provided are methods for imparting pulsatile energy to cardiovascular tissue, e.g., deploying a system so that a heart-tissue-conforming element of the system is adjacent to cardiovascular tissue and engaging the system in a manner that the heart-tissue-conforming element imparts energy to the cardiovascular tissue. In addition, standalone catheter assemblies as well as kits comprising components of the systems described herein are provided. The systems, assemblies, methods and kits find use in a variety of different applications, including balloon angioplasty applications or other catheter-based therapies or treatments.

An occlusion catheter system includes an inflation catheter member and an occlusion balloon. The proximal and distal balloon ends are connected to the inflation catheter between the proximal and distal catheter ends. A distal pressure sensor is attached to the inflation catheter member between the proximal balloon end and the atraumatic tip. An inflatable spine is connected to the inflation catheter. The proximal spine end is connected to the inflation catheter near the proximal balloon end and the distal spine end is connected to the inflation catheter near the distal balloon end. The occlusion balloon and the inflatable spine are configured to define blood flow channels with the internal surface and the external balloon surface when the occlusion catheter system is at least partially positioned in the vessel and the occlusion balloon and the inflatable spine are in a partially inflated configuration.

Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure. The inflatable structures are formed of a plurality of balloons arranged radially around a central location. The plurality of balloons form a lumen through which blood flows. Each balloon of the plurality is shaped or configured to stabilize the adjacent balloons, limiting their movement relative to each other. For example, some embodiments can feature balloons with a keystone shape that limits movement of the balloons inward toward the lumen. Some implementations can also include a support coil running through the lumen. The support coil holds enables the lumen to be open to perfusion even in the early stages of balloon inflation.

An embodiment provides a method for normalizing cardiac venous return, including: inserting percutaneously a calibrated balloon catheter through a femoral vein; advancing the calibrated balloon catheter to the inferior vena cava; and placing a balloon portion of the calibrated balloon catheter at a location before the drainage point of the hepatic vein.

Embolization particles can be safely delivered to the left gastric artery of a patient by introducing the distal end of a catheter in the patient's left gastric artery, inflating a balloon located near the distal end of the catheter so that the balloon prevents blood from flowing through the left gastric artery, and injecting a mixture of particles and contrast agent into the proximal end of the catheter so that they flow through the catheter. In addition, a path is provided for blood to flow into the catheter through an opening in the sidewall of the catheter at a position that is proximal to the balloon, and out through the distal end of the catheter. This blood flow helps to carry the particles along to their destination in the distal portion of the left gastric artery. The particles are also prevented from flowing into portions of the patient's artery system that are proximal of the balloon.

A catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially the contrast-induced acute kidney injury wherein the devices prevent the contrast dyes from entering into kidney and/or facilitate blood flow of kidney by said catheter system.

A vascular catheter includes a catheter shaft having a distal end, a proximal end, a handle, at least two occlusion elements adapted to isolate a volume of the blood vessel, and an expandable balloon, between the two occlusion elements. The catheter shaft includes a first hole that opens into the expandable balloon. The catheter handle includes a first pumping device associated with a first path and with a first tank containing a first fluid, a second pumping device associated with a second path and with a second tank containing a second fluid, and a synchronization device connectable both to the first and to the second pumping devices.

Devices, systems, and methods for treating a blood flow passage are discloses herein. In one example, a treatment device includes an expandable element configured to be positioned within the passage and a reinforcing element. The expandable element may have an expanded configuration in which the expandable element defines a lumen therethrough. The reinforcing element may be positioned within the lumen of the expandable element. The reinforcing element may be coupled to the expandable element such that expansion of the expandable element causes the reinforcing element to radially expand, thereby creating a perfusion lumen through the device.

In some examples, a catheter includes one or more balloons that, when inflated, are configured to be apposition with vasculature or other hollow anatomical structure of a patient to help anchor the catheter within the vasculature, while still permitting fluid to flow past the inflated balloons. When inflated, the one or more balloons define one or more passageways configured to enable fluid to flow past the inflated balloons in a direction along a longitudinal axis of the catheter. For example, the catheter may comprise a plurality of balloons that are circumferentially and longitudinally staggered relative to each other.