Methods and devices for accurately pumping small quantities of liquid to a patient with a broad range of flow and low cost.

A needleless connector may include a housing comprising a central longitudinal axis, a body portion, and a base portion. The body portion may include an inner surface forming an internal cavity, and a first port forming a first fluid passage to the internal cavity. The base portion may include a top section including a valve seal support, and a bottom section including a second port forming a second fluid passage to the internal cavity. The needleless connector may further include an asymmetrically-shaped valve disposed in the internal cavity. The asymmetrically-shaped valve may include a head portion, a valve body portion extending distally from the head portion, and a wall having an inner surface forming a valve cavity. The valve may be coupled with the housing such that the inner surface of the valve at the valve body portion is seated and radially supported on the valve seal support.

A needleless connector may include a housing having a proximal end, a distal end, and an inner surface defining an internal cavity extending between the proximal and distal ends. A compressible valve may be disposed within the internal cavity. The compressible valve may include a head portion, a flange portion for securing the compressible valve in the housing, and a body portion extending between the head portion and the flange portion. The body portion may include a cylindrical outer surface having an external notch extending along a portion of a circumference of the cylindrical outer surface and recessed radially-inward from the cylindrical outer surface. The body portion may further include a planar face extending distally from the external notch and disposed between the external notch and the flange portion. The planar face may be recessed radially inward relative to at least a portion of the cylindrical outer surface.

Methods and devices for accurately pumping small quantities of liquid to a patient with a broad range of flow and low cost.

Certain embodiments provide multi-medicament or single medicament infusion systems for preventing the cross-channeling or improper delivery of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The medicament cartridges may be sized and shaped differently such that the medicament reservoirs can only be inserted into the pump under selected configurations.

Needleless connectors are described. An example needleless connector includes a housing and a compressible valve. The housing may define an internal cavity and may include a body section having a first port and one or more internal contact tabs and a base section having a valve mount and a second port. The compressible valve may be disposed within at least a portion of the internal cavity and be movably retained within the housing. The compressible valve may include a flange portion for securing the compressible valve within the housing. A central longitudinal axis of the housing may be defined by a coaxial arrangement of the first and second port. The one or more internal contact tabs may be arranged to contact an outer side surface of the flange portion such that a radial force substantially orthogonal to the central longitudinal axis is provided for securement.

Certain embodiments provide multi-medicament or single medicament infusion systems for preventing the cross-channeling or improper delivery of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The medicament cartridges may be sized and shaped differently such that the medicament reservoirs can only be inserted into the pump under selected configurations.

A valve for controlling material flow through a catheter, comprises a first flexible member including a first moveable element, wherein, when the first moveable element is in the open position, material may flow past the first flexible member through a first lumen of the catheter and, when the first moveable element is in the closed position, flow through the first lumen is prevented and a first biasing member coupled to the first flexible member for biasing the first moveable member toward the closed position.

A flow restriction device may include a distal end configured to couple to a catheter assembly, a proximal end configured to couple to a fluid collection device, and a body extending from the proximal end to the distal end. The body may include an outer surface and an inner surface defining a lumen of the body. The flow restriction device may further include a fluid pathway disposed between the distal end and the proximal end when the outer surface is coupled within a mating luer. The fluid pathway may include a non-linear portion on at least a portion of the outer surface along which a fluid flows from the distal end into the fluid collection device.

Systems and methods for performing aspiration thrombectomy. The aspiration catheter assembly can include a support catheter and an aspiration catheter extending through the support catheter. The catheter assembly can include a distal valve apparatus that can control a level of vacuum at a distal end of the catheter system. Irrigation can flow between the support catheter and the aspiration catheter to flush the catheter assembly.