Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A pump cassette is disclosed. The pump cassette includes a housing having at least one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump. The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

Non-removable connection system (100) for a medical apparatus comprising a first connector (1) comprising a fluid coupling portion (2), a second connector (11) comprising a respective fluid coupling portion (12) connectable to the fluid coupling portion (2) of the first connector (1), wherein the second connector (11) comprises a hooking portion (13) and at least one locking projection (14). The non-removable connection system (100) also comprises a collar (20) coupled to the first connector (1) and comprising a respective hooking portion (23) engageable to the hooking portion (13) of the second connector (11) through an engagement rotation (ER), wherein in a engaged configuration the hooking portions (23, 13) prevent axial removal of the collar (20) from the second connector (11). The collar (20) further comprises respective locking projections (24) engageable to the locking projections (14) of the second connector (11) through the engagement rotation; in a coupled configuration the locking projections (24, 14) prevent a disengagement rotation of the collar (20) with respect to the second connector (11).

Non-removable connection system (100) for a medical apparatus comprising a first connector (1) comprising a fluid coupling portion (2), a second connector (11) comprising a respective fluid coupling portion (12) connectable to the fluid coupling portion (2) of the first connector (1), wherein the second connector (11) comprises a hooking portion (13) and at least one locking projection (14). The non-removable connection system (100) also comprises a collar (20) coupled to the first connector (1) and comprising a respective hooking portion (23) engageable to the hooking portion (13) of the second connector (11) through an engagement rotation (ER), wherein in a engaged configuration the hooking portions (23, 13) prevent axial removal of the collar (20) from the second connector (11). The collar (20) further comprises respective locking projections (24) engageable to the locking projections (14) of the second connector (11) through the engagement rotation; in a coupled configuration the locking projections (24, 14) prevent a disengagement rotation of the collar (20) with respect to the second connector (11).

A connecting piece having a transfer apparatus for data transfer and/or for transferring electrical energy with the counter connecting piece. A connecting piece of this type is preferably used in an intelligent medical fluid conduction and transfer system, in which various components are interconnected by means of the connecting pieces not only fluidically but also for the purpose of transferring energy and/or data with each other, such that, for example, information regarding the medication can be exchanged or validated.

A connecting piece having a transfer apparatus for data transfer and/or for transferring electrical energy with the counter connecting piece. A connecting piece of this type is preferably used in an intelligent medical fluid conduction and transfer system, in which various components are interconnected by means of the connecting pieces not only fluidically but also for the purpose of transferring energy and/or data with each other, such that, for example, information regarding the medication can be exchanged or validated.

A system includes a device having a blood side, a solution side, and a semipermeable membrane structurally configured for diffusion of one or more solutes therethrough. The system also includes a first extracorporeal circuit having one or more first fluid connectors for connecting the blood side of the device to the vascular system of a first animal, a second extracorporeal circuit including one or more second fluid connectors for connecting the solution side of the device to the vascular system of a second animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source.

A blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the speed of blood and the wall shear stress in a peripheral vein or artery for a period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. The blood pump system includes a blood pump, blood conduit(s), a control system with optional sensors, and a power source. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate and pulsatility. The pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood speed, wall shear stress, and desired pulsatility in the target vessel to optimize the rate and extent of persistent increase in the overall diameter and lumen diameter of the target vessel.

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or to vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of an apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of the diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber.