An extracorporeal blood line set for a blood treatment machine or as part of a blood treatment machine, especially a dialysis machine. The extracorporeal blood line set includes an arterial blood line having a distal patient access and a proximal device port, preferably a dialyzer port, a venous blood line having a distal patient access and a proximal device port, preferably a dialyzer port, and at least one fluid supply line which is connected to the arterial and/or venous blood line(s) in at least one port section of the arterial and/or venous blood line(s) and at one end includes a container port or a fluid container. The at least one port section is in the form of a Venturi nozzle.

Automated control mechanisms and methods for controlling fluid flow in a hemodialysis apparatus are described. The methods can involve a controller receiving information from a pressure sensor in a control chamber of a reciprocating diaphragm-based blood pump and causing the application of a time-varying pressure waveform on a diaphragm of the blood pump during a fill-stroke of the blood pump. The controller can be configured and programmed to monitor a pressure variation in the control chamber measured by the pressure sensor and to compare the measured pressure variation to a pre-determined value. Based on such comparison, the controller can initiate a procedure to pause or stop a dialysate pump of the hemodialysis apparatus if the magnitude of the measured pressure variation deviates from the pre-determined value.

Automated control mechanisms and methods for controlling fluid flow in a hemodialysis apparatus are described. The methods can involve a controller receiving information from a pressure sensor in a control chamber of a reciprocating diaphragm-based blood pump and causing the application of a time-varying pressure waveform on a diaphragm of the blood pump during a fill-stroke of the blood pump. The controller can be configured and programmed to monitor a pressure variation in the control chamber measured by the pressure sensor and to compare the measured pressure variation to a pre-determined value. Based on such comparison, the controller can initiate a procedure to pause or stop a dialysate pump of the hemodialysis apparatus if the magnitude of the measured pressure variation deviates from the pre-determined value.

A dialysis cassette includes a cassette housing having a plurality of channels fluidly coupled to a plurality of connectors and a plurality of valves disposed within the plurality of channels. The dialysis cassette also includes a pump assembly disposed within the cassette housing. The pump assembly includes a pump housing and a flexible rotor having a plurality of flexible vanes, where the flexible rotor is rotatable in either a clockwise direction or a counterclockwise direction to move a fluid through the plurality of channels.

A dialysis cassette includes a cassette housing having a plurality of channels fluidly coupled to a plurality of connectors and a plurality of valves disposed within the plurality of channels. The dialysis cassette also includes a pump assembly disposed within the cassette housing. The pump assembly includes a pump housing and a flexible rotor having a plurality of flexible vanes, where the flexible rotor is rotatable in either a clockwise direction or a counterclockwise direction to move a fluid through the plurality of channels.

A dialysis apparatus has a connection channel that communicatively connects a dialysate circuit and a blood circuit, and circulates dialysate from the dialysate circuit to the blood circuit via the connection channel during a priming operation. A blood pump has a tube attachment device that switches from an unattached state in which a tube is positioned outside a housing and permits liquid to circulate thereinside, to an attached state in which the tube is in the housing and a rotor compresses the tube. At the time of priming, the liquid feeding pump feeds dialysate from the dialysate circuit to the blood circuit via the connection channel. With the blood pump being in the unattached state, the dialysate is circulated past the blood pump, and then, with the blood pump in the attached state, the dialysate is circulated in a direction opposite to the blood pump.

A proportioning device includes a proportioning machine with a temperature-compensating conductivity sensor, a controller, and pump actuator. A fluid circuit is engageable with the pump actuator, has connections for a source of water and one or more medicament concentrates, and includes a mixing container. The controller is configured to mix contents of the mixing container at a first time and to sample fluid from the mixing container, to pass the samples from the mixing container through the temperature-compensating conductivity sensor at different points in time as the fluid flows from the mixing container. The controller is further configured to mix contents of the mixing container a second time if the conductivities differ by a predefined magnitude.

A proportioning device includes a proportioning machine with a temperature-compensating conductivity sensor, a controller, and pump actuator. A fluid circuit is engageable with the pump actuator, has connections for a source of water and one or more medicament concentrates, and includes a mixing container. The controller is configured to mix contents of the mixing container at a first time and to sample fluid from the mixing container, to pass the samples from the mixing container through the temperature-compensating conductivity sensor at different points in time as the fluid flows from the mixing container. The controller is further configured to mix contents of the mixing container a second time if the conductivities differ by a predefined magnitude.

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

The invention relates to a membrane pump device 2 for conveying fluids, in particular medical liquids for blood treatment. The invention furthermore relates to a membrane pump with a membrane pump device 2 and an actuating device 1 for the membrane pump device 2. The membrane pump device 2 has a pump chamber body 253 in which a recess, which is closed by an elastic membrane 201 to form a pump chamber 252, is constructed. The membrane pump device 2 moreover comprises an inward flow path 219 which connects an entry connection 204 to an inlet opening 215 of the pump chamber 252, and an outward flow path 223 which connects an outlet opening 216 of the pump chamber 252 to an exit connection 205. An inlet valve 202 is provided in the inward flow path 219 and an outlet valve 203 is provided in the outward flow path 223. The outlet valve 203 is a membrane valve which has a valve body 254A in which a recess is constructed which is closed by an elastic membrane 201 to form a valve chamber 218 in which a valve seat 225 is arranged, the front face of which faces the membrane and in the open position of the outlet valve is arranged at a distance from the valve seat, wherein a valve channel 240 passes through the valve seat. The outward flow path 223 comprises a first outward flow channel 214 which connects the outlet opening 216 of the pump chamber 252 to the outlet valve chamber 218, and a second outward flow channel 214A which connects the outlet valve chamber 240 to the exit connection 205, wherein the cross-section area of the outlet valve channel 240 is smaller than the cross-section area of the region of the valve chamber 218 surrounding the outlet valve seat 225.