The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and/or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.

Apparatus and methods are described including a left-ventricular assist device that includes an impeller configured to be placed inside a subject's left ventricle and to pump blood from the left ventricle to the subject's aorta, by rotating. A frame is disposed around the impeller. A tube traverses the subject's aortic valve, such that a proximal portion of the tube is disposed within the aorta and a distal portion of the tube is disposed within the left ventricle. The distal portion of the tube extends to the distal end of the frame and defines more than 10 blood-inlet openings that are sized such as (a) to allow blood to flow from the subject's left ventricle into the tube and (b) to block structures from the subject's left ventricle from entering into the frame. Other applications are also described.

This invention concerns an intravascular blood pump for percutaneous insertion into a patient's blood vessel. The blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet, an impeller arranged in said pump casing so as to be rotatable about an axis of rotation. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump comprises a drive unit for rotating the impeller, the drive unit comprising a plurality of posts arranged about the axis of rotation and a back plate connecting rear ends of the parts, the posts and the back plate together forming a magnetic core of the drive unit. A coil winding is disposed around each of the posts. The coil windings are controllable so as to create a rotating magnetic field, wherein the impeller comprises a magnetic structure arranged to interact with the rotating magnetic field so as to cause rotation of the impeller. The magnetic core or a part of it comprises a discontinuous soft magnetic material which is discontinuous regarding electric conductivity in a cross-section, wherein at least one weld is provided at a surface of the discontinuous soft magnetic material. The weld bridges at least one discontinuity regarding electric conductivity in the discontinuous soft magnetic material. Further, the invention concerns a method of manufacturing the magnetic core.

This invention concerns an intravascular blood pump for percutaneous insertion into a patient's blood vessel. The blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet, an impeller arranged in said pump casing so as to be rotatable about an axis of rotation. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump comprises a drive unit for rotating the impeller, the drive unit comprising a magnetic core including a plurality of posts arranged about the axis of rotation and a back plate connecting the posts and extending between the posts in an intermediate area. A coil winding is disposed around each of the posts. The coil windings are controllable so as to create a rotating magnetic field, wherein the impeller comprises a magnetic structure arranged to interact with the rotating magnetic field so as to cause rotation of the impeller. A material of at least a portion of at least one of the posts is integral with a material of the intermediate area of the back plate. Further, the invention concerns a method of manufacturing a magnetic core and a method of manufacturing an intravascular blood pump.

Catheter blood pumps that include an expandable pump portion, which include an expandable impeller housing. The housings include an expandable blood conduit that defines a blood lumen, and one or more pluralities of expandable struts extending axially from an end region of the expandable blood conduit. At least one of the pluralities of struts are non-unitary with a blood conduit at the end region.

This invention concerns an intravascular blood pump for percutaneous insertion into a patient's blood vessel. The blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet, and an impeller arranged in said pump casing so as to be rotatable about an axis of rotation. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump comprises a drive unit for rotating the impeller, the drive unit comprising a plurality of posts arranged about the axis of rotation. Each of the posts has a longitudinal axis and an impeller-side end pointing towards the impeller. A coil winding is disposed around each of the posts and has an impeller-side end pointing towards the impeller. The coil windings are controllable so as to create a rotating magnetic field, wherein the impeller comprises a magnetic structure arranged to interact with the rotating magnetic field so as to cause rotation of the impeller. The posts do not extend with their impeller-side ends radially over the impeller-side ends of the coil winding disposed around the respective posts, wherein the term radially relates to the longitudinal axis of the posts.

This invention concerns an intravascular blood pump for percutaneous insertion into a patient's blood vessel. The blood pump comprises a pump casing having a blood flow inlet and a blood flow outlet, and an impeller arranged in said pump casing so as to be rotatable about an axis of rotation. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump comprises a drive unit for rotating the impeller, the drive unit comprising a plurality of posts arranged about the axis of rotation and a back plate. A coil winding is disposed around each of the posts and has an impeller-side end pointing towards the impeller. The coil windings are controllable so as to create a rotating magnetic field, wherein the impeller comprises a magnetic structure arranged to interact with the rotating magnetic field so as to cause rotation of the impeller. The rear end surfaces of the posts contact the back plate.

An intravascular fluid movement device that includes an expandable member having a collapsed, delivery configuration and an expanded, deployed configuration, the expandable member having a proximal end and a distal end, a rotatable member disposed radially and axially within the expandable member, and a conduit coupled to the expandable member, the conduit at least partially defining a blood flow lumen between a distal end of the conduit and a proximal end of the conduit, the conduit disposed solely radially inside of the expandable member in a distal section of the expandable member.

A magnetic levitation centrifugal pump, comprises: one hollow body provided with at least one inlet connector and with at least one outlet connector for blood; one rotor element, housed inside the hollow body and comprising at least one magnetic portion, where the rotor element can be commanded in rotation about an axis of rotation, without contact, by a stator element associable with the hollow body, the rotor element comprising at least one revolving body, which defines an upper surface supporting a plurality of blades which are adapted to convey blood towards the outlet connector; where the upper surface has a substantially concave shape and where the revolving body comprises at least one through hole which is positioned along the axis of rotation.

An intravascular fluid movement device that includes an expandable member having a collapsed, delivery configuration and an expanded, deployed configuration, the expandable member having a proximal end and a distal end, a rotatable member disposed radially and axially within the expandable member, and a conduit coupled to the expandable member, the conduit at least partially defining a blood flow lumen between a distal end of the conduit and a proximal end of the conduit, the conduit disposed solely radially inside of the expandable member in a distal section of the expandable member.