A system for supplying power transcutaneously to an implantable device implanted within a subject is provided. The system includes an external connector including one of a microneedle array and a microwire holder. The system further includes a power cable electrically coupled to the external connector and configured to supply power to the one of the microneedle array and the microwire holder, and an internal connector configured to be implanted within the subject and electrically coupled to the implantable device, the internal connector including the other of the microneedle array and the microwire holder. The microneedle array includes a plurality of electrically conductive microneedles, the microwire holder includes a plurality of electrical contacts, and the microwire holder is configured to engage the microneedle array such that the plurality of electrically conductive microneedles extend through the skin of the subject and electrically couple to the plurality of electrical contacts.

An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.

Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.

Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as ventricular assistance and transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.

A system for extracorporeal organ support can include an organ chamber and a cross-circulation circuit. The organ camber can be configured to hold an extracorporeal organ. The cross-circulation circuit be configured to connect the extracorporeal organ and a host organism to maintain the extracorporeal organ by perfusing veno-arterial-venous (V-AV) blood through the extracorporeal organ and the host organism, wherein physiologic stability of the host organism is maintained.

A system for extracorporeal organ support can include an organ chamber and a cross-circulation circuit. The organ camber can be configured to hold an extracorporeal organ. The cross-circulation circuit be configured to connect the extracorporeal organ and a host organism to maintain the extracorporeal organ by perfusing veno-arterial-venous (V-AV) blood through the extracorporeal organ and the host organism, wherein physiologic stability of the host organism is maintained.

Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as ventricular assistance and transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.

This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device system for treating a heart, includes a control system including a processor and a pump, a hub coupled to the control system, a catheter shaft having a lumen and a first end coupled to the hub, a first expandable member disposed on the catheter shaft, wherein the first expandable member is configured to be positioned in the superior vena cava and a second expandable member disposed on the catheter shaft. Further, the second expandable member is configured to be positioned in the inferior vena cava and the catheter shaft includes a first aperture configured to permit an auxiliary medical device to pass from the lumen into the right atrium of the heart.

This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device system for treating a heart, includes a control system including a processor and a pump, a hub coupled to the control system, a control system including a processor and a pump, a hub coupled to the control system, a first catheter shaft having a first lumen and a first end coupled to the hub, a second catheter shaft extending within the first lumen and having a first end couple to the hub, a first expandable member disposed on the first catheter shaft, wherein the first expandable member is configured to be positioned in the superior vena cava and a second expandable member disposed on the second catheter shaft distal to the first expandable member, wherein the second expandable member is configured to translate relative to the first expandable member.

This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device system for treating a heart, includes a control system including a processor and a pump, a hub coupled to the control system, a control system including a processor and a pump, a hub coupled to the control system, a first catheter shaft having a first lumen and a first end coupled to the hub, a second catheter shaft extending within the first lumen and having a first end couple to the hub, a first expandable member disposed on the first catheter shaft, wherein the first expandable member is configured to be positioned in the superior vena cava and a second expandable member disposed on the second catheter shaft distal to the first expandable member, wherein the second expandable member is configured to translate relative to the first expandable member.