A pump cassette is disclosed. The pump cassette includes a housing having at least one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump. The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

A process fluid pump can include a pump chamber, an inlet valve, and an outlet valve. Diaphragm regions can define at least a portion of each of the pump chamber, the inlet valve, and the outlet valve. The diaphragm regions can each have an actuation region with a surface that is convexly shaped when the formed actuation region is in a natural unstressed first state, and each formed actuation region can be actuated by a motive fluid to transition to a second state in which the surface is non-convexly shaped.

A medical fluid pumping system includes (i) a medical fluid pump including a pump chamber, inlet and outlet valve chambers in fluid communication with the pump chamber, the pump chamber associated with a pumping chamber motive fluid connection, the inlet valve chamber associated with an inlet valve motive fluid connection, and the outlet valve chamber associated with an outlet valve motive fluid connection; and (ii) a medical fluid chassis including a motive fluid source, and a first motive fluid connecting structure, a second motive fluid connecting structure, a third motive fluid connecting structure. The pumping chamber motive fluid connection, the inlet valve motive fluid connection, and the outlet valve motive fluid connection are translated simultaneously to mate respectively with the first motive fluid connecting structure, the second motive fluid connecting structure, and the third motive fluid connecting structure for fluid communication with the motive fluid source.

An operational unit for locating and neutralizing pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, the pump is operated to move the identified cells to a processing zone. When each identified cell reaches the processing zone, electric energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a treatment time period.

An operational unit for locating and neutralizing pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, the pump is operated to move the identified cells to a processing zone. When each identified cell reaches the processing zone, electric energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a treatment time period.

A method, related system and apparatus are disclosed. The method is implemented by an operative set of processor executable instructions configured for execution by a processor. The method includes the acts of: determining if a monitoring client is connected to a base through a physical connection; establishing a first communications link between the monitoring client and the base through the physical connection; updating, if necessary, the interface program on the monitoring client and the base through the first communications link; establishing a second communications link between the monitoring client and the base using the first communications link; and communicating data from the base to the monitoring client using the second communications link.

A method, related system and apparatus are disclosed. The method is implemented by an operative set of processor executable instructions configured for execution by a processor. The method includes the acts of: determining if a monitoring client is connected to a base through a physical connection; establishing a first communications link between the monitoring client and the base through the physical connection; updating, if necessary, the interface program on the monitoring client and the base through the first communications link; establishing a second communications link between the monitoring client and the base using the first communications link; and communicating data from the base to the monitoring client using the second communications link.

A pneumatic system for a medical fluid machine operating a medical fluid cassette, the pneumatic system including an interface for supplying positive pneumatic pressure and negative pneumatic pressure to the medical fluid cassette; a source of positive pneumatic pressure; a source of negative pneumatic pressure; and a pneumatic pump including a first head and a second head, wherein the first head is dedicated to supplying positive pneumatic pressure to the positive pneumatic pressure source and the second head is dedicated to supplying negative pneumatic pressure to the negative pneumatic pressure source.

A medical fluid delivery device includes a process fluid body including first and second sides defining a first process fluid inlet valve seat and a first process fluid outlet valve seat and a second process fluid inlet valve seat and a second process fluid outlet valve seat; a first motive fluid plate defining a first aligned motive fluid inlet valve actuation area and a first aligned motive fluid outlet valve actuation area; and a second motive fluid plate defining a second aligned motive fluid inlet valve actuation area and a second aligned motive fluid outlet valve actuation area. The device further includes a first inlet valve diaphragm disposed between the first motive fluid inlet valve actuation area and the first process fluid inlet valve seat; and a first outlet valve diaphragm disposed between the first motive fluid outlet valve actuation area and the first process fluid outlet valve seat.

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat.