Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A blood pump comprising a cartridge, the cartridge comprising a first recess therein, said first recess having a surface, and a flexible diaphragm closing said first recess, the first recess and the flexible diaphragm defining a first pump chamber, said first pump chamber having an inlet and an outlet wherein the flexible diaphragm of the first pump chamber is movable between a first position, separated in use from the surface of the first recess, in which said first pump chamber has a maximum volume, and a second position, substantially adjacent to the surface of the first recess, in which said first pump chamber has a minimum volume a pump driver arranged to interface with the cartridge, said pump driver operable to move the flexible diaphragm of the first pump chamber in a first direction into said first recess to, in use, pump blood from the chamber and to move the flexible diaphragm of the first pump chamber in a second direction away from the first recess to, in use, draw blood into said first pump chamber, wherein the pump driver controls the movement of the flexible diaphragm of the first pump chamber such that the flexible diaphragm of the first pump chamber moves toward said first position at a first speed and moves toward said second position at a second speed, said second speed being greater than said first speed.

A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

An adaptor for use in a blood conduit of an extracorporeal life support system. The adaptor includes a body defining a main passageway and an auxiliary port extending from the body with a passageway of the auxiliary port converging with the main passageway. The auxiliary port includes a hemostasis valve configured to selectively seal around a medical device inserted through the auxiliary port into the main passageway. An elastomeric valve may be positioned in the passageway of the auxiliary port spaced away from the hemostasis valve such that elastomeric valve is located between the hemostasis valve and the main passageway. In some instances, the hemostasis valve may be removably couplable to the auxiliary port.

An adaptor for use in a blood conduit of an extracorporeal life support system. The adaptor includes a body defining a main passageway and an auxiliary port extending from the body with a passageway of the auxiliary port converging with the main passageway. The auxiliary port includes a hemostasis valve configured to selectively seal around a medical device inserted through the auxiliary port into the main passageway. An elastomeric valve may be positioned in the passageway of the auxiliary port spaced away from the hemostasis valve such that elastomeric valve is located between the hemostasis valve and the main passageway. In some instances, the hemostasis valve may be removably couplable to the auxiliary port.

The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient.

The invention relates to an arrangement having a blood pump and a gas exchanger for extracorporeal membrane oxygenation. According to the invention, the blood pump is designed as a pulsatile blood pump and is arranged with the gas exchanger in the same housing. The pulsatile blood pump and the gas exchanger are preferably connected to the same gas source so that the blood pump can be pneumatically driven. The novel ECMO system has a simple design, is flexible, and in particular can be used directly on the patient.