The invention relates to a device for circulatory support of the heart and to a corresponding method with a holding means which is configured such that it can be implanted intracardially in the left and/or right ventricular outflow tract of the heart by means of a catheter, preferably using an endovascular method, through a femoral access and/or a percutaneous transventricular, transseptal, transapical or transvenous access, wherein the holding means comprises an anchoring means which can be fixed in the subcommissural triangle underneath the aortic valve and the pulmonary valve, respectively in the flow direction of the blood on the ventricular side of the aortic valve and the pulmonary valve, respectively, a pump which is configured such that it can be fixed in the holding means by means of a catheter, preferably using an endovascular method, through a femoral access and/or a percutaneous transventricular, transseptal, transapical or transvenous access, wherein the pump (a) can either be inserted releasably into the holding means after the holding means has been fixed by means of the anchoring means in the subcommissural triangles underneath the aortic valve and the pulmonary valve, respectively or (b) is firmly connected to the collapsible and expandable anchoring means.

An implantable ventricular assist device comprises an intraventricular stent used for the creation of an artificial chamber inside the ventricle, a balloon-like structure used to drive the change of the artificial chamber between a contractile configuration and a diastolic configuration, a power system used for driving the change of the balloon-like structure between the contractile configuration and the diastolic configuration. There is also a power system and a mechanical design to operate the system working, wherein in the contractile configuration, the balloon-like structure expands and occupies the space of the artificial chamber and drives the blood inside the artificial chamber flow outside the artificial chamber, wherein in the diastolic configuration, the balloon-like structure shrinks and releases the space inside the artificial chamber, and the blood outside the artificial chamber flows back into the artificial chamber. It is easy to reach the goal of cardiac function.

Devices, systems, and methods for providing retroperfusion to at least one ischemic tissue in a minimally invasive manner are disclosed. At least some of the embodiments disclosed herein enable an anastomosis to be formed between a vein and an artery without the use of sutures and through a non-invasive procedure. In addition, various disclosed embodiments provide a cannula device comprising a Y-configuration for bifurcating arterial flow between an anastomosis and the underlying artery. The devices, systems and methods herein can further provide simultaneous autoretroperfusion therapy to more than one area of an ischemic tissue.

Devices, systems and methods are described herein for sealing openings in an anatomical wall. A sealing system includes an elongate tubular support for delivery to an anatomical opening to be sealed, a cover of bio-compatible material covering a distal portion of the tubular support, and an anchor assembly, the anchor assembly being designed to secure the cover material to the opening. The anchor assembly can include a plurality of distal anchors and a plurality of proximal anchors, a button, ring or donut, and/or a C-clip. In some embodiments, the system further comprises a closure member for closing off an end of the cover material after removal of the tubular support.

Cardiac chamber prosthesis configured to be implanted in a cardiac chamber (10; 20; 30; 40) comprising a native outlet valve (50; 60; 70; 80) and at least one inlet aperture (50; 70) selected from the group comprising a native inlet valve (50; 70) and one or more outlet mouths of venae cavae or pulmonary veins (120; 125; 130), wherein the cardiac chamber prosthesis comprises: an inner elastic membrane (250; 255; 260; 650; 750; 850), a reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) comprising or consisting of an outer elastic membrane (200; 205; 600; 700; 800) provided with a plurality of clips (210) configured to grip an inner wall (45) of the cardiac chamber (10; 20; 30; 40), wherein the elastic inner and outer membranes (250, 200; 255, 205; 260, 200; 650, 600; 750, 700; 850, 800) form an outlet border (285; 675; 785; 885) configured to surround and be sutured on the native outlet valve (50; 60; 70; 80) and at least one inlet border (275; 685; 775; 875A, 875B) configured to surround and be sutured on said at least one inlet aperture (50; 70), wherein the inner elastic membrane (250; 255; 260; 650; 750; 850) and the reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) are connected to each other by means of a plurality of primary variable connection elements (290; 290B), whereby the inner elastic membrane (250; 255; 260; 650; 750; 850) and the reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) delimit a primary interspace (230; 230B; 630; 730; 830) between them that is configured to receive a fluid with varying amount and/or pressure so as to dynamically modify a volume of the primary interspace (230; 2303; 630; 730; 830) and said elastically variable volume delimited by the inner surface (254; 654; 754; 854) of the inner elastic membrane (250; 255; 260; 650; 750; 850).

Cardiac chamber prosthesis configured to be implanted in a cardiac chamber (10; 20; 30; 40) comprising a native outlet valve (50; 60; 70; 80) and at least one inlet aperture (50; 70) selected from the group comprising a native inlet valve (50; 70) and one or more outlet mouths of venae cavae or pulmonary veins (120; 125; 130), wherein the cardiac chamber prosthesis comprises: an inner elastic membrane (250; 255; 260; 650; 750; 850), a reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) comprising or consisting of an outer elastic membrane (200; 205; 600; 700; 800) provided with a plurality of clips (210) configured to grip an inner wall (45) of the cardiac chamber (10; 20; 30; 40), wherein the elastic inner and outer membranes (250, 200; 255, 205; 260, 200; 650, 600; 750, 700; 850, 800) form an outlet border (285; 675; 785; 885) configured to surround and be sutured on the native outlet valve (50; 60; 70; 80) and at least one inlet border (275; 685; 775; 875A, 875B) configured to surround and be sutured on said at least one inlet aperture (50; 70), wherein the inner elastic membrane (250; 255; 260; 650; 750; 850) and the reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) are connected to each other by means of a plurality of primary variable connection elements (290; 290B), whereby the inner elastic membrane (250; 255; 260; 650; 750; 850) and the reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) delimit a primary interspace (230; 230B; 630; 730; 830) between them that is configured to receive a fluid with varying amount and/or pressure so as to dynamically modify a volume of the primary interspace (230; 2303; 630; 730; 830) and said elastically variable volume delimited by the inner surface (254; 654; 754; 854) of the inner elastic membrane (250; 255; 260; 650; 750; 850).

A sutureless securing device for securing on an opening in a ventricular wall, includes: a hollow main body with an outer surface; a ring received at a first end of the hollow body, this ring being mobile along part of the outer surface of the hollow body; a tubular membrane covering the outer surface, whilst extending between the ring and the second end of the hollow body; a distal end of this tubular membrane, placed on the side of this second end, being self-expandable between a first configuration in which it has a tubular form, and a second configuration in which it defines a first flange extending radially, starting from the hollow body; the other end of this tubular membrane being able to be deformed by the displacement of the ring, such as to form a retention flange, the position of which can vary relative to the first flange.

A sutureless securing device for securing on an opening in a ventricular wall, includes: a hollow main body with an outer surface; a ring received at a first end of the hollow body, this ring being mobile along part of the outer surface of the hollow body; a tubular membrane covering the outer surface, whilst extending between the ring and the second end of the hollow body; a distal end of this tubular membrane, placed on the side of this second end, being self-expandable between a first configuration in which it has a tubular form, and a second configuration in which it defines a first flange extending radially, starting from the hollow body; the other end of this tubular membrane being able to be deformed by the displacement of the ring, such as to form a retention flange, the position of which can vary relative to the first flange.

Methods and devices for implanting a ventricular assist device employ a coupler that engages an aperture formed in a heart wall and provides a conduit by which blood is pumped from the ventricle via the ventricular assist device. A method includes penetrating a distal end of a delivery device through a wall of a heart into a ventricle of the heart to form an aperture having a diameter in the wall. A coupler is deployed from the delivery device so that the coupler engages the aperture, expands the diameter of the aperture, and forms a conduit for a flow of blood from the ventricle. The delivery device is removed from the ventricle by retracting the delivery device through the conduit. The ventricular assist device is coupled to the coupler to receive the flow of blood from the ventricle and pump the flow of blood to assist circulation in the patient.

Various systems and methods are provided for reducing pressure at an outflow of a duct such as the thoracic duct or the lymphatic duct. In one embodiment, an indwelling catheter can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter can include first and second restrictors each configured to at least partially occlude the vein within which the catheter is implanted and thus to restrict fluid flow within the vein when the restrictors are activated. The restrictors can each be configured to move between an activated configuration, in which the restrictor occludes the vein, and a relaxed configuration, in which the restrictor does not occlude the vein. The catheter can include a pump, such as an axial motor pump, configured to pump fluid through the catheter.