An implant system for restoring and improving physiological intracardiac flow in a human heart is provided including a force transducting, structurally stabilizing, and functionally assisting ventricular inflatable cardiac implant within a human heart for restoring and improving physiologic intracardiac flow, restoring the ventricular vortex, preventing atrioventricular pressure gradient loss, mitigating valvular regurgitation, and utilizing native energy and force, via force transduction, to restore geometric elliptical proportion and function to the atria, the ventricles and ventricular walls, and the valvular apparatus itself.

The present invention relates to a medical chamber system (700) for implantation in the chest of a patient to support the heart activity, preferably by displacing the heart apex (105), comprising at least a first chamber (702) for arrangement inside the heart sac (300) and a second chamber (701) for arrangement outside the heart sac (300), wherein the chambers (701, 702) comprise at least one connection portion or connection channel (703) which connects the two chambers (701, 702) to each other, the chambers (701, 702) and the connection channel (703) are further embodied to be filled with fluid (705) and, preferably in the implanted state, to be arranged such that the heart activity acts on the first chamber (702) and that the second chamber (701) acts as a volume storage and/or energy storage for the fluid (705). Furthermore, the present invention relates to an introduction system for a medical chamber system (700) and to a kit, encompassing a medical chamber system (700) and an introduction system.

A by-pass shunt for use with a bodily fluid pump. The by-pass shunt includes an inflow conduit, an outflow conduit, and an intermediate conduit fluidically coupling the inflow and outflow conduits. A flow restrictor is operably coupled to a portion of the intermediate conduit and is configured to reduce a fluid flow from the outflow conduit, through the intermediate conduit, and into the inflow conduit.

Cardiac chamber prosthesis configured to be implanted in a cardiac chamber (10; 20; 30; 40) comprising a native outlet valve (50; 60; 70; 80) and at least one inlet aperture (50; 70) selected from the group comprising a native inlet valve (50; 70) and one or more outlet mouths of venae cavae or pulmonary veins (120; 125; 130), wherein the cardiac chamber prosthesis comprises: an inner elastic membrane (250; 255; 260; 650; 750; 850), a reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) comprising or consisting of an outer elastic membrane (200; 205; 600; 700; 800) provided with a plurality of clips (210) configured to grip an inner wall (45) of the cardiac chamber (10; 20; 30; 40), wherein the elastic inner and outer membranes (250, 200; 255, 205; 260, 200; 650, 600; 750, 700; 850, 800) form an outlet border (285; 675; 785; 885) configured to surround and be sutured on the native outlet valve (50; 60; 70; 80) and at least one inlet border (275; 685; 775; 875A, 875B) configured to surround and be sutured on said at least one inlet aperture (50; 70), wherein the inner elastic membrane (250; 255; 260; 650; 750; 850) and the reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) are connected to each other by means of a plurality of primary variable connection elements (290; 290B), whereby the inner elastic membrane (250; 255; 260; 650; 750; 850) and the reference support elastic membrane structure (200; 205, 225, 290A; 600; 700; 800) delimit a primary interspace (230; 230B; 630; 730; 830) between them that is configured to receive a fluid with varying amount and/or pressure so as to dynamically modify a volume of the primary interspace (230; 2303; 630; 730; 830) and said elastically variable volume delimited by the inner surface (254; 654; 754; 854) of the inner elastic membrane (250; 255; 260; 650; 750; 850).

A method for repairing a heart includes identifying a heart of a patient as having a reduced ejection fraction. In response to the identifying, wall stress of a ventricle of the heart is reduced by implanting apparatus that facilitates cyclical moving of fluid that is not blood of the patient into and out of the ventricle of the heart. During ventricular diastole, a volume of the fluid is moved into the ventricle in a manner that produces a corresponding decrease in a total volume of blood that fills the ventricle during diastole. During ventricular systole, the volume of the fluid is moved out of the ventricle in a manner that produces a corresponding decrease in a total volume of the ventricle during isovolumetric contraction of the ventricle. Other embodiments are also described.

A method for repairing a heart includes identifying a heart of a patient as having a reduced ejection fraction. In response to the identifying, wall stress of a ventricle of the heart is reduced by implanting apparatus that facilitates cyclical moving of fluid that is not blood of the patient into and out of the ventricle of the heart. During ventricular diastole, a volume of the fluid is moved into the ventricle in a manner that produces a corresponding decrease in a total volume of blood that fills the ventricle during diastole. During ventricular systole, the volume of the fluid is moved out of the ventricle in a manner that produces a corresponding decrease in a total volume of the ventricle during isovolumetric contraction of the ventricle. Other embodiments are also described.

A device for reducing pulsatile pressure within a vessel to treat heart disease, such as pulmonary hypertension, includes a compliant body structured to expand and contract upon changes in pressure within the vessel, a reservoir structured for holding a fluid therein, and a conduit extending between and fluidly coupling the reservoir and the compliant body, wherein the device includes a graphene-polymer composite designed to resist diffusion of the fluid through the device.

Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.

Apparatus is provided, including a flexible intraventricular receptacle positionable within a heart ventricle, and configured to assume a first volume upon passage of fluid that is not blood into the receptacle and a second, smaller volume upon passage of the fluid out of the receptacle. An expandable extracardiac receptacle is positionable outside of the heart, and is configured to expand upon transfer of the fluid into the extracardiac receptacle from the intraventricular receptacle and to contract upon passage the fluid out of the extracardiac receptacle. A transmyocardial conduit is disposed and allows passage of the fluid between the intraventricular receptacle and the extracardiac receptacle responsively to a cardiac cycle. During ventricular systole, a volume of fluid is expelled from the intraventricular receptacle, through the conduit, and the extracardiac receptacle, producing a corresponding decrease in a total volume of the ventricle during isovolumetric contraction of the ventricle.