A multi chamber syringe unit includes a longitudinal body with side wall, distal end side, proximal end side opposite to distal end side, an interior limited by side wall between distal end side and proximal end side and distal opening arranged in distal end side for providing a liquid out of the body. The syringe further includes a separating element arranged in the interior of the body such that distal chamber and proximal chamber are formed in the interior of the body, wherein the separating element seals the distal chamber from the proximal chamber. The syringe has a bypass arrangement provided in the side wall of distal chamber of the body. A first pharmaceutical liquid is arranged in distal chamber of the body and second pharmaceutical liquid in proximal chamber of the body. The multi chamber syringe unit allows for adequately administering plural pharmaceutical liquids by injection.

Methods and systems are provided for delivering anesthetic agent to a patient. In one embodiment, an anesthetic vaporizer includes a sump configured to hold a liquid anesthetic agent; an ultrasonic transducer coupled to a bottom of the sump and at least partially disposed within the sump; a vaporizing chamber fluidically coupled to the sump; and a heating element coupled to the vaporizing chamber and configured to increase a temperature of a surface disposed within the vaporizing chamber.

Systems and methods for tracking sympathetic-driven arousal state (SDAS) including nociception under anesthesia is described herein. The method includes obtaining heart rate variability and electrodermal activity of a subject. Point process models are generated for the heart rate variability and the electrodermal activity. A multimodal approach is implemented to determine a state space framework based on these point process models. SDAS can be estimated using the state space framework. In some implementations, an anesthesiologist can modify the dosage of drugs administered to the subject based on this estimation.

Disclosed are applicators and methods injecting of a liquid anesthetic into a dental patient with no or minimal pain. In accordance with one embodiment the applicator is for intraligamentary injection and includes an elongated, thin member having an open distal free formed of a resilient and somewhat conformable material suitable for producing a substantially fluid-tight interface with the anatomic structures at the gingival sulcus to inject the anesthetic therein. In another embodiment the applicator includes a flexible skirt surrounding a sharpened cannula, with the cannula being movable with respect to the skirt. The skirt is arranged to receive the anesthetic to anesthetize the gum, whereupon the cannula can then pierce the gum to inject the anesthetic into the underlying anatomic structure.

An endotracheal tube (1) comprises a tubular body (2) having a form of a flexible curved transparent tube with open proximal (3) and distal (4) ends, a connector (7) mounted on the proximal end of the tube and served for attaching a tube cavity to a ventilation device, an inflatable cuff (9) having a cavity, said inflatable cuff fixed hermetically around the distal end of the curved tube and configured to be inflated to seal the cuff against a wall of a patient's trachea and to hold the distal end of the endotracheal tube in the desired position in a patient's larynx, a longitudinal air supply channel (10) in the wall of the tubular body, said channel being in communication with the cavity of the inflatable cuff, a sealed balloon (12) having elastic walls and configured to maintain and monitor pressure in the cuff cavity, the sealed balloon connected to an air supply port, and connected via a catheter (13) to the longitudinal air supply channel to supply an air into the cuff cavity, and a mark (14) made on the surface of the tube from the side of the proximal end at a distance of 2.5-3 cm from the inflatable cuff, wherein the inflatable cuff comprises two layers (15,16), wherein an outer layer (15) of the inflatable cuff is made of a porous biocompatible polymer material and serves as a depot for input and hold the drug in the pores of the polymer material and remove the drug from the pores of the zone of contacting of the cuff with the trachea when the cuff is inflated providing infusion of the drug into the tracheal mucosa.

An endotracheal tube (1) comprises a tubular body (2) having a form of a flexible curved transparent tube with open proximal (3) and distal (4) ends, a connector (7) mounted on the proximal end of the tube and served for attaching a tube cavity to a ventilation device, an inflatable cuff (9) having a cavity, said inflatable cuff fixed hermetically around the distal end of the curved tube and configured to be inflated to seal the cuff against a wall of a patient's trachea and to hold the distal end of the endotracheal tube in the desired position in a patient's larynx, a longitudinal air supply channel (10) in the wall of the tubular body, said channel being in communication with the cavity of the inflatable cuff, a sealed balloon (12) having elastic walls and configured to maintain and monitor pressure in the cuff cavity, the sealed balloon connected to an air supply port, and connected via a catheter (13) to the longitudinal air supply channel to supply an air into the cuff cavity, and a mark (14) made on the surface of the tube from the side of the proximal end at a distance of 2.5-3 cm from the inflatable cuff, wherein the inflatable cuff comprises two layers (15,16), wherein an outer layer (15) of the inflatable cuff is made of a porous biocompatible polymer material and serves as a depot for input and hold the drug in the pores of the polymer material and remove the drug from the pores of the zone of contacting of the cuff with the trachea when the cuff is inflated providing infusion of the drug into the tracheal mucosa.

A system and method for delivering a medicament to a target tissue site in a patient over a period of time. A catheter is configured for implantation in different target tissue sites and extends from a proximal end to a distal end and has a sidewall which defines an internal lumen. The distal end has one or more apertures either in the sidewall or at a distal end for the release of the medicament into the target tissue site; the system also comprises a medicament reservoir fluidly communicable with the internal lumen of each catheter, an adhesive member configured to adhere to the skin of the patient around the exit wound and having an opening therein to allow the catheters to pass through the adhesive member and a retaining member configured to be overlaid on the adhesive member and comprising a guide surface configured to receive a length of the two or more catheters and a plurality of retaining portions to retain the catheters against the guide surface.

Module for housing electronic and electromechanical medical equipment including a portable digital camera and processing circuitry with machine vision and machine learning software for automatically documenting healthcare events and healthcare equipment operations in the electronic health record.

An exemplary embodiment of an injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger mechanism can include a floating trigger member having a retaining portion, a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.