Embodiments of systems and methods for delivering a medicament using a pump are provided. The methods comprise inserting a first cannula into subcutaneous tissue. Medicament is delivered from a medicament pump through the first cannula according to a dosing protocol. The first cannula can removed after a period of time and a second cannula can be inserted. The method comprises modifying the dosing protocol based upon a cannula change indicator, the modifying comprising performing neural network calculations utilizing previously calculated error data, resulting in a modified dosing protocol. Medicament is delivered from the medicament pump through the second cannula according to the modified dosing protocol.

The exemplary embodiments may provide adaptivity in the basal portion value. The exemplary embodiments may also provide adaptivity of the total daily medicament (TDM) delivery amount. The adaptivity provided by the exemplary embodiments helps to customize medicament delivery to the needs of the user of a medicament delivery device. The exemplary embodiments may adapt the basal ratio for the user based on historical medicament delivery data for the user. In addition, the exemplary embodiments may update the basal ratio based upon more recent trends that diverge from the historical medicament delivery data. The degree of adaptivity provided by the exemplary embodiments may be bound to not exceed an upper threshold and/or a lower threshold. The degree of adaptivity may be modulated by controlling the rate of adaptivity too small increments each time the basal ratio is updated.

According to some embodiments, an insulin management method implemented by an insulin delivery system is provided. The method includes determining an assumed insulin on board based on an assumed external dose calculated to correct an initial blood glucose value of the user to a target blood glucose. The method includes delivering insulin from an insulin delivery device with the insulin in the form of a plurality of correction bolus doses during a fasting period in response to received blood glucose measurements, the correction bolus doses compensated for by a determined insulin on board, wherein for at least a first correction bolus dose of the plurality of correction bolus doses the determined insulin on board equals the assumed insulin on board. Other systems, devices and methods are also provided.

An insulin management method implemented by an insulin delivery device is provided. The method includes detecting a starting activity associated with preparation of use of the insulin delivery device in the form of an automatic insulin delivery device attachable to a user's body for a duration of a fasting period within an overall time period. The method includes initiating automated delivery of insulin in the form correction bolus doses in response to periodically received blood glucose measurements during the fasting period. Other methods, devices and systems are also provided.

Disclosed herein are various embodiments comprising methods to propose or modify a basal profile of a user, wherein the basal profile is delivered by an automatic drug delivery system operating in manual mode or is administered manually by the user. Suggestions of initial basal profiles or modifications to existing basal profiles may be based on previous glucose control outcomes or previous insulin delivery as recorded by the automatic drug delivery system.

Disclosed are techniques, processes, systems, and programming code that enables users of automatic drug delivery devices to initiate the automatic drug delivery device for an initial use phase as well as implement changes that control the adjustment of target setpoints by a medication delivery algorithm used in the control of the automatic drug delivery device. During the initial use phase, the automatic drug delivery device may be based on the user's glucose control outcome without performing time consuming and frequent settings of sensor values as well as allowing users to remain substantially within range of any target setpoints. In addition, the disclosed techniques, processes, systems, and programming code enable users to have initial dosage settings automatically set without having to input what were previously considered fundamental inputs.

A computerized system for communicating treatment information to a user. The computerized system comprises a memory (22) storing data comprising least time-based user metabolite data and a processor (23). The processor (23) comprising a dose determination module (24) adapted to determine a possible drug dosage based on said data, a disturbance module (25) adapted to determine whether said data or the possible drug dosage triggers at least a disturbance threshold from a plurality of disturbance thresholds and a notification module (26) adapted to, when the disturbance module (25) determines that the at least one disturbance threshold is triggered or when at least a disturbance bypass is triggered, issue a user notification, the user notification being issued to the user and comprising the possible drug dosage. The plurality of disturbance thresholds comprising a bolus threshold, a drug threshold, and a time threshold.

The exemplary embodiments may detect the changed ambient air pressure and may adjust settings for the medicament delivery device to compensate for the changed ambient air pressure. The exemplary embodiments may detect the changed ambient air pressure and may adjust settings for the medicament delivery device to compensate for the changed ambient air pressure. Based on the detection of these events, the medicament delivery device may be switched into a flight mode. In the flight mode, medicament boluses may be reduced to nominal dosages, basal delivery rates may be modified and sample periods for sensors, like glucose monitors, may be shortened to sample sensor values more frequently. The exemplary embodiments may prohibit delivery of medicament during times of changing ambient air pressure to avoid over-delivering or under-delivering the medicament due to the ambient air pressure level.

An insulin patch control method and a device therefor are provided. An insulin patch control method and a device therefor are provided. The insulin patch control method according to one embodiment of the present invention comprises the steps of: obtaining, from an insulin patch, blood glucose information measured by a blood glucose sensor; inputting the obtained blood glucose information into a first neural network; estimating a pump parameter of the insulin patch on the basis of output data of the first neural network; and simulating the insulin patch by inputting the blood sugar information and the pump parameter into a second neural network.

A continuous glucose monitor (CGM)-driven basal insulin titration system and method for patients with Type 2 Diabetes can be adapted to the needs and concerns of subjects just starting on basal insulin therapy. The method uses as inputs historical CGM data, basal insulin dose information, reports of hypoglycemia, and past recommendations and generates an adjusted insulin dose along with a report advising whether to continue the titration process, or to stop. The method can generate a new recommendation on a regular basis (e.g., each day) until it determines an adequate, consistent dose size.