Devices, systems and methods for the broad-spectrum reduction of pro-inflammatory cytokines in blood. The pro-inflammatory cytokines can be freely circulating in the blood as well as cytokines that are transported within or bound to the surface of particles collectively referred to as CytoVesicles while simultaneously adsorbing toxins and pathogens from blood and blood plasma. A plasma separation column with binding, capture and adsorbent components optimize the removal of cytokines and CytoVesicles from blood while minimizing the removal of essential blood elements. Adsorbent components are incorporated within the extra-lumen space, outside of the plasma fiber walls and within the outer shell of the column and can include activated carbon, ion exchange resins and non-ionic exchange resins. The resulting devices, systems and methods alleviate the symptoms or severity of a wide range of disease conditions associated with an abnormal production or dysregulation of pro-inflammatory cytokines.

The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.

The present invention relates to a barrier membrane arrangement (10, 110) for a medical device for providing a substantially liquid tight seal between a piercing member and a barrier member (12) and a method for manufacturing such a barrier member arrangement. The present invention also relates to a method for connecting a first and a second medical device at the barrier member arrangement (10, 110). The barrier member arrangement (10, 110) comprises a first member (11), a second member (13) and a barrier member (12). The second member (13) can be interlocked to the first member (11) by means of a connection arrangement (18) at an optional stage by a user. After interlocking the second member (13) to the first member (11), the barrier member (12) has been compressed to provide for an increased leakage security. The barrier member arrangement (10, 110) also provides for a prolonged working life of the barrier member (12) and any medical device which comprises such a barrier member arrangement (10, 110).

Systems and methods for delivering a medical fluid are disclosed. The system includes a fluid flow path, a fluid administration device adapted to deliver the medical fluid through the fluid flow path, and a controller in communication with the fluid administration device. The method includes using the system to determine a desired flow rate of the medical fluid at a distal end of the fluid flow path based upon at least a desired flow profile of the medical fluid at the distal end. The method further includes initiating a fluid delivery operation by delivering the medical fluid through the fluid flow path according to fluid delivery parameters provided to the fluid administration device by the controller. Information about the fluid delivery operation may be received at the controller which executes a control function to adjust the fluid delivery parameters based on the received information.

The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.

The present invention relates to a barrier membrane arrangement (10, 110) for a medical device for providing a substantially liquid tight seal between a piercing member and a barrier member (12) and a method for manufacturing such a barrier member arrangement. The present invention also relates to a method for connecting a first and a second medical device at the barrier member arrangement (10, 110). The barrier member arrangement (10, 110) comprises a first member (11), a second member (13) and a barrier member (12). The second member (13) can be interlocked to the first member (11) by means of a connection arrangement (18) at an optional stage by a user. After interlocking the second member (13) to the first member (11), the barrier member (12) has been compressed to provide for an increased leakage security. The barrier member arrangement (10, 110) also provides for a prolonged working life of the barrier member (12) and any medical device which comprises such a barrier member arrangement (10, 110).

A device for administering liquids to an animal, in particular therapeutic agents, comprises a vessel (10; 50; 70; 100; 200) defining a collection chamber (11) therein. The following components are provided on the vessel: an inlet opening (13) for the therapeutic agent into the collection chamber, a first outlet duct (14) connected to a cannula element (3) which is prearranged so as to be introduced into the animal, the opening (14a) of the first outlet duct into the collection chamber being provided at a distance from a base (16) of the vessel, a second outlet duct (15) connected to a cannula element (3) which is prearranged so as to be introduced into the animal, the opening (15a) of the second outlet duct being provided substantially at the base of the vessel, and first shut-off means (17) for selectively shutting off the second outlet duct (15), the means being provided for preventing or allowing the flow from the collection chamber through the second outlet duct.

Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.

A disposable cassette (1) for storing and delivering a medical drug, the cassette (1) comprising a cartridge (7) containing the medical drug, a waste reservoir (8) arranged to receive waste liquid and/or gas, an injection needle (9) ranged to deliver the medical drug, and a valve block (10) being movable between a first position and a second position. The first position establishes a fluid passage between the cartridge (7) and the waste reservoir (8), while preventing fluid flow from the cartridge (7) to the injection needle (9), and the second position establishes a fluid passage between the cartridge (7) and the injection needle (9), while preventing fluid flow from the cartridge (7) to the waste reservoir (8). The cartridge (7), the waste reservoir (8), the valve block (10) and at least part of the injection needle (9) are arranged inside a cassette housing (2), and the valve block (10) is operable to be moved between the first position and the second position without a user operating the cassette (1) coming into direct contact with parts arranged inside the cassette housing (2).