A method of and composition for treating a patient having Mycobacterium avium complex (MAC), and in one embodiment Mycobacterium avium subspecies paratuberculosis (MAP), causing one or more diseases, an embodiment of the method including administering to the patient an effective amount of one or more antibiotics and administering to the patient an effective amount of ultraviolet blood irradtiation (UVBI) treatments, and an embodiment of the composition including an effective amount of one or more antibiotics and an effective amount of UVBI treated blood of the patient.

In one aspect, the present invention relates to a wound-care assembly The wound-care assembly includes a base layer. A film layer is operatively coupled to the base layer and a fluid conductor is in fluid communication with a wound and a vacuum source. The wound-care assembly further includes a fiber-optic patch comprising a plurality of fiber-optic strands. The fiber-optic strands are pressed into contact with an interior surface of the wound by the fluid conductor. The fiber-optic patch provides ultraviolet light to the wound and the relative vacuum is applied to the wound via the vacuum source and the fluid conductor.

A device comprising a housing having a handle end and a treatment end. The treatment end is configured to provide an antimicrobial treatment and a heat treatment. The treatment end comprises an applicator having an applicator surface for providing at least the heat treatment. The device includes a heat generation unit configured to heat the applicator surface in use, a source of antimicrobial agent, and a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit. The device can be a hand-held device and used to apply topical treatment to a treatment area of a subject.

A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

A light irradiation device includes: a flow channel through which blood or a blood component flows; and an LED lamp which irradiates the blood or the blood component flowing through the flow channel with light so as to inactivate a virus included in the blood or the blood component, in which a multilayer structure in which a plurality of the flow channels is arranged in parallel is formed.

A catheter connector includes an inner wall that defines an interior of the catheter connector and is transmissive to ultraviolet (UV) light. An outer wall defines an exterior of the catheter connector. One or a plurality of UV light sources is disposed between the inner wall and the outer wall or on the outer wall positioned to emit UV light into the interior of the catheter connector. A flow sensor is provided for sensing a flow of fluid in the interior of the catheter connector, and circuitry electrically connects the UV light sources, the flow sensor and a power source, such that electrical power is supplied to the UV light sources when a fluid flows through the interior of the catheter connector.

In one aspect, the present invention relates to a wound care system. The wound care system includes a power unit and a processor coupled to the power unit. An ultra-violet light-emitting diode array is electrically coupled to the processor. A thermoelectric element is thermally exposed to the ultra-violet light-emitting diode array. A probe is optically coupled to the ultra-violet light-emitting diode array. The thermoelectric element cools the ultra-violet light emitting diode array thereby optimizing the ultra-violet light emitting diode array.

A system for preparing a cancer vaccine (and optionally purifying the blood) has a blood filtration system, controlled by a processing unit, for filtering exogenous blood plasma to isolate tumor cells, tumor stem cells and tumor breakdown products. The blood filtration system filter includes multiple layers having differently sized apertures to retain differently sized materials (from among (i) tumor cells of different sizes, (ii) tumor stem cells and (iii) tumor DNA or other breakdown products. A device directs electromagnetic radiation at the isolated tumor cells, tumor stem cells and tumor DNA (or other breakdown products). The electromagnetic radiation may cause at least one of the (i) isolated tumor cells, (ii) isolated tumor stem cells, (iii) isolated tumor protein or breakdown products of the cells such as DNA to have a coagulated outer layer or a coagulated outer surface. The electromagnetic radiation may have a UV wavelength. A conical coil improves blood flow rate uniformity.

An apparatus can include a left cover, sized and shaped to fit over a left eye of a patient to define a left cavity between the left cover and an anterior surface of the left eye and a right cover, sized and shaped to fit over a right eye of the patient to define a right cavity between the right cover and an anterior surface of the right eye. The apparatus can include a left pressure source to apply a left working fluid to the left cavity, the left pressure source capable of generating a left cavity pressure including a left negative gauge pressure and a right pressure source to apply a right working fluid to the right cavity, the right pressure source capable of generating a right cavity pressure including a right negative gauge pressure, where the right pressure source can be separate from the left pressure source. The left pressure source can be configured to generate a left cavity pressure independently of the right pressure source and the right pressure source can be configured to generate a right cavity pressure independently of the left pressure source.

A device for photoexcitation of a photo-responsive material, such as a photochromic material, includes a pen-type housing having a UV lamp at one end and a visible light lamp at the other end. The device includes a microcontroller, a power supply, and an input device such as button, microphone, temperature sensor, or accelerometer. The beam width of the lamps can be adjusted by a lens adjacent to the respective lamps. The device is designed to photoexcite the photo-responsive material into various states depending on the type and wavelength of light emitted from the device. The device enables writing and erasing on a substrate, such as human skin, that contains or is embedded with the photo-responsive material, by exposing the material to light emitted from the device.