Devices for controlled administration of liquid solutions to nasal cavities and paranasal sinuses are disclosed. The proposed devices comprise an external housing defining an inner space and having a proximal and a distal end. The external housing comprises an air system for injecting air to a nostril plugs assembly; a pump system for pumping the liquid solution to the nasal cavities; a removable cartridge holding the liquid solution, connected to the pump system; and a nostril plugs system removably connected to the pump system. The nostril plugs system comprises a two-line resilient tube; a plug-in system connected to one of the resilient tube; and a nostril plugs assembly connected to the other end of the resilient tube. The proposed devices may be used for the treatment of respiratory diseases including the respiratory syndrome coronavirus 2 (SARS-CoV-2).

A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject. The delivery device includes a nosepiece unit for insertion into a nasal cavity of a subject and an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject. The delivery device also includes a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.

An apparatus (10) for controlling flow of fluid from a wound site of a patient including a cavity (28) connectable to a wound site and a reservoir (16). The cavity (28) may have a first deformed state, and a second state in which it is not deformed or less deformed than in the first state. The cavity (28) may be adapted to manage fluid flow between the wound site and the reservoir (16) during transition of the cavity (28) between the first state and the second state. An actuator element (64) of the apparatus (10) may be adapted to operate on the chamber (28) to transition the cavity (28) from the second state to the first state.

Disclosed herein are pharmaceutical compositions, devices, their combinations, and their uses thereof for example in treating or preventing headaches.

A intranasal device and method for self-administration of a medicament are provided. The intranasal device includes a body, a catheter, a feedback mechanism, and a delivery system. The body has a chamber configured to store the medicament. The body defines a channel that extends from an interior of the body to an exterior of the body. The catheter is configured to be actuated to extend from the body through the channel and is in fluid communication with the chamber. A distal end of the catheter is configured for entry into a nasal passage of a patient. The feedback mechanism is configured to indicate a position of the distal end of the catheter within the nasal passage. The delivery system is configured to deliver the medicament from the chamber into the nasal passage via the catheter.

Disclosed are various embodiments for an anti-reflux nasal aspirator that includes a nozzle comprising a nozzle outlet, a bulb configured to provide suction at the nozzle outlet in response to a squeezing force applied to the bulb, an anti-reflux coupler positioned between the bulb and the nozzle through which air passes from the bulb to the nozzle, and a one-way air valve positioned in an aperture located at a base of the bulb. The anti-reflux coupler may include a check valve configured to prevent reflux of debris into the bulb. The check valve may include one of an umbrella valve; a duckbill valve; a slit-cutting valve; and a flapper valve.

An apparatus (10) for controlling flow of fluid from a wound site of a patient may include a chamber (28) connectable to a wound site and a reservoir (16). The chamber (28) may have a first deformed state, and a second state in which it is not deformed or less deformed than in the first state. The chamber (28) may be adapted to manage fluid flow between the wound site and the reservoir (16) during transition of the chamber (28) between the first state and the second state. An actuator element (64) of the apparatus (10) may be adapted to operate on the chamber (28) to transition the chamber (28) from the second state to the first state.

A nozzled cartridge (20) for storing medicine, according to an aspect of the present application, includes a medicine container (21) that is to be filled with a predetermined quantity of a powdered medicine, a nozzle portion (22) that is formed on the medicine container (21) and that ejects the powdered medicine, a closing member (24) that closes an opening (22a) in the nozzle portion (22), and a valve member (25) that functions as a plug to close another opening (23a) in the medicine container (21), and that is opened when administering medicine. The nozzled cartridge (20) is detachably mountable to a sprayer (30) when administering medicine.

An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.