The present disclosure describes a system that automatically detects patient-ventilator asynchrony and trends in patient-ventilator asynchrony. The present disclosure describes a framework that uses pressure, flow, and volume waveforms to detect patient-ventilator asynchrony and the presence of secretions in the ventilator circuit.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated and deflated to position and stabilize the catheter in a cavity for delivery of a treatment. The catheter can include an extraction point associated with a lumen to remove fluids and material from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a liquid saline solution, a fluid medium, or a radioactive isotope provided to a corresponding lumen for delivery of the treatment.

Apparatus and associated methods relate to diagnostic device and system including a proximal balloon disposed along a length of a catheter and a distal balloon disposed at a distal end of the catheter, with at least one camera disposed at the distal balloon and a pH sensor deployable via inflation of the proximal balloon and configured to engage a patient's esophagus wall to attach the pH sensor to the patient's esophagus wall. In an illustrative example, the pH sensor may be releasably retained to the catheter adjacent to the proximal balloon. The pH sensor may include a tissue engaging feature configured to engage a patient's esophagus wall to attach the pH sensor to the patient's esophagus wall. The diagnostic device may improve upon existing processes by providing a single device to perform a multi-purpose diagnostic procedure.

A method and apparatus are disclosed for regulating a temperature of an esophagus when heat or cold is delivered to a left atrium, the method including altering a heat exchange device from an insertable configuration to a heat exchanging configuration which conforms and corresponds with a cross-section of an inside of the esophagus such that the esophagus is maintained in its natural shape and location. In some embodiments the heat exchange device has a heating/cooling balloon which is inflated to be in the heat exchanging configuration. Some alternative embodiments includes altering the configuration of the balloon to conform to or correspond with the cross section of an esophagus by means other than inflation.

Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.

A temporary esophagus occlusion device for providing temporary occlusion of the esophagus during intubation of a in patient includes a frame configured to transition between a contracted state, in which it can be swallowed by the patient, and an expanded state, wherein in the expanded state, the frame has a maximum outer diameter sufficient to span an inner diameter of the esophagus of the patient. The device also includes a flexible cover connected to and extending over at least a portion of the frame when the frame is in the expanded state to at least partially block flow of fluid and/or solid materials through the esophagus and a guidewire attached to the frame, sized to be swallowed by the patient along with the frame and having a proximal end portion configured to remain external to the patient's body and a distal end connected to the frame.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

Methods, systems, and devices are described for fabricating, providing, and using an orogastric tube. The orogastric tube may have, among other things: a proximal end section; a distal end section opposite the proximal end section and having a flexible, resilient curved portion; at least one sump channel extending from the proximal end section along a pre-determined length of the orogastric tube into the distal end section; at least one suction channel extending from the proximal end section along a pre-determined length of the orogastric tube into the distal end section; and optionally at least one balloon channel extending from the proximal end section along a pre-determined length of the orogastric tube to the distal end section. The optional balloon channel is in communication with an expandable balloon in the distal end section; and a main channel encloses a pre-determined length of the sump channel, the suction channel, and, if present, the balloon channel.