The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

Some implementations of the disclosure are directed to a balloon dilator system, including: a balloon pump hand piece configured to pump pressurized fluid through a flexible tube to inflate an inflatable balloon, the balloon pump hand piece comprising: an attachment mechanism for removably coupling the balloon pump hand piece to a proximal end of an endoscope; the flexible tube, wherein the flexible tube is configured to be in fluid communication with the balloon pump hand piece at a first end of the flexible tube, and the inflatable balloon at a second end of the flexible tube; a hollow inner cannula; and the inflatable balloon, wherein the inflatable balloon is external to and circumferentially attached to the hollow inner cannula between the proximal end of the hollow inner cannula and the distal end of the hollow inner cannula.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

Embodiments generally relate to a device for monitoring air pressure in the body of a patient. The device comprises a tube comprising a feeding lumen; a sensor lumen positioned parallel to the feeding lumen; at least one sensor positioned in the sensor lumen; and at least one perforation positioned to expose the at least one sensor to an air pressure within the body of a patient when the device is positioned at least partially in the airway of the patient. The at least one sensor is configured to generate data related to the pressure to which the sensor has been exposed.

An example catheter has an elongate member defining an elongate member proximal end, an elongate member distal end, an outer surface, and a main body, the outer surface defining a side opening at a position between the elongate member proximal end and the elongate member distal end, the main body defining a first lumen and a second lumen, the second lumen extending from the elongate member proximal end to the side opening; a balloon disposed on the elongate member between the side opening and the elongate member distal end; and an engagement member disposed in the second lumen, the engagement member defining an engagement member proximal end and an engagement member distal end, the engagement member proximal end extending axially beyond the elongate member proximal end, the engagement member distal end having an engagement portion and extending radially beyond the side opening in a first direction.

A method and apparatus are disclosed for preventing injury to an esophagus caused by heat or cold being delivered to the left atrium, the method including altering a heat exchange device from an insertable configuration to a heat exchanging configuration which has an inflated generally flattened cross section (e.g. capsule-shaped, elliptical) corresponding with the cross section of the inside of the esophagus such that the esophagus is maintained in its natural shape and location. In some embodiments the heat exchange device has a heat exchanger which is inflated to be in the heat exchanging configuration.

The present invention is directed to systems, devices and methods for trans-septally delivering carbon dioxide through a minimally invasive catheter to create a gaseous pocket or emphysema between the posterior wall of the left atrium and the esophagus during cardiac ablation of the left atrium. This pocket of gas expanded tissue serves to thermally insulate and separate the esophagus from the left atrium during ablation to prevent the formation of an atrial-esophageal fistula. The system comprises a control system to precisely deliver the gas to a desired location through a needle-based catheter assembly.

The present disclosure is directed to a method of determining a position of a medical instrument. The method may include inserting a first material into a body and adjacent to the medical instrument, analyzing at least one characteristic of the inserted first material, and determining the position of the medical instrument based on the analysis of the at least one characteristic.

A balloon catheter for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen; the ballon catheter comprising: An elongated balloon; a coating layer overlying an exterior surface of the balloon wherein the coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent; and a length-control mechanism (600) which stretches and elongates the balloon during deflation, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

A system comprising a handpiece and drive system configured to removably couple to a proximal end of a housing. A scalpet assembly is configured to removeably couple to the housing, and includes a scalpet array comprising at least one scalpet configured for rotation. The scalpet array is configured to harvest dermal plugs via fractional resection. A collection chamber is configured to collect the dermal plugs, and to house formation of an injectable filler by mincing the dermal plugs, and mixing the dermal plugs with a carrier. The injectable filler is configured for bulk fill. The collection chamber includes a loading port, and a cannular syringe is configured to mate with the loading port to receive the injectable filler, and to deliver the injectable filler for the bulk fill.