Provided are gastric residence dosage forms comprising flexible arms that can help prevent premature passage of the gastric residence system through the pylorus of a patient. In particular, described herein are gastric residence systems comprising one or more arms extending radially, the one or more arms comprising a first segment comprising a first polymer composition and a second segment comprising a second polymer composition, wherein the first segment has a stiffness of greater than a stiffness of the second segment, as measured using a 3-point bending test per ASTM D790. The second segments of the arms of the gastric residence systems help prevent premature passage of the gastric residence system through the pylorus of a patient.

The present invention provides an automatic drug delivery device. The automatic drug delivery device includes an enclosure and a first piston disposed in the enclosure. The first piston partitions the enclosure to a first drug delivery chamber and a first expansion chamber. A first through hole and a second through hole are formed in the wall of the enclosure, the first through-hole communicates with the first drug delivery chamber, and the second through-hole communicates with the first expansion chamber. A first targeted dissolution membrane covers the first through hole and the second through hole, and dissolves at a first targeted region. A drug is filled in the first drug delivery chamber, and an expandable material is included in the first expansion chamber. The expandable material in the first expansion chamber can expand after absorbing liquid.

The present disclosure provides a gastroretentive drug delivery device having an expandable structure. The drug delivery device includes: a capsule body; an arm moving part movable within the capsule body; an elastic body positioned between one end of the capsule body and the arm moving part and acting to move the arm moving part toward the other end of the capsule body; an arm support part movable within the capsule body; a capsule cap configured to engage the other end of the capsule body; a rail formed within the capsule body; and an arm configured to be unfolded by longitudinal movement of the arm moving part and move along the rail. A disintegrable immediate-release formulation is positioned between the arm moving part and the arm support part. A disintegrable sustained-release formulation is positioned between the arm support part and the capsule cap.

A nasogastric tube connector device includes an annular connector body for detachably engaging a through hole of a respirator mask having an inner peripheral surface defining a space, and a fixed member having a first concave surface and two side surfaces cooperating with the inner peripheral surface to define an opening of the space for passing of a nasogastric tube therethrough. A first plug member is detachably inserted through the opening into the space, and includes a second concave surface cooperating with the first concave surface to define a main tube hole communicating with the space. A second plug member is detachably inserted into the main tube hole to sealingly close the opening.

A nasogastric tube connector device includes an annular connector body for detachably engaging a through hole of a respirator mask having an inner peripheral surface defining a space, and a fixed member having a first concave surface and two side surfaces cooperating with the inner peripheral surface to define an opening of the space for passing of a nasogastric tube therethrough. A first plug member is detachably inserted through the opening into the space, and includes a second concave surface cooperating with the first concave surface to define a main tube hole communicating with the space. A second plug member is detachably inserted into the main tube hole to sealingly close the opening.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

This disclosure includes intraluminal tubes comprising: an elongated tube (e.g., having a proximal portion, a distal portion configured to be disposed inside of an internal cavity of a patient, and a sidewall defining a lumen extending from the proximal portion to the distal portion, the distal portion defining one or more openings in fluid communication with the lumen) and a plurality of deployable tines, each coupled to the tube and disposed outside the sidewall of the distal portion, where each tine is movable from a collapsed state to a deployed state in which a portion of the tine extends laterally away from the distal portion of the tube. In some of the present intraluminal tubes, the sidewall of the distal portion defines a plurality of longitudinal grooves, and each tine is disposed in a different one of the grooves when the tines are in the collapsed state.

A system for feeding and evacuation has a feeding tube in place into a subject's stomach cavity, having a Luer-Lock compatible female connector on an outboard end, a feed source, a unique Lopez valve having a conventional connector on one end and a male Luer-Lock connector on the other end in place of the conventional tapered connector, a suction tube coupled to a suction source, the suction tube having a connector compatible with the conventional connector of the conventional Lopez valve on an end away from the suction source. With the feeding tube connected to the feed source, nutrients are supplied to the subject through the feeding tube, and with the feed source disconnected, the body of the unique Lopez valve connected to the feed tube by the male Luer-Lock extension and to the suction tube, the subject's stomach cavity is exposed to suction controlled by the conventional Lopez valve.

A securement device for a system for securing a nasal tube is provided. The securement device includes a bridle having a body extending between a first end and a second end. The body has a lobed or star shape. The securement device further includes a magnetic connection portion disposed at the first end of the bridle. A system for securing a nasal tube can include a securement device as described above, and a retrieval probe. The retrieval probe can include a catheter extending between a proximal end and a distal end; and a magnetic tip disposed at the proximal end. The magnetic connection portion of the bridle and the magnetic tip of the retrieval probe can be configured to magnetically couple during a procedure for inserting the bridle in a nasal passageway of a patient.