Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

Provided herein are gastroretentive dosage forms (GRDFs) for extended retention in a human stomach, comprising a body comprising at least two arms, the body configured to transform between a collapsed configuration for ingestion, an expanded configuration for retention within the stomach and a disassembled configuration wherein after a predetermined time period has elapsed, the GRDF disassembles into at least two parts such that each of the disassembled parts of the GRDF is sized for exiting the stomach; and, an erodible insert comprising a therapeutic agent, a diagnostic agent, an electronical device, or a combination thereof.

Disclosed is a two-way vacuum assisted closure system in the medical field which eliminates leakages based on the upper gastrointestinal system organs such as the stomach and intestine after stab wounds and/or wounds after surgical operations.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

The present disclosure provides a gastroretentive drug delivery device having an expandable structure. The drug delivery device includes: a capsule body having a space formed therein; an arm mounted at one end of the capsule body, the arm comprising a first hinge part, a second hinge part, a third hinge part and an elastic support part which enable unfolding and folding, wherein the first hinge part engages the elastic support part, the second hinge part engages a wing of the arm and is connected rotatably to the first hinge part, the third hinge part is positioned at one end of the wing and is connected rotatably to the second hinge part, a sustained-release supporter is positioned to face the third hinge part, an immediate-release formulation is positioned to face the elastic support part, and a sustained-release formulation is positioned between the sustained-release supporter and the immediate-release formulation; an elastic body acting to move the elastic support part in a direction toward the one end of the capsule body within the capsule body; and a capsule cap configured to engage the other end of the capsule body.

A system for feeding and evacuation has a feeding tube in place into a subject's stomach cavity, having a Luer-Lock compatible female connector on an outboard end, a feed source, a unique Lopez valve having a conventional connector on one end and a male Luer-Lock connector on the other end in place of the conventional tapered connector, a suction tube coupled to a suction source, the suction tube having a connector compatible with the conventional connector of the conventional Lopez valve on an end away from the suction source. With the feeding tube connected to the feed source, nutrients are supplied to the subject through the feeding tube, and with the feed source disconnected, the body of the unique Lopez valve connected to the feed tube by the male Luer-Lock extension and to the suction tube, the subject's stomach cavity is exposed to suction controlled by the conventional Lopez valve.

A handheld therapeutic apparatus and method of treatment are disclosed. In one example, the apparatus includes a valve system, a detachable gas cartridge housing unit that houses a gas cartridge or gas delivery from an outside gas cylinder in fluid communication with said valve system, a detachable treatment receptacle for the delivery of gas therapies is in fluid communication with said valve system, and a detachable nozzle in fluid communication with said valve system.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

There is provided with a method. A cardia and a pylorus of a stomach of a patient is blocked. The stomach is inflated. The stomach is secured within an abdominal cavity of the patient.

A ventilator mask and a joint thereof are provided. The ventilator mask includes a ventilator mask body and the joint. The joint includes a joint body, an upper cover, and a perforated cover. The joint body includes a first end portion, a second end portion, and a third end portion. The first end portion is configured to be movably connected to the ventilator mask body. The third end portion is configured to communicate with an oxygen source. An opening is disposed between the first and second end portions. The upper cover is pivotally connected to the joint body for closing or opening the opening. The perforated cover is disposed on the second end portion. The perforated cover has a through hole for insertion of a tube. The ventilator mask can be airtightly fitted to the patient’s face. There is no need to remove the ventilator mask for performing sputum suction.