System for percutaneous drainage of a drainage site includes a catheter, a drain tube, a first pump, a flush tube, a second pump, and a controller. The catheter includes a drain lumen defined by a first portion of a catheter wall and a septum, and a flush lumen defined by a second portion of the catheter wall and the septum. The flush lumen is separated from the drain lumen by the septum. The septum has at least one septal hole disposed therein such that the drain lumen and the flush lumen are in communication via the at least one septal hole. The catheter wall has at least one wall hole disposed therein such that the drain lumen is in communication with the drainage site when the distal end portion of the catheter is placed within the drainage site.

Disclosed are embodiments of an apparatus, system, and method for performing a sleeve gastrectomy. The apparatus can include a bougie for insertion into an interior of a stomach, the bougie having a proximal bougie end and a distal bougie end, an inflation lumen having a proximal lumen end and a distal lumen end, the inflation lumen extending from the proximal bougie end through the distal bougie end, a fluid delivery system coupled with the proximal lumen end, the fluid delivery system being operably configured to deliver positive pressure in a predetermined positive pressure range into the stomach, and a monitor coupled with the proximal lumen end operably configured for the monitoring of pressure or volume within the stomach. The bougie can be operably configured to define a resection line for the sleeve gastrectomy when the predetermined positive pressure range is achieved within the stomach.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

The invention relates to an implantable device suitable for being fixed in a fixation position to a wall of a patient's stomach, the implantable device being accommodated in the stomach when the implantable device is in the fixation position, the implantable device being characterised in that it comprises a reserve of an active substance and an injector suitable for administering the active substance to the patient.

A medical delivery device suitable for insertion into a lumen of a patient, the medical device (100, 200) comprising a capsule (110, 120, 210, 220) sized to be inserted into the lumen, the capsule comprising a base member, and an actuation mechanism comprising an actuation member (150, 250, 350) configured for movement relative to the base member along an axis, and an energy source (140, 240, 340) associated with the actuation member for powering the actuation member to move relative to the base member along the axis. The base member and the actuation member define a latch assembly comprising: a) a dissolvable firing member (160, 260, 360), the dissolvable firing member being at least partially dissolvable when subjected to a biological fluid, b) a retainer portion (113, 213, 313) comprised by one of the base member and the actuation member, and c) a movable latch (152, 252, 352) configured for lateral movement relative to the axis, the movable latch defining a first surface with a blocking portion (153, 253, 353), and a second surface (152a, 252a, 352a) configured for interacting with the dissolvable firing member (160, 260, 360). In a pre-firing configuration, the blocking portion (153, 253, 353) of the movable latch engages the retainer portion (113, 213, 313) in a latching engagement, and the second surface (152a, 252a, 352a) of the movable latch interacts with the dissolvable firing member to restrict lateral movement of the movable latch thereby preventing release of the latching engagement. In a firing configuration where the dissolvable firing member (160, 260) has become at least partially dissolved, the movable latch is allowed to move laterally thereby releasing the latching engagement.

The present invention relates to an adapter for non-invasive mechanical ventilation probes with an inhalation port and orifice occluder. Specifically, the invention comprises a probe adapter with an inhalation port and orifice occluder, coupled to the oronasal mask disposed on a user or patient. According to the present invention, the probe adapter also receives a metered dose inhaler that further receives an anesthetic circuit with two enteral probes, a left enteral probe and a right enteral probe. The technical field of the invention belongs to the field of medical devices for respiratory therapy, for use in patients with assisted non-invasive mechanical ventilation and concomitant use of enteral probes with the requirement of metered dosage inhaled medicinal products.

The present invention relates to an adapter for non-invasive mechanical ventilation probes with an inhalation port and orifice occluder. Specifically, the invention comprises a probe adapter with an inhalation port and orifice occluder, coupled to the oronasal mask disposed on a user or patient. According to the present invention, the probe adapter also receives a metered dose inhaler that further receives an anesthetic circuit with two enteral probes, a left enteral probe and a right enteral probe. The technical field of the invention belongs to the field of medical devices for respiratory therapy, for use in patients with assisted non-invasive mechanical ventilation and concomitant use of enteral probes with the requirement of metered dosage inhaled medicinal products.

Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

Provided is a liquid drug permeation system (100) for causing permeation of a liquid drug under an endoscope (10), including: a liquid drug permeation apparatus (20); and an assisting device (30) configured to assist position adjustment of the liquid drug permeation apparatus (20) under the endoscope (10). When a connector portion (32) of the assisting device (30) is mounted on the endoscope (10) and an inner tube (21) is fixed to the assisting device (30) with a fixture (33), an outer tube (22) of the liquid drug permeation apparatus (20) is allowed to selectively advance and retract with respect to the inner tube (21), and a water-absorbing material (23) mounted on a distal end of the inner tube (21) is allowed to be pulled into the outer tube (22) by advancing the outer tube (22) with respect the inner tube (21).