Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

A drug delivery device for conducting a medical therapy includes a housing with an exit port opening, and an exit port assembly, where said exit port assembly includes a rigid exit port sealing holder and a soft exit port sealing, and provides both a fluid-tight closure of the exit port opening and a fluid-tight connection between the housing and the rigid exit port sealing holder.

The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

Apparatuses, devices, and methods for performing endoscopic tissue resectioning in the gastrointestinal tract are disclosed. In some embodiments, a tissue resectioning device may include first and second scaffolds each arranged in a tubular configuration. The tissue resectioning device may further include a hook tool engageable with the first scaffold and/or the second scaffold to bias the scaffolds to engage a target section of tissue between the first scaffold and the second scaffold. The hook tool may also engage the section of tissue to pull the section of tissue into the path of a cutting edge of each of the first and second scaffolds. In some embodiments, the tissue resectioning device is provided over a scope, which extends within a lumen of an overtube.

The present invention is a system and method for water cycling colonoscopy that includes a colonoscope with a water ejection system and a camera, and a rectal overtube that receives the colonoscope therein. The overtube is placed in the anus and has a vacuum port outside the anus that attaches to a vacuum source. The overtube vacuum port vacuums water emitted by the colonoscope while the colonoscope is moving through the colonic lumen to control the amount of fluid in the colonic lumen. The overtube may be fitted with structures to improve the fit and attachment to the anus, including an inflatable cuff and a flexible skirt.

The present disclosure provides with a device (100) for temporary residence at an ileocecal valve of a subject, the device carrying a load of an active pharmaceutical ingredient (API) and having an expanded configuration. When the device is positioned at the ileocecal valve and in the expanded configuration, the device is configured to be retained at the ileocecal valve of the subject, and for releasing at least partially the active pharmaceutical ingredient while allowing chyme flow. The device is further configured to transfer from the expanded configuration into an emptying configuration in which the device is configured to pass through the ileocecal valve. This enables dispensing locally therapeutic substances at an ileocecal valve (ICV) region of a human body.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

An anesthetized catheter that includes the ability to administer substances and remove substances via the catheter orifice as well as pericatheter with the option of using wireless technology, while also having an indication system.

A medical drainage stent that includes a stent body, and a proximal portion and a distal portion that are located at two ends of the stent body for connecting a first tissue wall and a second tissue wall in a juxtaposing manner. The stent body is fixed between the first tissue wall and the second tissue wall to provide a drainage channel. The proximal portion of the stent has N extension portions, where a fixed end of the extension portion is fixedly connected with an edge of a proximal end of the stent body, and the other end of the extension portion is a free end in a free state. Structures of the N extension portions at least partially protrude from the stent body in a radial direction, so that the proximal portion of the stent is fixed on the first tissue wall, where N is a positive integer.

Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.