The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.

A drug delivery system is provided that has an adjustable dose mechanism allowing setting and locking the dose then administration of the set dose. A method for administering a medicament using the drug delivery system is also provided.

Certain embodiments of a medicinal applicator can comprise a base, a medicinal cream receiving port in the base, and a shaft extending along a conceptual shaft axis from the base and terminating at an applicator tip. There is at least one exit aperture located along a portion of the shaft. An unobstructed pathway is in communication with the receiving port and the exit aperture. A stop plate that extends essentially radially from the base delineating the base from the shaft. The shaft possesses a shaft outer shape defined by a shaped leading and trailing edge defining a narrow diameter proximal zone that extends along the shaft from the stop plate to a gradually increasing diameter transition zone that extends to a large diameter paddle zone, which terminates into a shaft distal end.

A device for the treatment of anal fistula-in-ano and complex fistula-in-ano is disclosed. The device comprises: a balloon inflation/deflation tube (1); a suction/drainage tube (3); a scooping tube (2) that is disposed between the balloon inflation/deflation tube (1) and the suction/drainage tube (3); a diaphragm (4) that is disposed across the balloon inflation/deflation tube (1) and the suction/drainage tube (3); and an irrigation/drainage path (5) that is disposed between a balloon (6) and a plurality of spikes (7), said balloon (6) being disposed at an end of the of the balloon inflation/deflation tube (1), and said plurality of spikes (7) being disposed on an outer surface of both the balloon inflation/deflation tube (1) and the suction/drainage tube (3). The disclosed device: prevents premature closure of fistula wound, thereby minimizing the chances of recurrence; is easy to use, thus avoiding the need for a skilled medical practitioner; causes minimal pain; and is less time consuming.

A personal hygiene device comprises a tubular body constructed of a substantially watertight flexible material. The tubular body defines a cavity. An opening in the tubular body provides access to the cavity, which opening is selectively closable to create a watertight seal. A spray member, having a first end and a second end, is operatively connected to the tubular body at the first end. A channel in the spray member extends from the first end to the second end. The channel is exposed to the cavity at the first end. The second end of the spray member has openings that are exposed to the channel. Material in the cavity can travel from the cavity through the channel in the spray member, and exit through the openings in its second end. An adjusting means is selectively operable to control the amount of material that flows into the channel.

An anal irrigation system and a method for maintenance of an anal irrigation system comprising a tube assembly is disclosed, the method comprising a container and a tube assembly, the method comprising: providing instructions instructing a user to arrange a distal end of the tube assembly in the container for forming a liquid path and to fill liquid into the container; detecting liquid in the container; initiating a disinfection procedure, the disinfection procedure comprises; circulating the liquid in the liquid path for one or more cycles, the one or more cycles comprise one or more liquid circulations; providing instructions instructing the user to discharge liquid from the liquid path.

The present invention relates to a self-retaining enema nozzle (1,1′,1″,1′″) and an enema system (34) comprising said enema nozzle. The enema nozzle (1,1′,1″,1′″) comprises a catheter (2) provided with a retention member (3) arranged for being placed in a compact form during insertion in a body cavity and for being placed in an expanded form for retaining the enema nozzle in said body cavity, and wherein the enema nozzle (1,1′,1″,1′″) further comprises a restriction unit (4) arranged for placing the retention member (3) in its compact form. Since the restriction unit (4) holds, e.g. keeps, places and/or maintains the retention member (3) in the compact form both before and during insertion, any discomfort and/or harm that may be experienced using the conventional enema nozzles/devices is effectively prevented.

A negative pressure treatment arrangement comprising a multi-layered drainage film, wherein a drainage space is formed between two layers of the drainage film, a first film layer on the wound side delimiting the drainage space comprising a first opening arrangement facilitating the admission of fluids or gases to the drainage space and a second film layer facing away from the wound that also delimits the drainage space comprising a second opening arrangement designed to discharge fluids and/or gases from the drainage space, and also comprising a fluid-tight fixing film that can be used to fix the drainage film to the skin surrounding a wound and to cover at least one area of the second opening arrangement.

The present invention relates to a pharmaceutical dosage form for application to a mucous membrane, in particular to a buccal, intestinal, rectal or vaginal mucous membrane, comprising at least one string-like or strip-like preparation comprising the active pharmaceutical ingredient, the dosage from being configured to be wettable during a step of administration to a patient. The invention also relates to a method of producing the pharmaceutical dosage form.