A multi-type combination electrical stimulation method is for medical treatment of surface and internal infected tissues, surface wounds and ulcers, trauma injuries, abnormal plasia and fibrotic changes, and pain conditions. The multi-type electrotherapy system for non-invasive treatment of both surface and deep body bacterial and viral infections and wound healing includes a machine learning function optimization task algorithm, and a stimulation device electronically with the ability to generate carrier base waveforms with amplitude modulation of these waveforms by secondary frequencies. The ranges of such frequencies are base frequencies in the range of 1-20,000 Hz and modulating frequencies in the range of 1-200 Hz. The waveforms are generated by either direct digital synthesis (DDS) or digital to analogue (DAC) converter electronics.

A device for treating human keratinous material, in particular with the aid of an electric current. The device includes a reservoir containing a composition, in particular cosmetic or dermatological, to be applied to the keratinous material, and an end fitting for the application of the composition contained in the reservoir, the end fitting comprising a plurality of application members and a distributor. The distributor includes at least one storage cavity for the composition and supply orifices to conduct the composition from the storage cavity or cavities to the application members, and the distributor being configured so that the flow rate of the composition arriving at the application members is identical to within 20% for at least two application members, better for each application member.

An iontophoresis administration device includes: a power source, used to generate the pulsed direct current required to cause a medicinal agent to permeate an administration region of an organism, wherein the power source generates a forward pulsed direct current during a first time period and a reverse pulses direct current during a second period of time; a dielectric layer, configured to be in contact with the administration region, wherein the dielectric layer includes or has attached thereto an active agent that is to permeate the administration region via a pulsed direct current; and at least two electrodes, used to receive the pulsed direct current outputted by the power source, facilitating the provision of the received pulsed direct current to the dielectric layer. The iontophoresis administration device provided by the present disclosure not only increases the skin permeation rate, but is also not likely to irritate or harm the skin.

An iontophoresis administration device includes: a power source, used to generate the pulsed direct current required to cause a medicinal agent to permeate an administration region of an organism, wherein the power source generates a forward pulsed direct current during a first time period and a reverse pulses direct current during a second period of time; a dielectric layer, configured to be in contact with the administration region, wherein the dielectric layer includes or has attached thereto an active agent that is to permeate the administration region via a pulsed direct current; and at least two electrodes, used to receive the pulsed direct current outputted by the power source, facilitating the provision of the received pulsed direct current to the dielectric layer. The iontophoresis administration device provided by the present disclosure not only increases the skin permeation rate, but is also not likely to irritate or harm the skin.

A system and method for controlling microbial growth on and in medical devices and implants, especially biofilm infections, involves using pulsed electric fields (PEF). To eradicate at least a portion of a biofilm on a medical implant, for example, 1500 volts can be applied through an electrode system, with pulse duration of 50 μs and pulse delivery frequency of 2 Hz. In the clinical setting, systemic microbial therapy can be combined with PEF to achieve a synergistic effect leading to improved eradication of infections.

A iontophoresis method (700) is described for delivering vitamin C through the skin of a biological subject, the method comprising applying (702) a selected current profile, either continuous direct current or pulsed current or a combination of both to a biological subject. A iontophoresis composition is further described, comprising one or more of vitamin C, vitamin C derivatives, ions of vitamin C and ions of vitamin C derivatives and further comprising a silicon material and water. A iontophoresis kit for carrying out the iontophoresis method is also disclosed. The application further describes a iontophoresis device comprising an electrode assembly and circuitry configured to concurrently generate a continuous direct current stimulus and a pulsed current stimulus; a corresponding iontophoresis method for delivering a cosmetic composition to a biological subject is also disclosed.

A iontophoresis method (700) is described for delivering vitamin C through the skin of a biological subject, the method comprising applying (702) a selected current profile, either continuous direct current or pulsed current or a combination of both to a biological subject. A iontophoresis composition is further described, comprising one or more of vitamin C, vitamin C derivatives, ions of vitamin C and ions of vitamin C derivatives and further comprising a silicon material and water. A iontophoresis kit for carrying out the iontophoresis method is also disclosed. The application further describes a iontophoresis device comprising an electrode assembly and circuitry configured to concurrently generate a continuous direct current stimulus and a pulsed current stimulus; a corresponding iontophoresis method for delivering a cosmetic composition to a biological subject is also disclosed.

The present invention relates to a nerve suture patch having a self-healing property, and a production method thereof, and more specifically, to a self-healing nerve suture patch containing a self-healing polymer and a hydrogel, and a production method thereof. The nerve suture patch may be rapidly attached to epineurium by the adhesiveness of the hydrogel and easily suture a damaged nerve.

A method is provided for treating an intervertebral disc of a subject, the method including implanting at least one intra-pulposus exposed electrode surface in a nucleus pulposus of the intervertebral disc, and implanting one or more extra-pulposus exposed electrode surfaces outside the nucleus pulposus, in electrical communication with the intervertebral disc. Control circuitry, while electrically coupled to the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces, is activated to drive fluid and introduce nutritional substances into the intervertebral disc, by applying a voltage between the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces. Other embodiments are also described.

A reverse electrodialysis device using a precipitation reaction, according to one embodiment of the present invention, comprises a first cell stack alternately forming solid salt chambers and precipitation chambers through cation-exchange membranes and anion-exchange membranes which are alternately provided, and a first water-soluble solid salt and a second water-soluble solid salt which are filled in the solid salt chambers, wherein the first water-soluble solid salt and the second water-soluble solid salt are alternately filled in the solid salt chambers, and can react with each other so as to generate a precipitate in neighboring precipitation chambers when water is supplied.