An ingestible medical device that includes an ingestible capsule. Within the ingestible capsule is a non-refillable drug dispenser containing a therapeutic agent. The capsule can also include a real-time clock. A controller within the capsule can be operatively connected to the drug dispenser and can include a memory module and a processor operable to execute a software application stored on the memory module to control the operation of the drug dispenser to administer the therapeutic agent according to a real-time schedule measured via the real-time clock. The ingestible medical device can also include an iontophoretic circuit or system for drug delivery as well as physiological sensors to detect the occurrence or worsening of a medical condition.

A skin treatment device includes a control unit and a hand tool. The hand tool includes a body, a wiper head, and a needle roller head. The wiper head includes a rotatable wiper structure including one or more wiper blades. The needle roller head includes needle roller structure. The skin treatment device provides a multi-step process including desincrustation, skin transdermal delivery of topical agents, serums, and the like, microdermabrasion, and fractional micro-channeling application.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

A method is provided for treating an intervertebral disc of a subject, the method including implanting at least one intra-pulposus exposed electrode surface in a nucleus pulposus of the intervertebral disc, and implanting one or more extra-pulposus exposed electrode surfaces outside the nucleus pulposus, in electrical communication with the intervertebral disc. Control circuitry, while electrically coupled to the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces, is activated to drive fluid and introduce nutritional substances into the intervertebral disc, by applying a voltage between the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces. Other embodiments are also described.

Discussed is a hair care appliance including: a first care body having a first care electrode; a second care body having a second care electrode; and a bending unit connected between the first care body and the second care body. The first care body includes a main substrate electrically connected to the first care electrode, and a processor provided at the main substrate, and the second care body includes a battery electrically connected to the second care electrode, and the bending unit includes an elastic housing and a flexible substrate which is accommodated in the elastic housing and which electrically connects the battery to the main substrate.

A wound treatment device includes a flexible substrate having a top side, a bottom side and an opening extending therebetween. A reservoir has a port in fluid communication with the opening, and an iontophoretic driver circuit is electrically coupled to a plurality of electrodes.

Disclosed is a dental bleaching gel composition with high electric conductivity. It was the object of the present invention to provide a bleaching gel composition that is less initiating than prior art gels, and is highly efficient such that it can bleach within shorter time. The composition includes a peroxide, or a peroxide releasing compound such as carbamide peroxide, sodium perborate, or sodium percarbonate as a bleaching agent, a cross-linked polyacrylate polymer as a thickening component, and electrical conductivity enhancing ingredients such as electrolytes.

A method is provided for treating an intervertebral disc of a subject, the method including implanting at least one intra-pulposus exposed electrode surface in a nucleus pulposus of the intervertebral disc, and implanting one or more extra-pulposus exposed electrode surfaces outside the nucleus pulposus, in electrical communication with the intervertebral disc. Control circuitry, while electrically coupled to the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces, is activated to drive fluid and introduce nutritional substances into the intervertebral disc, by applying a voltage between the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces. Other embodiments are also described.

Apparatus is provided for treating an intervertebral disc of a subject, the apparatus including: at least one intra-pulposus exposed electrode surface, which is configured to be implanted in a nucleus pulposus of the intervertebral disc; and one or more extra-pulposus exposed electrode surfaces, which are configured to be implanted outside the nucleus pulposus, in electrical communication with the intervertebral disc. Control circuitry is electrically coupled to the at least one intra-pulposus exposed electrode surface and one or more extra-pulposus exposed electrode surfaces. The control circuitry is configured to drive fluid and introduce nutritional substances into the intervertebral disc, by applying a voltage between the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces. Other embodiments are also described.

Disclosed is an iontophoresis-based patch type medicine absorption device for allowing a medicine for medical treatment or a functional substance for skin care to be effectively absorbed into a user's skin by causing iontophoresis on the user's skin through a conductive patch. The iontophoresis-based patch type medicine absorption device for allowing the medicine for medical treatment or the functional substance for the skin care to be absorbed into the user's skin by the iontophoresis includes a medicine absorption device body that generates power to cause the iontophoresis. The medicine absorption device body includes a power circuit that is provided in an interior space of a body and that includes a power unit that generates the power for the iontophoresis and one or more electrodes to which the power is applied, and a bridge that is provided so as to be combinable with the body and that receives the power through the one or more electrodes. The bridge includes a bridge body provided so as to be combinable with the body and a plurality of bridge legs arranged along a circumferential direction of the bridge body and formed of a conductive material.