The present invention relates to a device for applying a cosmetic composition (P), comprising: —a capsule (1) that delimits a housing (10), —an application member (6) positioned in the housing (10) and impregnated with a cosmetic composition (P), —an electric exciter (29) comprising at least two electrodes (4, 5) in contact with the application member (6) and making it possible to circulate an electric current between these two electrodes (4, 5).

A switch-operated therapeutic agent delivery device. Embodiments of the operated therapeutic agent delivery device my include a switch that can be operated by a user, a device controller connected to the switch through a switch input where the device can actuate the device when certain predetermined conditions are met, following performance of both a digital switch validation test and an analog switch validation test. The switch operated therapeutic agent delivery device may have two parts, which are assembled by a user prior to use. These devices may be configured to determine if a current is present between the anode and cathode when drug is not intended to be delivered by the device. These devices may indirectly control and/or monitor the applied current without directly measuring from the cathode of the patient terminal.

A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.

The invention concerns an electrostimulation and/or iontophoresis device comprising a patch (10) suitable for application to a user's skin (12) and a voltage generator (22) suitable for applying a low intensity current through the user's skin by a system of electrodes located in said patch; This device is characterized in that it comprises a self-regulator (16) that varies the voltage supplied by the voltage generator as a function of the continuous measurement of the resistivity of the user's skin beneath said patch The resistance value of the skin provided by an element for measuring the resistance of the skin (24) yields the resistivity measurement.

The present invention involves devices and therapies for ocular diseases or disorders in individuals. Provided herein are therapeutic agents, and devices and methods of delivering therapeutic agents (e.g., nucleic acid vectors) to target ocular cells (e.g., retinal cells) involving methods of administering therapeutic agents to the individual and methods of electrotransfer of therapeutic agents.

A medical semiconductor is used to improve musculoskeletal pain by bringing a divalent metal (magnesium alloy) oxide film semiconductor into contact with the skin.

An integrated package comprising a lab-on-chip (LOC) is disclosed. The LOC includes at least one integrated device having a membrane portion having a membrane opening; the membrane portion having a first side and a second side, the first side opposite the second side, a MEMS portion disposed on the first side of the membrane portion, the MEMS portion having a sharp member disposed on an actuator stage within a MEMS cavity, and a fluidic portion disposed on the second side of the membrane portion, the fluidic portion having a fluidic cavity for flowing a fluid medium within the fluidic portion; and a fluidic cap forming a surface of the fluidic portion of the LOC, the fluidic cap having a fluidic inlet and a fluidic outlet. The method of operating the LOC includes power to the at least one integrated device to capture one or more particles for interrogation.

The present disclosure provides a spinal cord stimulation (SCS) system. The system includes at least one SCS lead including a lead body, at least one distal electrode located at a distal end of the lead body, the at least one distal electrode configured to apply electrical stimulation to a stimulation target of a patient, and a pain reduction assembly coupled to the lead body and configured to reduce post-operation pain at an incision site associated with implantation of the at least one SCS lead. The system further includes a pulse generator coupled to the at least one SCS lead and configured to control electrical stimulation delivered to the patient via the at least one SCS lead.

Disclosed herein is a cleaning system (30) for a dental implant part (2) that has been introduced into the jaw bone of a patient. For this purpose, in an advantageous embodiment of the invention, a securing element, which is adapted on the end side to connect to a corresponding connection element in the dental implant part, particularly preferably which can be screwed into a thread of the dental implant part by the end side, and to which a distribution element for a cleaning fluid as well as an electrical contact element can be attached, which distribution element can be connected to an external media reservoir via a media channel, and via which electrical contact element, a power source that is connectable to an external power source can be electrically connected to the dental implant part.

Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.