The disclosure relates to a flexible active species generator comprising: a first electrode of a conductive metal thin film; a second electrode of a ground electrode; a flexible dielectric layer of an insulator formed between the first electrode and the second electrode; and a plasma resistant functional layer formed between the dielectric layer and the second electrode, wherein the first electrode and the second electrode are electrically connected to an external power supply to generate an atmospheric pressure plasma to generate active species. The flexible active species generator has a plasma resistant function to prevent deformation and decomposition of an insulator caused by the plasma as well as an active species generating function from atmospheric pressure plasma, and has durability and safety, which is thus applicable to articles, foods, garments and human body in various forms.

Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

It is provided a method and devices for detecting kidney failure and dialysis of a subject wherein the epidermis is irreversibly electroporated without generating any heat and a negative pressure is applied forming micro-conduits in the epidermis from which the interstitial fluid can be extracted, analysed and filtered to produce for example a dialysate and returned to the subject.

A multi-functional portable skin care device comprises: a roller unit including a first roller and a second roller and an insulating ring member; a connecting unit including a shaft member passing through centers of the first and second rollers and the insulating ring member, a conductive pipe coupled to the rear end of the shaft member and electrically connected to any one of the first and second rollers, and a conductive rod installed along the hollows of the conductive pipe and the shaft member and electrically connected to any one of the first and second rollers; and a main body unit connected to the roller unit, a battery installed inside the main body case, a control circuit board for controlling power supplied to the first and second rollers, a control button for selecting current supplied to the first and second rollers, and an LED display for displaying the operating state.

An electrode arrangement is described that is configured to be coupled to a high voltage source for a dielectric barrier discharge plasma treatment of an irregularly three-dimensionally shaped surface of an electrically conducting body. The three-dimensionally shaped surface is used as a counter electrode. A first planar electrode is coupled to the high voltage source via a first lead, fitted to the object to be treated and brought in contact with a dielectric. A second electrode is contacted with the surface to be treated as reference electrode. The second electrode is provided in an edge portion that is circumferential to the first planar electrode and configured to be coupled to a reference voltage source via a second lead. An isolating cover layer covers the electrode and a third electrode covers the isolating cover layer as a ground electrode.

An electrode for electroporation comprising a plurality of electrode needles, wherein first polarity electrode needles, an electrode needle holding portion, and a syringe holding portion are provided; two or more first polarity electrode needles project from a bottom surface of a lower structural body of an outer frame support of the electrode needle holding portion toward an electroporation target side; the bottom surface of the lower structural body of the outer frame support is provided with a hole for syringe needle insertion and removal communicating with a syringe holding portion side; the syringe holding portion is provided on a side opposite to the electroporation target side of the electrode needle holding portion; and the syringe holding portion has a path for syringe needle insertion and removal, at least a portion of the path for syringe needle insertion and removal being provided with an electro-conductive portion for a second polarity.

It is provided a method and device for delivering transdermally a molecule non-invasively to a subject comprising irreversibly electroporating a region of the skin.

Various aspects of the present disclosure are directed towards apparatuses, systems and methods that may include an electroporation ablation device. The electroporation ablation device may include a shaft defining a longitudinal axis and an electrode assembly including a first pair of electrodes having a first electrode and a second electrode, and a second pair of electrodes disposed adjacent to the first pair of electrodes and having a third and a fourth electrode. In some embodiments, the first electrode has a first edge portion, and a first side view of the first edge portion along the longitudinal axis is rounded at a first corner.

A device for treating human keratinous material, in particular with the aid of an electric current. The device includes a reservoir containing a composition, in particular cosmetic or dermatological, to be applied to the keratinous material, and an end fitting for the application of the composition contained in the reservoir, the end fitting comprising a plurality of application members and a distributor. The distributor includes at least one storage cavity for the composition and supply orifices to conduct the composition from the storage cavity or cavities to the application members, and the distributor being configured so that the flow rate of the composition arriving at the application members is identical to within 20% for at least two application members, better for each application member.

A nerve in a mammal is optogenetically transduced, wherein the nerve is susceptible to stimulus by selective application of transdermal light, and a light source is applied to dermis of the mammal at or proximate to the optogenetically transduced nerve, to thereby stimulate the nerve. A wearable device for optogenetic motor control and sensation restoration of a mammal includes a wearable support, a power source at the wearable support, a controller at the wearable support and in electrical communication with a power source, and a transdermal light source coupled to the controller.