Embodiments of the disclosure concern methods and compositions for treating a subject with cancer, including overcoming resistance to a cancer drug using non-invasive radiotherapy frequency in combination with cancer drugs. In particular embodiments, radiofrequency therapy and cancer drugs in combination provide a synergistic benefit for cancer therapy. Use of radiofrequency therapy is an effective means to facilitate transport and perfusion of the cancer drugs in the subject.

Provided is a targeted drug delivery device for antitumor magnetic nanoparticle drugs including a transfusion container for accommodating antitumor magnetic nanoparticle drugs and a drug solution conveying device connected to the transfusion container and used for conveying the antitumor magnetic nanoparticle drugs. A magnetic field generating device capable of producing magnetic adsorption to the antitumor magnetic nanoparticle drug and a bioelectric sensor for sensing the response of living tissues in a tumor region to magnetic stimulation are arranged at an external position of the human body corresponding to the tumor region. The targeted drug delivery device is provided with a control unit for receiving and analyzing signals of the bioelectric sensor and providing a master control on the required magnetic field intensity, transfusion speed and liquid flow according to the signals of the bioelectric sensor.

The Body Cavity Cancer Treatment System achieves extremely uniform temperatures inside the tissue of the body cavity thereby realizing optimal efficacy in enhancing operation of the chemotherapy agent while avoiding harm or pain to the patient. This is accomplished by the inclusion of target particles, such as nano-particles, into the body cavity along with the chemotherapy agent to enable the use of an externally generated energy field to cause heating of the chemotherapy agent and the surrounding tissue of the body cavity by the activation of the nano-particles. The proper selection of the applied energy field enables precise control of the heat generated by the movement of the nano-particles.

A predetermined spatial locale is selectively operationally stimulated through local heating by exposing magnetic particle(s) associated with such local to alternating magnetic field parameters of which are chosen to generate hysteretic losses in magnetic particle(s). When different types of particles are associated with different locales such as different biological cells, different cells can be accessed and stimulated independently from one another. Switching between stimulation of first and second types of cells is carried out by changing parameters of stimulating magnetic field, while optionally maintaining the field strength-frequency product substantially constant. Embodiments facilitate multiplexed release of chemical payloads, triggering changes in electrical polarization, and changing a shape of a unit placed at the chosen locale.

The body cavity cancer treatment apparatus generates the magnetic field for use in a combined low temperature hyperthermia and ionizing radiation and/or chemotherapy cancer treatment protocol. Unlike other competing systems, the body cavity cancer treatment apparatus does not directly kill or ablate the cancer cells with killing temperatures rather, the body cavity cancer treatment apparatus stresses the cancer and cancer stem cells by keeping them at a nominal 42 C. for some period of time via the heating of nano-particles that have been infused into the bladder, using the generated magnetic field.

A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.

An apparatus and method for heating a treatment region of a subject by providing a substantially constant current across the treatment region is disclosed. The method includes positioning the treatment region between first and second electrodes connected to a generator operable to apply an alternating electric field between the electrodes. The method also includes displacing any air located between the treatment region and the first and second electrodes with one or more flowable materials that allow a substantially constant current to pass between the first and second electrodes and through the treatment region. The method further includes activating the generator to apply the alternating electric field between the first and second electrodes and across the treatment region to thereby heat the treatment region.

The current invention concerns systems, devices and methods for the ablation of a vessel's wall from the inside, more specifically to implant devices and to the ablation of the wall of one or more pulmonary veins (PV) from the inside, preferably transmural ablation and preferably at the level of the antrum. Hereby, one or more implant devices can be implanted in the vessels and can subsequently be heated by external energy-providing means.

A method for the treatment of tumor(s), tumor cell(s), cancer(s) in a subject by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternating magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes, and the agent is released within the tumors by heating the vesicle.

A vaginal device is described. A conformable vaginal insert is shaped for insertion into a vaginal cavity of a female human. A contact point is configured to change a shape of the insert. A sensor is configured to measure and to relay characteristics of the vaginal cavity and the surrounding and supportive structures of the vaginal cavity. A processor is configured to control the contact point to adjust the shape of the insert, generate a treatment for the vaginal cavity and the surrounding structures of the vaginal cavity and the supportive structures of the vaginal cavity comprising a vaginal cavity profile generated from the measured characteristics, store the measured characteristics and the vaginal cavity profile, and based on the stored measured characteristics and the stored vaginal cavity profile, automatically modify the shape of the insert by control of the contact point to provide the treatment to the vaginal cavity.