An illumination system for medical therapeutic and/or diagnostic system is provided. The illumination system includes a laser light source and a light guide. The light guide has a proximal end that is connectable and/or assignable to the one laser light source. The light guide has a distal end with a diffuser element having a radial, spherical emission characteristic. The diffuser element includes a diffuser main body made of an inorganic material, in particular a glass, a glass ceramic, a glass-like substance or a composite substance of the aforementioned substances. The diffuser main body has a scattering element and has a surface that is pore-free and smooth.

Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.

Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.

A microwave system comprises: a microwave generator; and a microwave cable apparatus comprising a coaxial cable, wherein an exposed distal portion of an inner conductor of the coaxial cable is longer than an outer conductor of the coaxial cable, and wherein at least part of the exposed distal portion of the inner conductor is bent with respect to a longitudinal axis of the coaxial cable, thereby to provide a directional radiating element; wherein the microwave generator is configured to provide microwave energy to the cable apparatus at a frequency that provides directional radiation of microwave energy having a desired directionality from the radiating element.

A method has been invented for intravenously inserting a tumor reduction radiation emitter into the body of a patient suffering from a cancerous tumor. The emitter is very small, yet detectable by medical imaging techniques and guidable by use of magnetism. The emitter is guided through the body by use of a magnet until it is adjacent or in in the tumor itself. The emitter can be oriented in various desired directions by the magnet. The emitter is then wirelessly powered by electrical induction, causing the radiation of a desired wavelength to be directed to tumor cells, causing tumor reduction.

A treatment method is disclosed capable of reducing the burden on a patient and enhancing the effect of killing tumor cells. The method includes administering an antibody-photosensitive substance into a vein; inserting an endoscope from a mouth, a nose, or an anus and bringing the endoscope to a vicinity of a tumor after the administering of the antibody-photosensitive substance into the vein; placing an optical fiber into the tumor or in the vicinity of the tumor; irradiating at least one of the tumor, the vicinity of the tumor, or a regional lymph node with a first near-infrared ray by the optical fiber; and irradiating the antibody-photosensitive substance bound to a tumor cell membrane in the tumor cell with a second near-infrared ray after the irradiating with the first near-infrared ray, the second near-infrared ray having a shorter wavelength than that of the first near-infrared ray.

A treatment method is disclosed capable of reducing the burden on a patient and enhancing the effect of killing tumor cells. A treatment method for killing a tumor cell, the method including inserting a catheter into a main artery of an organ having the tumor cell, administering an antibody-photosensitive substance into a vein before the inserting of the catheter, inserting an optical fiber into the catheter, reducing an influence of blood in the artery on a near-infrared ray, irradiating at least one of a tumor, the vicinity of the tumor, or a regional lymph node with a first near-infrared ray by the optical fiber, and irradiating an antibody-photosensitive substance bound to a tumor cell membrane in the tumor cell with a second near-infrared ray having a shorter wavelength than that of the first near-infrared ray.

Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.

An apparatus and methods for tissue restoration are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip, the catheter shaft defining lumens including an inflation lumen and a light fiber lumen, a coated balloon positioned on a translucent distal segment of the catheter shaft proximal to the distal tip in fluid communication with the inflation lumen, the coated distal balloon comprising a translucent material and a coated material on an outer surface of the coated balloon, and a light fiber positioned in the catheter shaft in the light fiber lumen and extending through the translucent distal segment.

Disclosed is a novel vascular optical fiber guidewire. The vascular optical fiber guidewire includes a metal axial wire and an optical fiber surrounding the metal axial wire. The optical fiber includes a core wire and a cladding layer covering the core wire. For above vascular optical fiber guidewire, in a part of the optical guidewire that is required to transmit light, a bending radius of the optical fiber around the metal axial wire is greater than a critical bending radius, and in a region of the optical fiber guidewire that is required to scatter light, the bending radius of the optical fiber around the metal axial wire is less than the critical bending radius. The present disclosure is capable of entering a blood vessel by a percutaneous puncture technique, guiding the optical fiber guidewire through a medical imaging device in a blood vessel, and performing side-illumination on the head.