A neural sensing system includes an interrogator that includes an optical head. The optical head is configured to transmit a light signal. The neural sensing system also includes a microprobe configured to contact tissue. The microprobe includes a transducer configured to receive the light signal and modulate the light signal with neural signal information sensed from the tissue. The microprobe also includes a retroreflector configured to reflect the modulated light signal back to the optical head of the interrogator.

An optical stimulation system includes a light source; an optical lead coupled, or coupleable, to the light source; at least one of a calibration table or a calibration formula, generated by a calibration procedure specifically using the light source and the optical lead of the optical stimulation system; and a control unit coupled, or coupleable, to the light source. The control module includes a memory to store the at least one of the calibration table or the calibration formula, and a processor coupled to the memory and configured for receiving a target light output level, using the at least one of the calibration table or the calibration formula to determine at least one operational parameter for generating the target light output level, and directing the light source, using the at least one operational parameter, to generate light at the target light output level.

A therapeutic lighting apparatus includes two white light sources each with a different color temperature and a controller. The controller operates the lighting apparatus in either a color temperature fusion mode or a color temperature flickering mode or both simultaneously such that the color temperature flickering mode can be used for treating a patient with Alzheimer's disease. The lighting apparatus can be enhanced with a green light source for supporting a green light mode for treating migraine headache. Similarly, the lighting apparatus can be enhanced with a red light source for supporting a red light mode for tissue repairing. Alternatively, the lighting apparatus can be enhanced with a near-infrared (IR) radiation source for supporting a near-IR mode for lowering the heartbeat, uplifting the mood, and improving the immunization system of a subject.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

A medical device that includes a carrier member, one or more operative components disposed in the carrier member, an optical fiber at least partly disposed in the carrier member, and at least one fiber Bragg grating (FBG) sensor array associated with the optical fiber and disposed in the carrier member. The carrier member includes an insertion end and side walls that contact the subject's body during positioning of the carrier member in the subject's body. The at least one FBG sensor array measures contact forces at one or both of the insertion end and along the side walls of the carrier member during positioning of the carrier member in the subject's body. A multi-core optical fiber configured for use in a medical device for positioning in a subject's body is also provided. A system and method for guiding positioning of a medical device in a subject's body is also provided.

Systems and methods of the present disclosure are directed to neural stimulation via non-invasive sensory stimuli. The non-invasive sensory stimuli can reduce neuroinflammation, improving synaptic plasticity and stimulating neural networking, and improving microglial-mediated clearance of cerebral insults, which would otherwise contribute to the progression of brain atrophy, by inducing synchronized gamma oscillations in at least one region of a brain in a subject. Stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stem from progression of brain atrophy.

A system for therapeutic treatments with electromagnetic waves is described. The system comprises an antenna and an apparatus configured to generate a supply current for the antenna in order to generate the electromagnetic waves. The apparatus comprises a digital processing circuit configured to generate a first PWM signal, a switching stage configured to generate an amplified PWM signal, an analog low-pass or band-pass filter configured to generate the supply current by filtering the amplified PWM signal, and a current sensor configured to provide a digital sample indicative of the amplitude of the supply current.

Specifically, the digital processing circuit generates a sequence of first digital values of a periodic base pulse. Moreover, the digital processing circuit generates a second PWM signal having a packet switch-on period and a packet switch-off period, generates a third PWM signal having a train switch-on period and a train switch-off period, and generates an enable signal as a function of the second PWM signal and the third PWM signal. The digital processing circuit generates then a second digital value, wherein the second digital value is set to the first digital value when the enable signal has a first logic level and to zero when the enable signal has a second logic level.

In particular, the digital processing circuit generates the first PWM signal as a function of a third digital value indicative of the duty cycle of the first PWM signal, and varies the third digital value via a discrete proportional-integral regulation configured to regulate the difference between the second digital value and the digital sample to zero.

An article of footwear is configured to be worn so as to at least partially cover a wearer's foot. The footwear includes at least one optical fiber on an internal surface of the footwear. The at least one optical fiber is configured to project radiation having a therapeutic wavelength through the at least one optical fiber and toward at least one of the wearer's foot, ankle or leg when the footwear is being worn so as to at least partially cover the wearer's foot.

Methods for selectively stimulating a plurality of light-responsive neurons in a sample are provided. Methods according to certain embodiments include irradiating a sample comprising a plurality of light-responsive neurons with a plurality of holographic images that are each configured to stimulate one or more light-responsive neurons in the sample, wherein the holographic images are created by light projection system that includes a plurality of light sources; a plurality of optical adjustment components; a plurality of spatial light modulators; a controller; a processor; and a computer-readable medium comprising instructions that, when executed by the processor, cause the controller to operate the light sources, optical adjustment components and spatial light modulators to generate and display a plurality of holographic images; direct each of the holographic images to a projection location; and project the holographic images onto the sample at a rate greater than 1 kHz. Light projection systems for irradiating a sample having light-responsive neurons with holographic images are also described.

One or more devices, systems, and methods are described which together provide sonoluminescence biophysical oscillation technique(s) (SBOT(s)) that improve debilitated states of health for individuals comprising; biophysical oscillations that initiate, sustain, and/or control one or more sound emitting devices including speakers capable of providing harmonic and subharmonic sound and including music and/or individual musical notes that provide sound tracsons and one or more light emission devices including projectors that provide light wave emission traclums which are capable of imparting color changes, wherein tracsons and traclums provide auditory and visual stimuli that result in energy changes that create acoustic and tracson/traclum excitations. The tracson/traclum excitations are applied in an external manner to one or more bodies of humans and in some cases could be applied to animals.