A device for the drying of tooth or bone surfaces includes a radiation source for irradiating the tooth or bone surface to be dried, a temperature sensor and/or a humidity sensor.

A therapeutic lighting apparatus includes two white light sources each with a different color temperature and a controller. The controller operates the lighting apparatus in either a color temperature fusion mode or a color temperature flickering mode or both simultaneously such that the color temperature flickering mode can be used for treating a patient with Alzheimer's disease. The lighting apparatus can be enhanced with a green light source for supporting a green light mode for treating migraine headache. Similarly, the lighting apparatus can be enhanced with a red light source for supporting a red light mode for tissue repairing. Alternatively, the lighting apparatus can be enhanced with a near-infrared (IR) radiation source for supporting a near-IR mode for lowering the heartbeat, uplifting the mood, and improving the immunization system of a subject.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Systems and methods of the present disclosure are directed to neural stimulation via non-invasive sensory stimuli. The non-invasive sensory stimuli can reduce neuroinflammation, improving synaptic plasticity and stimulating neural networking, and improving microglial-mediated clearance of cerebral insults, which would otherwise contribute to the progression of brain atrophy, by inducing synchronized gamma oscillations in at least one region of a brain in a subject. Stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stem from progression of brain atrophy.

A platinum(IV) complex has the structure of Formula I.

##STR00001##

where X, X′, Y, Y′, and Z are each independently an electron donor ligand, R.sub.1˜R.sub.5 are each independently a functional group, L is the linker unit, and n is selected from the group of 0, a positive charge, and a negative charge. Various methods contain steps for manufacturing the platinum(IV) complex, for treating cancer, a tumor, or an infection in a subject with the platinum(IV) complex. A pharmaceutical composition contains the platinum(IV) complex.

In one aspect, embodiments relate to a system for preventative dental laser treatment that ensures even irradiation of a laser beam. The system includes, a laser arrangement configured to generate the laser beam. The laser beam has one or more of a super-Gaussian energy profile and a transverse ring mode. The system also includes a focus optic. The focus optic is configured to converge the laser beam with a numerical aperture of 0.1 or less to a focal region. The system also includes a hand piece configured to direct the laser beam at a surface of a dental hard tissue. The system additionally includes a controller. The controller is configured to control one or more parameters of the laser source, such that a portion of the surface of the dental hard tissue is heated to a temperature in a range between 400° Celsius and 1300° Celsius.

Devices, systems, and methods can be used to deliver photobiomodulation therapy (PBMT) to the GI tract. For example, this document describes battery-enabled LED light source devices that can be deployed through or over an endoscope and anchored directly to the GI tract. Significant systemic effects can be produced by PBMT with application to one part of the body promoting beneficial anti-inflammatory and metabolic benefits in other remote sites promoted by enhanced mitochondrial function and mitokine signaling.

Near-infrared/Mid-infrared lasers are used to de-claudicate glaucomatous tissue, translocate extra-ocular muscles, thermally pulsate palpebrae, and penileate/vasodilate superficial/epi-scleral membranes for dmg delivery. Diffractive optic element-mediated laser patterns may irradiate eye tissues under pulsed or continuous wave regimes with programmable durations and sequences for efficient treatments while minimizing adverse effects.

An article of footwear is configured to be worn so as to at least partially cover a wearer's foot. The footwear includes at least one optical fiber on an internal surface of the footwear. The at least one optical fiber is configured to project radiation having a therapeutic wavelength through the at least one optical fiber and toward at least one of the wearer's foot, ankle or leg when the footwear is being worn so as to at least partially cover the wearer's foot.

In accordance with various aspects of the present teachings, systems and methods for applying treatment energy, e.g., electromagnetic radiation such as laser radiation in the visible and near infrared wavelengths, to body areas having bulges and fat deposits, loose skin, pain, acne and/or wounds. In some aspects, the systems and methods can enable relatively lengthy treatments to be performed by having the practitioner set-up and/or start the treatment, thereafter allowing the treatment to proceed safely and effectively without the continued presence of the practitioner.