Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

An optical stimulation system includes a light source configured to produce light for optical stimulation; a light monitor; an optical lead coupled, or coupleable, to the light source and the light monitor; and a control module coupled, or coupleable, to the light source and the light monitor. The control module includes a memory, and a processor coupled to the memory and configured for receiving a request for verification or measurement of a light output value; in response to the request, receiving, from the light monitor, a measurement of light generated by the light source; and, based on the measurement, reporting a response to the request.

A light irradiation device includes a first light source emitting first light in a visible wavelength band and a second light source emitting second light, in which at least part of a wavelength band is different from a wavelength band of the first light source and which catalyzes synthesis of a functional substance in a target to which light is applied. The second light includes light in a wavelength band of ultraviolet B.

A UV-C emitting phone case is provided that includes a main body defining a receiving cavity and a perimeter configured to receive and hold a mobile phone, surround a perimeter and a back portion of the phone. The phone case includes at least one UV-C light emitting diode (LED) positioned in the main body of the phone case and exposed on a back side of the phone case. It further includes a window for exposing the UV-C LED and optionally having a color metric to indicate if the light is being emitted, a power source built into the phone case and connected to the UV-C LED; an on/off switch coupled to the power source configured to activate and deactivate the UV-C LED; and an optional distance sensor to indicate a distance from a target surface to the UV-C LED.

The invention relates to a body irradiating device, in particular for irradiating a body of a person or a part of a body of a person, in particular with cosmetically and hygienically useful radiation, comprising a radiation source with a base and at least one first LED chip which can emit a first radiation spectrum with a first radiation peak and at least one second LED chip which can emit a second radiation spectrum with a second radiation peak differing from the first radiation peak. A body irradiating device allowing the radiation spectrum of more than one LED chip to be combined and uniformly supplied to the human body is achieved in that the first LED chip and the second LED chip are arranged below a common lens in an LED package and can be controlled separately.

A method for evaluating the effectiveness of a skin treatment on a skin feature includes correcting the color of a first image before the skin treatment, correcting the color of a second image after the skin treatment, determining the sizes of the skin feature in the first and second images, and comparing the corrected colors and sizes of the skin feature in the first and second images. In some embodiments, the first and second images include the skin feature and an indicator adjacent to the skin feature, where the indicator has a standard color and a known size.

A stimulation system includes an energy source, an electronics unit with a controller, and an actuator that is coupled with the electronics unit and/or the energy source. The actuator emits electromagnetic waves for stimulation of genetically manipulated tissue. The electronics unit is disposed in a housing. The stimulation system is configured for at least temporary implantation in a human or animal body. The controller controls the stimulation of tissue in the body by way of the electromagnetic waves emitted by the actuator. A selector of the stimulation system selects the area of the said tissue for stimulation. The selector includes a masking device for masking certain areas of the tissue, so that an intensity of the stimulation for the masked areas is reduced or equal to zero.

A nerve in a mammal is optogenetically transduced, wherein the nerve is susceptible to stimulus by selective application of transdermal light, and a light source is applied to dermis of the mammal at or proximate to the optogenetically transduced nerve, to thereby stimulate the nerve. A wearable device for optogenetic motor control and sensation restoration of a mammal includes a wearable support, a power source at the wearable support, a controller at the wearable support and in electrical communication with a power source, and a transdermal light source coupled to the controller.

A catheter is disclosed for performing ultraviolet light therapy in a pulmonary system of a patient, which includes a catheter body having opposed proximal and distal end portions, a handle assembly operatively associated with the proximal end portion of the catheter body, an illumination assembly operatively associated with the distal end portion of the catheter body and including an LED light source for generating UVC radiation, wherein the illumination assembly includes a coupler connecting the LED light source with the distal end portion of the catheter body, and an elongated braided sleeve disposed within the catheter body, wherein the coupler is adapted to transfer heat from the illumination assembly to the braided sleeve, such that the braided sleeve serves as a heat sink for the illumination assembly.

Methods of treating skin disorders are disclosed. The methods involve impinging light having a first peak wavelength on the tissue at a first radiant flux, wherein the first peak wavelength and the first radiant flux is selected to provide an anti-inflammatory effect, and impinging light having a second peak wavelength on the tissue at a second radiant flux, wherein the second peak wavelength and the second radiant flux are selected to either stimulate enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide or release nitric oxide from the endogenous stores are disclosed. Representative skin disorders include pruritus, psoriasis, acne, rosacea, and eczema, and the skin can include the scalp. The methods can reduce stinging and/or itching associated with the skin disorder. The anti-inflammatory wavelengths can be in the range of between about 650 and about 680 nm.