A product for use in treating a subject, incorporating a light-conversion medium which receives ambient light of broad spectrum, and emits light at one or more peak wavelengths or ranges of wavelengths (λ1, λ2, λ3) having greater intensity than corresponding intensity in the received broad spectrum ambient light. The products outlined are specifically designed for skin treatments of many different kinds, where the wavelengths chosen to have therapeutic or enhancing effects to the biological processes that occur inside or that directly affect the skin. The products can either exist as a unique treatment or be coupled with existing treatments in order to achieve an improved or differentiating result.

A device that is connectable to a phototherapy apparatus for applying targeted phototherapy to an area of skin to place a skin condition into remission and a method of determining a maximum tolerable dose of phototherapy applied to a treatment area to determine an optimum therapeutic dose to quickly place a skin condition into remission. The dosimetry device can include a housing and an optical matrix arranged within the housing. The optical matrix includes a plurality of at least one of absorptive, reflective and/or partially transmissive regions that each permits a different percentage of light to be delivered to an individual's skin. An assessment can then be made as to the maximum tolerable dose of phototherapy that can be applied to the individual's skin in order to place a skin condition into remission.

A method of performing a surgical procedure comprises inserting a medical instrument into anatomy of a patient to reach target tissue within an anatomical cavity, disinfecting anatomy within the patient with the medical instrument and performing treatment of the target tissue with the medical instrument. A medical device for providing disinfecting to a surgical site, the medical device comprises an elongate shaft extending from a proximal end to a distal end, an imaging device located proximate the distal end of the elongate shaft, a lighting element located proximate the distal end of the elongate shaft, a working channel extending at least partially through the elongate shaft and a disinfecting system attached to the elongate shaft to deliver a disinfecting capability proximate the distal end of the elongate shaft.

The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.

An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

A method, system and computer-readable medium of utilizing artificial lighting regulate a circadian clock of a human. By utilizing light emitting diodes (LEDs) that emit wavelengths associated with human opsin absorption spectra, a device may stimulate opsins in the human. For example, the device may replicate normal sunlight (e.g., based on season or time of day) by emitting light that changes in rhythmic intensity or spectral modulation.

A device for enhancement of visual appearance including a first applicator to be coupled to a first area of a body region, with a first magnetic field generating device and a first radiofrequency electrode, a second applicator to be coupled to a second area of the body region, with a second magnetic field generating device. The device further includes a first energy storage device, a second energy storage device, and a first switching device to discharge energy from the first energy storage device to the first magnetic field generating to generate a first time-varying magnetic field to cause muscle contraction, and a second switching to discharge energy from the second energy storage device to the second magnetic field generating device to generate a second time-varying magnetic field. The first radiofrequency electrode may provide first radiofrequency waves causing heating of tissue within the first area of the body region.

A light irradiation device includes a first illumination optical system to emit first light that causes a chemical reaction on an object; a second illumination optical system to emit second light having a wavelength different from a wavelength of the first light; a light emitter to emit the first light from the first illumination optical system and the second light from the second illumination optical system to the object in space shared by the first light and the second light, to irradiate an irradiation area on the object; an image-capturing optical system to capture an image of the space including the object; and circuitry configured to: detect a state of the irradiation area based on the image captured by the image-capturing optical system; and control at least one of the first light and the second light based on the detected state.

The disclosure is directed to systems and methods for treatment of periimplantitis using ultraviolet light. In some embodiments, the ultraviolet light is ultraviolet c light with a wavelength between 100 and 280 nanometers. In some embodiments, the ultraviolet c light makes the surface of the implant hydrophilic and more receptive to cell protein attachment. In some embodiments, an apparatus for treating periimplantitis using ultraviolet light includes a handpiece with a flexible neck and a rotatable tip at the end of the flexible neck. In some embodiments, the handpiece includes a contra angle dental handpiece or a straight dental handpiece which can couple to and direct ultraviolet light from either an end firing tip or a side firing tip. In some embodiments, the handpiece is sized to enable UVC light to be directed to an exposed area of an implant facing toward one or more posterior portions of the oral cavity.

An antimicrobial urinary catheter device comprising a circumferential array of safe, antimicrobial lights around a urinary catheter directed for disinfecting the distal urethra, urethral meatus, and adjacent indwelling urinary catheter.