A single treatment catheter is provided for delivery of brachytherapy radiation in combination with intratumoral injection into tumor tissue with a single skin and tumor insertion site. The catheter also enables precise delivery of anti-cancer agents, such as immunotherapy or other medical substances, to specific locations within the tumor with radiographic confirmation of the injection delivery area and location.

A transparent loading apparatus (also referred to herein as a “loader”) may partially or entirely comprise transparent material that allows light to pass through the loader and provides the viewer (whether manual or automated) a view of a radioactive seed, a seed carrier, a loading needle, etc. within the loader. In some embodiments, carrier material (e.g., collagen and/or other biocompatible material) and radioactive seeds (e.g., including a metal shielding and radioactive isotope) may transmit light to different degrees. For example, certain carriers, such as collagen carriers, may be translucent, while seeds may be opaque (or mostly opaque) to light. The systems discussed herein allow a viewer to detect location of a seed within a loader, and even within a carrier, because of these different light transmissivity characteristics.

A non-compliant medical balloon may be changed from a deflated state to an inflated state by increasing pressure within the balloon. The non-compliant medical balloon is composed of a woven fabric layer composed of at least two woven fabric fibers forming an angle. The angle remains substantially unchanged when the balloon changes from a deflated state to an inflated state.

A modular applicator for enabling a brachytherapy treatment comprising a central element and one or more of peripheral elements, wherein the central element is adapted with a fixation mechanism having a core for affixing the said peripheral elements thereto, wherein the fixation mechanism prevents a rotational displacement of the peripheral elements attached to the core of the fixation element with respect to the central element.

A processing device (1) and method for determining a position and/or orientation for a multi-hole grid template in a medical interventional procedure is disclosed. An anatomical spatial information processing unit (2) receives and/or processes data representative of a target spatial volume in the body, and a grid position sampler (4) generates candidate positions of the grid template. A quality calculator (5) calculates, for each candidate, a quality metric indicating the suitability of the candidate position of the grid template for the interventional procedure. A position selector (6) selects the position and/or orientation from the candidates based on the quality metric. For each candidate, an spatial relationship between each grid hole trajectory and the target volume is determined, and the quality metric takes, at least, this spatial relationship into account.

An intervention system employs an optical shape sensing tool (32) (e.g., a brachytherapy needle having embedded optical fiber(s)) and a grid (50, 90) for guiding an insertion of the optical shape sensing tool (32) into an anatomical region relative to a grid coordinate system. The intervention system further employs a registration controller (74) for reconstructing a segment or an entirety of a shape of the optical shape sensing tool (32) relative to a needle coordinate system, and for registering the needle coordinate system to the grid coordinate system as a function of a reconstructed segment/entire shape of the optical shape sensing tool (32) relative to the grid (50, 90) (i.e., reconstruction of a segment/entire shape of the OSS needle inserted into/through the grid serving as a basis for the grid/needle coordinate system registration).

Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.

An afterloading device for effectuating a brachytherapy treatment, comprising a first elongated flexible transport element, arranged to maneuver a radiation source between a storage position inside the afterloading device and a treatment position outside the afterloading device, the afterloading device further comprising a second elongated flexible transport element, having at least one transducer, the second transport element being arranged to move the at least one transducer between a first transducer position and a second transducer position.

A brachytherapy template adaptor for performing brachytherapy procedures using needles smaller in diameter than the template is designed to accommodate. Additionally, a kit for adapting a brachytherapy template is provided.

Systems, methods, and apparatuses are provided for an advanced gynecological applicator. In accordance with some embodiments, a brachytherapy applicator head and assembly is provided. The assembly may include two ovoid tubes configured to receive radiation sources, the two ovoid tubes combining to form a rounded applicator having a middle opening and comprising a plurality of needle holes to guide interstitial needles. The assembly may also include a central applicator tube configured to receive a radiation source that is located within the middle opening. Additionally, the assembly may include a vaginal cap that includes a tool-free connection to the two ovoid tubes and includes needle guides that align with the needle holes of the two ovoid tubes. The assembly may include a one-piece template for securing interstitial needles. The assembly may further include a tool-free connector to secure the two ovoid tubes to the central applicator tube.