The present invention relates to methods of treatment of acute myeloid leukemia with anti-CD38 antibodies.

Embodiments of the present disclosure are directed to treatment planning systems for a radiotherapy apparatus. In one implementation, a treatment planning system may include a computational processor configured to apply a set of instructions to an input data set. The input data set may include a three-dimensional dose distribution for delivery by the radiotherapy apparatus to a volume to be irradiated, a three-dimensional volume image characterizing tissue types within the volume to be irradiated, and a set of apparatus parameters which characterize the radiotherapy apparatus. The set of instructions may include a computational process configured to output a treatment plan for delivery of the dose distribution by the radiotherapy apparatus, by optimising a function representing a time-dependent response of the tissue types to an applied radiation.

A particle beam guiding system (1a, 1b, 1c) for receiving an incoming particle beam (6a, 6b, 6c) along an incoming trajectory (T1) and controlling an exit energy level and an exit trajectory (T3) of the particle beam, wherein the particle beam guiding system comprises an attenuator (22) for adjusting the energy level of the particle beam; a first beam guide (26) positioned downstream of the attenuator, comprising first and second guiding dipoles, each comprising two magnets for creating magnetic fields for deflecting the particle beam from the incoming trajectory into an intermediate trajectory (T2), wherein the first dipole of the first beam guide is arranged to deflect the particle beam in a first plane, and the second dipole of the first beam guide is arranged to deflect the particle beam in a second plane which is orthogonal to the first plane; and a second beam guide (28) positioned downstream of the first beam guide, comprising first and second guiding dipoles, each comprising two magnets for creating magnetic fields for deflecting the particle beam from the intermediate trajectory into the exit trajectory, wherein the first dipole of the second beam guide is arranged to deflect the particle beam in a first plane and the second dipole of the second beam guide is arranged to deflect the particle beam in a second plane which is orthogonal to the first plane. A radiotherapy system comprising such particle beam guiding systems is also disclosed.

Methods of treating cancer comprising administering to patients a dendritic cell mobilizing agent (e.g., Flt3 ligand) in combination with radiation and/or immunoregulatory agents (e.g., checkpoint inhibitors), are disclosed.

The present disclosure discloses a radiation treatment device and pertains to the field of medical appliance technologies. The radiation treatment device includes a radiotherapy unit and an imaging unit. The radiotherapy unit is configured to emit a treatment beam to a to-be-treated region in a patient, wherein the to-be-treated region in the patient is located outside the radiotherapy unit. The imaging unit is arranged adjacent to the radiotherapy unit and is configured to emit an imaging beam to the to-be-treated region in the patient. Without moving the to-be-treated region in a patient, the radiotherapy unit may emit the treatment beam to the to-be-treated region in the patient according to the treatment plan worked out to execute the radiation treatment, such that the accuracy of the radiation treatment is improved.

The present disclosure relates to a source body, a radiotherapy device and a drive method thereof, belonging to the field of medical technologies. The source body is provided with a plurality of radioactive sources, and an angle between the plurality of radioactive sources in a longitudinal direction is within a preset angle range. The source body, the radiotherapy device and the drive method thereof can protect sensitive tissues and organs in a treatment process.

Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point during a given radiation session, a first imaging slice comprising an object, the first imaging slice corresponding to a first plane; accessing, at the first time point during the given radiation session, a composite imaging slice corresponding to the first plane, the composite imaging slice being generated using a plurality of imaging slices obtained prior to the first time point; spatially registering the first imaging slice and the composite imaging slice; determining movement of the object using the spatially registered first imaging slice and the composite imaging slice; and generating an updated therapy protocol to control delivery of a therapy beam based on the determined movement.

Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point in a given radiation session, a first imaging slice corresponding to a first plane; encoding the first imaging slice to a lower dimensional representation; applying a trained machine learning model to the encoded first imaging slice to estimate an encoded version of a second imaging slice corresponding to a second plane at the first time point to provide a pair of imaging slices for the first time point; simultaneously spatially registering the pair of imaging slices to a volumetric image, received prior to the given radiation session, comprising a time-varying object to calculate displacement of the object; and generating an updated therapy protocol to control delivery of a therapy beam based on the calculated displacement of the object.

The inventive alignment frame simplifies the task of attaching a fixation frame to a patient's skull prior to radiotherapy treatments. The frame is adjustably attachable to the fixation frame and is equipped with a bite plate that allows a patient to bite down on the bite plate to immobile the alignment-calibration frame and the attached fixation frame. The positional relationships are adjusted to bring the fixation screws into optimal locations on the patient's skull. Needle calibration assemblies placed into the fixation screw holders include clear needle guides through which a hypodermic needle is inserted to inject anesthetic into the future fixation screw location. The needle calibration assemblies are removed and the optimal length fixation screw is tightened into the anesthetized location. After all the fixation screws are in place, the patient releases the bite plate and the entire alignment-calibration frame is removed from the fixation frame.

The invention relies on a medical device for an intracorporeal location, wherein: it comprises a deformable armature, at least partially made of a shape memory material and having an Ea end and an Eb end, said Ea end being larger than said Eb end, it has an essentially triangular, trapezoidal, ovally or diamond-shaped, the sides of which extending between said Eb end and the corners of said Ea end, said deformable armature optionally includes a middle rip extending from said Ea end to said Eb end and multiple cross elements extending between the middle rip and said sides, wherein said sides are formed by sides braces, it comprises at least one x-ray visible marker fixed at the deformable armature selected from the group consisting of gold, silver, platinum, tantalum, tungsten, niobium, palladium, iridium, it comprises a guide suited for the intracorporeal introduction of said medical device, and an extraction holder of the medical device.

The invention also relies on a device for the introduction, by an endoscopic or percutaneous way, of the medical device, and on a method for accurately targeting a target area during radiation treatment through image guidance comprising determining the location of the medical device in real time using at least one method of targeting selected from the group consisting of lasers, visual, infrared, MRI/MRS, RF and radiation; and modifying the radiation treatment beam path to adaptively compensate for a change in position of the target area.