A radiation therapy system comprises a magnetic resonance imaging (MRI) system combined with an irradiation system, which can include one or more linear accelerators (linacs) that can emit respective radiation beams suitable for radiation therapy. The MRI system includes a split magnet system, comprising first and second main magnets separated by gap. A gantry is positioned in the gap between the main MRI magnets and supports the linac(s) of the irradiation system. The gantry is rotatable independently of the MRI system and can angularly reposition the linac(s). Shielding can also be provided in the form of magnetic and/or RF shielding. Magnetic shielding can be provided for shielding the linac(s) from the magnetic field generated by the MM magnets. RF shielding can be provided for shielding the MRI system from RF radiation from the linac.

Disclosed herein are systems, methods, and computer-readable storage devices for manufacturing patient-specific bolus for use in targeted radiotherapy treatment. Based on dose calculations without a bolus and based on three-dimensional scan data of a patient, the example system generates a model of a bolus for targeting radiotherapy treatment to a planning target volume or target region within the patient. The system can perform several iterations to generate a resulting model for the bolus. Then, the system can generate instructions for controlling a three-dimensional printer to generate the bolus that conforms to the patient's skin surface while also specifically targeting the planning target volume for the radiotherapy treatment. In this way, the amount of radiotherapy treatment administered to other tissue is reduced, while the costs, time, and human involvement in creating the bolus are significantly reduced.

Provided is a treatment planning system. The treatment planning system is configured to acquire a mode selection instruction, a first image of a subject to be treated and contour data of target tissue; select a mode corresponding to the subject to be treated from a plurality of treatment planning modes based on the mode selection instruction; and produce a treatment plan based on the mode corresponding to the subject to be treated, the first image and the contour data, wherein the plurality of treatment planning modes are configured to produce treatment plans for a plurality of treatment heads that generate different types of ray beams.

An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.

A system (and associated method) for treating a human or animal body. The system has a photoactivatable drug for treating a first diseased site, a first pharmaceutically acceptable carrier including one or more phosphorescent or fluorescent agents which are capable of emitting an activation energy into the body which activates the photoactivatable drug, a first device which infuses the first diseased site with a photoactivatable drug and the first pharmaceutically acceptable carrier, a first energy source which irradiates the diseased site with an initiation energy to thereby initiate emission of the activation energy into the body, and a supplemental treatment device which administers one or both of a therapeutic drug or radiation to the body at a second diseased site or the first diseased site, to provide an immune system stimulation in the body.

Radionuclide brachytherapy sources and systems for applying beta radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems herein provide a substantially uniform dose across a particular area, thereby providing appropriate radiation therapies.

The present application relates to activable inorganic nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cancerous cells, tissues or organs. It more particularly relates to nanoparticles which can generate a surprisingly efficient therapeutic effect, when concentrated inside the tumor and exposed to ionizing radiations. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.

Disclosed herein is a method of determining the nature of a fault in a radiotherapy device comprising a linear accelerator. The radiotherapy device is configured to provide therapeutic radiation to a patient. The radiotherapy device comprises a bending magnet assembly arranged to direct a beam of electrons toward a target to produce said radiation. A first sensor is configured to provide signals indicative of voltage at a first region of the bending magnet assembly. The method comprises receiving voltage values derived from the signals from the first sensor and processing the voltage values; wherein processing the voltage values comprises determining whether the voltage values meet at least one threshold criterion; and, based on the processing of the signals, determining whether the nature of the fault is associated with the bending magnet.

An applicator for intraoperative radiotherapy with low-energy X-ray radiation includes an applicator body, an air-permeable outer surface with a circumferential outer face and with a distal end, a receiving device which is arranged at a proximal end and with which the applicator can be secured to an X-ray irradiation device, and an inner recess which has an opening at the proximal end and into which an X-ray radiation source is insertable. The applicator has a solid porous structure on its outer surface which provides the air-permeable outer surface with a rigid shape. The solid porous structure forms a continuous air-permeable channel structure which is connected in an air-conducting manner to the proximal end of the applicator.

A system for monitoring radiation treatment images Cherenkov emissions from tissue of a subject. A processor of the system determines densities of a surface layer of the subject from 3D images of the tissue to determine correction factors. The processor uses these factors to correct the Cherenkov images for attenuation of Cherenkov light by tissue, making them proportional to radiation dose. In embodiments, the system obtains reflectance images of the subject, determines second correction factors therefrom, and applies the second correction factors to the Cherenkov emissions images. In embodiments, the corrected images of Cherenkov emissions are compared to dose maps of a treatment plan. A method of correcting Cherenkov emissions images includes determining tissue characteristics from CT or MRI images in a surface volume where Cherenkov is expected, using; imaging Cherenkov emissions; and using the tissue characteristics to correct the images for variations in Cherenkov light propagation through the tissue.