Systems and methods for determining beam asymmetry in a radiation treatment system using electronic portal imaging devices (EPIDs) without implementation of elaborate and complex EPID calibration procedures. The beam asymmetry is determined based on radiation scattered from different points in the radiation beam and measured with the same region of interest ROI of the EPID.

The present invention provides improved methods and apparatus that use machine vision techniques to rapidly and automatically guide objects into desired docking configurations. The present invention is based at least in part upon using multi-depth, rotationally symmetric targets that are observed from two or more observation perspectives. By taking advantage of parallax effects associated with the multi-depth topography of the target, the apparent positions of target features in captured image information encodes position and angular alignment of the objects relative to each other in three dimensional space. The practice of the present invention provides a fast, accurate, reliable and automatic approach to achieve hard or soft docking configurations in the electron beam therapies as well as to implement real-time gating and tracking during the course of a treatment.

Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

The present application relates to activable inorganic nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cancerous cells, tissues or organs. It more particularly relates to nanoparticles which can generate a surprisingly efficient therapeutic effect, when concentrated inside the tumor and exposed to ionizing radiations. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.

A multi-robotic arm apparatus for intraoperative radiotherapy is provided. The apparatus may comprise a chassis, a main robotic arm mounted on the chassis for moving a radiation head installed at an end thereof, a first robotic arm mounted on the chassis having a first robotic arm end gripper for gripping an imaging device or a treatment applicator; and a second robotic arm mounted on the chassis having a second robotic arm end gripper for gripping a simulation applicator.

A device for concentrating ionizing radiation fluence is disclosed having a coupling structure linking the external radiotherapy device with linear accelerator to an external structure, whose central axis is hollow with an input window through which electrons enter attaching to the rotation device; a rotation system linking the coupling structure with a coupling flange rotating an inner structure; a deflection system in the inner structure, wherein the deflection system has first and second magnetic deflection devices; a system for controlling the focal point, which is in the electron deflection system, having an electronic control system controlling a set of motors that produce coordinated movements of the second magnetic deflection device, a correction element and a collimator, which change the position of the focal point; and at least two laser diodes on the edge of the collimator (25) pointing towards the focal point determining the position of the electron beam generated.

According to the present invention, disclosed is a radiotherapy apparatus for an animal, comprising: a treatment part including an accommodation space for placing an animal thereon; an irradiation part including an electron generator and a linear accelerator coupled to one side of the electron generator and placed in a direction perpendicular to the treatment part for emitting radiation toward the treatment part; and an image acquisition part, positioned at a predetermined interval with the treatment part along the direction of the emitting of radiation, for acquiring an image of an irradiation area when radiation is emitted, wherein an output of radiation is between 1 and 2 MeV so that radiation is emitted to an affected area positioned within a predetermined distance from the epidermis of the animal.

An external beam radiation therapy method is described, wherein radiation therapy is performed on a subject by applying at least one ionizing radiation beam to the subject. While applying the at least one ionizing radiation beam to the subject, an ultrasound probe images the subject, where the ultrasound probe is not located in the ionizing radiation beam. While applying the ionizing radiation beam to the subject, a dosimeter that is integral with or attached to the ultrasound probe measures the radiation dose or radiation exposure received by the ultrasound probe.

Systems and methods provide radiotherapy treatment by focusing an electron beam on an x-ray target (e.g., a tungsten plate) to produce a high-yield x-ray output with improved field shaping. A modified electron beam spatial distribution is employed to scan the x-ray target, such as a 2D periodic beam path, which advantageously lowers the x-ray target temperature compared to the typical compact beam spatial distribution. As a result, the x-ray target can produce a high yield output without sacrificing the x-ray target life span. The use of a 2D periodic beam path allows a much colder x-ray target functioning regime such that more dosage can be applied in a short period of time compared to existing techniques.

In one aspect, a connector assembly includes a delivery conduit defining a conduit lumen and a securable connector configured to secure the delivery conduit to a medical device hub defining a medical device hub lumen. The conduit lumen includes a constant diameter region along a portion of the delivery conduit and a transition region extending from the delivery conduit to the distal end. A transition region diameter of the transition region gradually increases from the constant diameter region to a distal end of the delivery conduit. The securable connector is coupled to an outer surface of the delivery conduit and is slidable along a portion thereof. The securable connector is configured to receive the medical device hub. The securable connector is secured relative to the delivery conduit so as to fluidically couple the conduit lumen with the medical device hub lumen.