An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.

The disclosure provides a radiotherapy system, comprising: a bed, for supporting the patient; and a bridge, comprising one or more rolling elements for supporting the bed and allowing the bed to be moved along a surface of the bridge. The one or more rolling elements are located at respective fixed positions in the bridge.

Multiphase microspheres for radioembolization include two-phase microspheres and three-phase microspheres prepared by a microfluidic process. The multiphase microspheres include a primary phase and a first secondary phase surrounded by the primary phase. The primary phase includes a first resin. The first secondary phase includes a second resin and at least one of a radioactive isotope or a compound including at least one radioactive element. Three-phase microspheres additionally include a second secondary phase discrete from the first secondary phase and also surrounded by the primary phase. The second secondary phase may be a gas such as air. The microspheres may be formed by a microfluidic process.

A dose rate-volume histogram is generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. An irradiation time-volume histogram can also be generated for the target volume. The irradiation time-volume histogram can be stored in computer system memory and used to generate the radiation treatment plan.

Described herein is a medical linear accelerator including an accelerator target structure constructed of a material having a thickness of less than 0.2 radiation lengths, and an accelerator structure to receive an electromagnetic wave and generate an output therapy dose rate of electrons having a beam energy between 4-25 mega-electronvolts (MeV).

A radiation therapy system comprises a magnetic resonance imaging (MRI) system combined with an irradiation system, which can include one or more linear accelerators (linacs) that can emit respective radiation beams suitable for radiation therapy. The MRI system includes a split magnet system, comprising first and second main magnets separated by gap. A gantry is positioned in the gap between the main MRI magnets and supports the linac(s) of the irradiation system. The gantry is rotatable independently of the MRI system and can angularly reposition the linac(s). Shielding can also be provided in the form of magnetic and/or RF shielding. Magnetic shielding can be provided for shielding the linac(s) from the magnetic field generated by the MRI magnets. RF shielding can be provided for shielding the MRI system from RF radiation from the linac.

The present application relates to activable inorganic nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cancerous cells, tissues or organs. It more particularly relates to nanoparticles which can generate a surprisingly efficient therapeutic effect, when concentrated inside the tumor and exposed to ionizing radiations. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.

Systems and methods for using electronic portal imaging devices (EPIDs) as absolute radiation beam measuring devices and as radiation beam alignment devices without implementation of elaborate and complex calibration procedures.

A radiotherapy equipment including: a rotating gantry, an X-beam generating assembly and a treatment couch. The X-beam generating assembly is on the rotating gantry, rotates about a rotation axis of the rotating gantry driven by the rotating gantry, and generates an X-beam deflected with respect to a rotating plane of the rotating gantry in a direction of the rotation axis, and the rotating gantry and the X-beam generating assembly are stationary in the direction of the rotation axis. The treatment couch is on a side of the rotating gantry for supporting a patient, and moves along the direction of the rotation axis to cooperate with a deflection of the X-beam to irradiate a target of the patient with the X-beam.

Methods and systems for selection of dosimetry levels and sphere amounts of radioactive compounds for use in a radioembolization procedure for procedure planning may include inputting activity parameter information into a dosimetry portal of a dosimetry selection tool; determining a customized activity based on the activity parameter information and one or more customized activity algorithms; generating one or more sphere amount and dosage recommendations based on the customized activity and one or more dosimetry selection algorithms; selecting one of the one or more sphere amount and dosage recommendations as a selected sphere amount and dosage recommendation; and generating a radioactive compound order for the radioembolization procedure based on the customized activity and the selected sphere amount and dosage recommendation.