Disclosed are a method of measuring concentration distribution of boron for boron neutron capture therapy (BNCT) using magnetic resonance imaging (MRI) alone and a treatment planning method for BNCT. The methods include (a) acquiring an anatomical image of a patient and measuring a boron concentration from magnetic resonance (MR) data, (b) extracting a boron concentration change prediction parameter of the patient and predicting the concentration over time, (c) calculating and verifying a boron distribution prediction value estimated by boron imaging and spectral analysis, and (d) deriving an optimal time for BNCT based on the verified results.

Systems, devices, and methods for converting a raw neutron beam to a specified deliverable format having a targeted energy range, size, and direction are described. Embodiments of a neutron beam converter can include numerous regions based on location, function, dimension, and/or constituent material. The regions can include a central region, an intermediate region, a peripheral region, and a frontal region. Materials are also described.

An apparatus comprising a radiation source, coincident positron omission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.

A patient-positioning device and a medical workstation including the patient-positioning device. The patient-positioning device includes a patient couch and a robot arm which is provided for moving the patient couch and which comprises several links arranged one after another and mounted rotatably with respect to axes. The robot arm includes, as links, a start link, a first link, a second link, a third link, a fourth link, a fifth link and a sixth link. The robot arm comprises a patient couch or a fastening device on which the patient couch is fastened.

Disclosed are a radiotherapy system and a treatment plan generation method therefor. The radiotherapy system includes a beam irradiation device, a treatment planning module and a control module. The beam irradiation device generates a beam for treatment and irradiates same to a body to be irradiated to form an irradiated site, the treatment planning module generates a treatment plan on the basis of parameters of the beam for treatment and medical image data of the irradiated site, and the control module retrieves a treatment plan corresponding to said body from the treatment planning module and controls the beam irradiation device to sequentially irradiate said body according to at least two irradiation angles determined according to the treatment plan generation method and the irradiation time corresponding to each irradiation angle.

Disclosed are a neutron capture therapy device and an operation method of a monitoring system. The neutron capture therapy device includes a neutron beam irradiation system, a detection system and the monitoring system. The neutron beam irradiation system generates a neutron beam for performing neutron irradiation therapy on a sick body. The detection system is used for detecting irradiation parameters during a neutron beam irradiation therapy, and the monitoring system is used for controlling the whole neutron beam irradiation process. The monitoring system includes a storage part for storing the irradiation parameters, a control part for executing a therapy plan according to the irradiation parameters stored in the storage part, and a correction part for correcting part of the irradiation parameters stored in the storage part. The disclosure improves the accuracy of the dosage of the neutron beam for irradiating the sick body.

Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula: ##STR00001##
or a salt therof. R.sub.1 includes a chelating agent that is chelated to a gadolinium atom; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl; R.sub.2 is —N.sup.+H.sub.3, —N.sup.+H.sub.2Z, —N.sup.+HZ.sub.2, or —N.sup.+Z.sub.3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.

The present disclosure may disclose methods and systems for treating an object. The method may include imaging an object fixed on a positioning device using an imaging device. The method may include obtaining a plan image of the object. The method may include generating information of a region of interest (ROI) of the object based on the plan image of the object. The method may include generating a treatment plan based on the information of the ROI. The treatment plan may include a plan isocenter on the plan image. The method may further include treating a target portion of the object based on the treatment plan using a treatment device. The object may be fixed on the positioning device from a moment that the object is started to fixed on the positioning device to an end of the treatment of the target portion.

The invention provides a radiotherapy system and a method for controlling safety interlock thereof. The radiotherapy system includes a beam generating apparatus, which includes a charged particle beam generating apparatus and a neutron beam generating portion interacting with a charged particle beam generated by the charged particle beam generating apparatus to generate a therapeutic neutron beam to irradiate into a first irradiation chamber. In operation, the radiotherapy system determines whether there is a safety problem by a beam control module according to the received operation data of the charged particle beam generating apparatus or by a system control module according to the received operation data of the radiotherapy system, and the beam control module or the system control module controls the charged particle beam generating apparatus through the beam control module, to generate the charged particle beam or not, or interact with the neutron beam generating portion.

To provide a BNCT treatment system capable of formulating a neutron irradiation mode based on diagnostic data on a subject to be treated. A BNCT treatment system 2, used for performing neutron capture therapy, includes: a Hexatron 3 including first to sixth neutron irradiation devices 3A to 3F which emit neutrons; and a controller 4 configured to control neutron irradiation by the first to sixth neutron irradiation devices 3A to 3F. The BNCT treatment system 2 includes: an HOP 5 configured to formulate a treatment plan (a mode for controlling neutron irradiation of the first to sixth neutron irradiation devices 3A to 3F by the controller 4) based on diagnostic data on a patient PA; an HSP 6 configured to monitor each component member; and a management unit 7 configured to manage the entire system.