A radiation treatment apparatus includes an accelerator that emits a charged particle beam, a time measurement unit that measures an emission time of the charged particle beam of the accelerator, a first control unit that controls the accelerator based on the emission time measured by the time measurement unit, and an emission determination unit that determines whether or not the accelerator is emitting the charged particle beam while the first control unit is controlling the accelerator. The time measurement unit adds a time, for which a result of a determination performed by the emission determination unit is that the accelerator is emitting the charged particle beam, to the emission time and does not add a time, for which the result of the determination performed by the emission determination unit is that the accelerator is not emitting the charged particle beam, to the emission time.

Particle radiation therapy and planning utilizing magnetic resonance imaging (MRI) data. Radiation therapy prescription information and patient MRI data can be received and a radiation therapy treatment plan can be determined for use with a particle beam. The treatment plan can utilize the radiation therapy prescription information and the patient MRI data to account for interaction properties of soft tissues in the patient through which the particle beam passes. Patient MRI data may be received from a magnetic resonance imaging system integrated with the particle radiation therapy system. MRI data acquired during treatment may also be utilized to modify or optimize the particle radiation therapy treatment.

Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage.

Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

A treatment preparation apparatus includes a peripheral simulator that simulates a peripheral portion of the object after the object is disposed in the irradiation chamber, when fixing the relative position of the object to the irradiation target in the preparation chamber. Therefore, when positioning the patient in the preparation chamber, by using the peripheral simulator, the positioning can be performed in consideration of the peripheral portion of the object in the irradiation chamber. That is, in the preparation chamber, the patient can be fixed at a position in the irradiation chamber where shift is unlikely to occur, considering the positional relationship between the patient and the peripheral portion. From the above, when positioning the patient in the preparation chamber, it is possible to position the patient at a position that shift is unlikely to occur during irradiation.

Systems, devices, and methods for non-Gaussian energy distribution modeling for treatment planning algorithms used in particle radiation therapy.

Systems and apparatuses for providing particle beams for radiation therapy with a compact design and suitable to a single treatment room. The radiation system comprises a stationary cyclotron coupled to a rotating gantry assembly through a beam line assembly. The system is equipped with a single set of dipole magnets that are installed on the rotating gantry assembly and undertakes the dual functions of beam energy selection and beam deflection. The energy degrader may be exposed to the air pressure. The beam line assembly comprises a rotating segment and a stationary segment that are separated from each other through an intermediate segment that is exposed to an ambient pressure.

Particle radiation therapy and planning utilizing magnetic resonance imaging (MRI) data. Radiation therapy prescription information and patient MRI data can be received and a radiation therapy treatment plan can be determined for use with a particle beam. The treatment plan can utilize the radiation therapy prescription information and the patient MRI data to account for interaction properties of soft tissues in the patient through which the particle beam passes. Patient MRI data may be received from a magnetic resonance imaging system integrated with the particle radiation therapy system. MRI data acquired during treatment may also be utilized to modify or optimize the particle radiation therapy treatment.

Described herein are methods for reducing or maintaining the size of a tumor in a subject, where the method involves exposing the tumor to ionizing radiation and administering to the subject a modified hyaluronan or a pharmaceutically acceptable salt or ester. The use of the modified hyaluronan enhances or potentiates the effect of ionizing radiation used in cancer treatment. Additionally, the methods described herein prevent or reduces tumor regrowth in the subject after exposing the tumor to ionizing radiation and administration of the modified hyaluronan to the subject.

A neutron capture therapy system is provided, including a neutron generating device and a beam shaping assembly. The neutron capture therapy system further includes a concrete wall forming a space for accommodating the neutron generating device and the beam shaping assembly and shielding radiations generated by the neutron generating device and the beam shaping assembly. A support module is disposed in the concrete wall, the support module is capable of supporting the beam shaping assembly and is used to adjust the position of the beam shaping assembly, and the support module includes concrete and a reinforcing portion at least partially disposed in the concrete. The neutron capture therapy system designs a locally adjustable support for the beam shaping assembly, so that the beam shaping assembly can meet the precision requirement, improve the beam quality, and meet an assembly tolerance of the target.