Provided herein is a method of treating a traumatic brain injury in a subject in need thereof, the method including administering to the subject a therapeutically effective amount of radiation. The methods can improve motor function recovery and reverse motor function deficits after traumatic brain injury and/or ischemic stroke in a subject.

A method of scanning parameter optimization, which method may be useful with image-guided radiation therapy (IGRT), allows for controlling exposure of a beam from an x-ray source and/or controlling the detection mechanism for an x-ray detector of imaging radiation of a radiation-delivery device based on one or more parameters of a region of interest of a patient. The one or more parameters of the region of interest may include a dimension, outer contour, density, location relative to an outlet of the beam, location relative to isocenter, location to the whole patient body, etc. Exposure of the patient to the beam may be varied via modulation of one or more scanning parameters for controlling an aspect of the beam and/or the detector to provide for targeted and or reduced radiation exposure of the patient or portion of the patient, and/or for improved quality of guiding images. The modulation may be varied depending on a view angle of the region of interest from a portion of the radiation-delivery device.

Systems and methods for determining beam asymmetry in a radiation treatment system using electronic portal imaging devices (EPIDs) without implementation of elaborate and complex EPID calibration procedures. The beam asymmetry is determined based on radiation scattered from different points in the radiation beam and measured with the same region of interest ROI of the EPID.

An x-ray imaging apparatus and associated methods are provided to receive measured projection data from a wide aperture scan of a wide axial region and a narrow aperture scan of a narrow axial region within the wide axial region and determine an estimated scatter in the wide axial region using an optimized scatter estimation technique. The optimized scatter estimation technique is based on the difference between the measured scatter in the narrow axial region and the estimated scatter in the narrow axial region. Kernel-based scatter estimation/correction techniques can be fitted to minimize the scatter difference in the narrow axial region and thereafter applying the fitted (optimized) kernel-based scatter estimation/correction to the wide axial region. Optimizations can occur in the projection data domain or the reconstruction domain. Iterative processes are also utilized.

Multimodal imaging apparatus and methods include a rotatable gantry system with multiple sources of radiation comprising different energy levels (for example, kV and MV). Fast slip-ring technology and helical scans allow data from multiple sources of radiation to be combined or utilized to generate improved images and workflows, including for IGRT. Features include increasing the precision of spatial registrations between respective image sets to allow more precise radiation treatment delivery, reducing image artifacts (e.g., scatter, metal and beam hardening, image blur, motion, etc.), and utilization of dual energy imaging (e.g., for material separation and quantitative imaging, patient setup, online adaptive IGRT, etc.).

A patient supporting device includes: a base; a positioner; a platform having a first end and a second end; and a controller; wherein the positioner is operable by the controller to place the platform at one of a first plurality of possible positions or at one of a second plurality of possible positions, wherein in any of the first plurality of possible positions, the second end of the platform is closer to one of a left side and a right side of a treatment machine; wherein in any of the second plurality of possible positions, the second end of the platform is closer to another one of the left side and the right side; and wherein a size of a first spatial region defined by the first plurality of possible positions is different from a size of a second spatial region defined by the second plurality of possible positions.

An x-ray imaging apparatus and associated methods are provided to process projection data from an offset detector during a helical scan, including view completion. The detector may be offset in the channel and/or axial direction. Projection data measured from a current view is combined with projection data measured from at least one conjugate view to reconstruct a target image. A two-dimensional aperture weighting scheme is used to address data redundancy.

This invention relates the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.

According to some aspects, an x-ray apparatus for imaging and/or radiation therapy is provided, the x-ray apparatus comprises an electron source capable of generating electrons, at least one first target arranged to receive electrons from the electron source, the at least one first target comprising material that, in response to being irradiated by the electrons, emits broad spectrum x-ray radiation, at least one second target arranged to receive at least some of the broad spectrum x-ray radiation, the at least one second target comprising material that, in response to irradiation by broad spectrum x-ray radiation from the first target, emits monochromatic x-ray radiation, and at least one detector positioned to detect at least some of the monochromatic x-ray radiation emitted from the at least one second target. According to some aspects, a relatively low cost, relatively small footprint x-ray apparatus for generating monochromatic x-ray radiation suitable for medical/clinical purposes and appropriate for use in existing medical facilities such as hospitals and/or small clinical settings is provided.

Automatic radiation therapy treatment planning for generating a plan to be delivered from at least one beam angle, using a collimator having a variable collimator angle. Delivery times are determined for a number of possible collimator angles, and the optimization problem is defined to take the delivery times into account when selecting the collimator angles to be used when delivering the radiation.