An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3D digital model according to the image data; creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region. By the use of different ultrasound transmitting sequences, ultrasound neuromodulation can be realized, and research on an action mechanism for the ultrasound neuromodulation can be performed.

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

A system to generate and sense electrical energy to and from tissue within a mammalian body. The system includes a flexible shaft and an electrical generator disposed on or embedded within the flexible shaft. Radially displaceable arcuate arm members forming electrodes are displaceable responsive to actuation of the electrical generator.

A device includes a first vibrational transducer and a second vibrational transducer. The first vibrational transducer has a first vibrating property. The second vibrotactile stimulator has a second vibrating property different than the first vibrating property. A collar may be configured to position the first vibrational transducer and the second vibrational transducer over a neck of a subject. A method for stimulating swallowing in a subject includes applying a first vibrotactile stimulation and applying a second vibrotactile stimulation to a throat area of the subject. The first vibrotactile stimulation has a first vibrating property and the second vibrotactile stimulation has a second vibrating property different than the first vibrating property. Example vibrating properties include vibrating frequency, vibrating frequency range, wave shape, continuousness, frequency phase, and direction of mechanical force.

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.

Methods and systems of evaluating cardiac pacing in candidate patients for cardiac resynchronization therapy and cardiac resynchronization therapy patients are disclosed. The methods and systems disclosed allow treatments to be personalized to patients by measuring the extent of tissue capture from cardiac pacing under various therapy parameter conditions. Systems and methods of optimizing right ventricle only cardiac pacing are also disclosed.

Disclosed is a method and apparatus for more locally stimulating a desired stimulation region in a predetermined part of an object, the apparatus including a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object, a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object, and a controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle.

The present invention classifies disorders, including Local Anesthetic Responsive Headaches as a general class. The present invention also uses exclusion and inclusion criteria in order to better determine the proper treatment of disorders including dorsonasal targeted therapies.

An endoluminal neurostimulation device includes a plurality of ultrasound transducer elements forming a transducer array. The plurality of transducer elements are provided on or in a substrate layer that is adapted for endoluminal delivery to a deployment site in a lumen of a subject. The transducer elements are operable to focus acoustic energy emitted from the transducer array by controlling one or more of the phase delay and time delay of ultrasound signals emitted from the plurality of transducer elements such that acoustic energy emitted from the transducer array is maximised at a neuronal target near the deployment site to achieve stimulation thereof.

The present disclosure is associated with monitoring health of a patient. An example electromagnetic-evoked acoustic device includes an electromagnetic component to emit energy toward tissue of a patient to cause the energy to be absorbed by the tissue; an ultrasound transmission component to transmit acoustic energy toward the tissue to cause a biological response from the tissue; and an ultrasound sensing component to sense the biological response from the tissue to permit a status of the tissue to be determined, wherein the biological response is sensed based on the energy absorbed by the tissue during the biological response.